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Items: 1 to 20 of 140

1.

Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate.

Skordalakes E, Dodson GG, Green DS, Goodwin CA, Scully MF, Hudson HR, Kakkar VV, Deadman JJ.

J Mol Biol. 2001 Aug 17;311(3):549-55.

PMID:
11493008
2.

The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage.

Friedrich R, Steinmetzer T, Huber R, Stürzebecher J, Bode W.

J Mol Biol. 2002 Mar 1;316(4):869-74.

PMID:
11884127
3.

A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.

Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W.

J Mol Biol. 2001 Apr 13;307(5):1451-86.

PMID:
11292354
4.

Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models.

Bertrand JA, Oleksyszyn J, Kam CM, Boduszek B, Presnell S, Plaskon RR, Suddath FL, Powers JC, Williams LD.

Biochemistry. 1996 Mar 12;35(10):3147-55.

PMID:
8605148
5.

Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.

Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M.

J Mol Biol. 1996 May 24;258(5):851-9. Erratum in: J Mol Biol 1996 Oct 18;263(1):99.

PMID:
8637015
6.

Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.

Weir MP, Bethell SS, Cleasby A, Campbell CJ, Dennis RJ, Dix CJ, Finch H, Jhoti H, Mooney CJ, Patel S, Tang CM, Ward M, Wonacott AJ, Wharton CW.

Biochemistry. 1998 May 12;37(19):6645-57.

PMID:
9578548
7.

Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template.

Jhoti H, Cleasby A, Reid S, Thomas PJ, Weir M, Wonacott A.

Biochemistry. 1999 Jun 22;38(25):7969-77.

PMID:
10387040
8.

The crystal structure of phosphonate-inhibited D-Ala-D-Ala peptidase reveals an analogue of a tetrahedral transition state.

Silvaggi NR, Anderson JW, Brinsmade SR, Pratt RF, Kelly JA.

Biochemistry. 2003 Feb 11;42(5):1199-208.

PMID:
12564922
9.

Crystallographic structure of a peptidyl keto acid inhibitor and human alpha-thrombin.

Håkansson K, Tulinsky A, Abelman MM, Miller TA, Vlasuk GP, Bergum PW, Lim-Wilby MS, Brunck TK.

Bioorg Med Chem. 1995 Aug;3(8):1009-17.

PMID:
7582975
10.

Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution.

Chen Z, Li Y, Mulichak AM, Lewis SD, Shafer JA.

Arch Biochem Biophys. 1995 Sep 10;322(1):198-203.

PMID:
7574675
11.

Crystal structure of gamma-chymotrypsin in complex with 7-hydroxycoumarin.

Ghani U, Ng KK, Atta-ur-Rahman, Choudhary MI, Ullah N, James MN.

J Mol Biol. 2001 Nov 30;314(3):519-25.

PMID:
11846564
12.

Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.

Malikayil JA, Burkhart JP, Schreuder HA, Broersma RJ Jr, Tardif C, Kutcher LW 3rd, Mehdi S, Schatzman GL, Neises B, Peet NP.

Biochemistry. 1997 Feb 4;36(5):1034-40.

PMID:
9033393
13.

Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases.

Topf M, Várnai P, Schofield CJ, Richards WG.

Proteins. 2002 May 15;47(3):357-69.

PMID:
11948789
14.

Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.

Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M.

Proteins. 1993 Nov;17(3):252-65.

PMID:
8272424
15.

Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.

Baum B, Muley L, Heine A, Smolinski M, Hangauer D, Klebe G.

J Mol Biol. 2009 Aug 21;391(3):552-64. doi: 10.1016/j.jmb.2009.06.016. Epub 2009 Jun 9.

PMID:
19520086
16.
17.

Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases.

Katz BA, Luong C.

J Mol Biol. 1999 Sep 24;292(3):669-84.

PMID:
10497030
18.

Structure of the RWJ-51084-bovine pancreatic beta-trypsin complex at 1.8 A.

Recacha R, Carson M, Costanzo MJ, Maryanoff B, DeLucas LJ, Chattopadhyay D.

Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1785-91.

PMID:
10531473
19.

Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.

Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK.

Biochemistry. 1998 Sep 1;37(35):12094-103.

PMID:
9724521
20.

Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.

De Simone G, Menchise V, Omaggio S, Pedone C, Scozzafava A, Supuran CT.

Biochemistry. 2003 Aug 5;42(30):9013-21.

PMID:
12885234
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