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Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation.

Bélanger C, Gravel A, Tomoiu A, Janelle ME, Gosselin J, Tremblay MJ, Flamand L.

J Hum Virol. 2001 Mar-Apr;4(2):62-73.


Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors.

Thome M, Schneider P, Hofmann K, Fickenscher H, Meinl E, Neipel F, Mattmann C, Burns K, Bodmer JL, Schröter M, Scaffidi C, Krammer PH, Peter ME, Tschopp J.

Nature. 1997 Apr 3;386(6624):517-21.


Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex.

Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S.

J Biol Chem. 2001 Jun 8;276(23):20633-40. Epub 2001 Mar 5.


The role of c-FLIP in modulation of CD95-induced apoptosis.

Scaffidi C, Schmitz I, Krammer PH, Peter ME.

J Biol Chem. 1999 Jan 15;274(3):1541-8.


Constitutive NF-kappaB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice.

Chugh P, Matta H, Schamus S, Zachariah S, Kumar A, Richardson JA, Smith AL, Chaudhary PM.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12885-90. Epub 2005 Aug 24.


The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex.

Micheau O, Thome M, Schneider P, Holler N, Tschopp J, Nicholson DW, Briand C, Grütter MG.

J Biol Chem. 2002 Nov 22;277(47):45162-71. Epub 2002 Sep 4.


Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis.

Gómez-Angelats M, Cidlowski JA.

J Biol Chem. 2001 Nov 30;276(48):44944-52. Epub 2001 Oct 1.


Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells.

Stürzl M, Hohenadl C, Zietz C, Castanos-Velez E, Wunderlich A, Ascherl G, Biberfeld P, Monini P, Browning PJ, Ensoli B.

J Natl Cancer Inst. 1999 Oct 20;91(20):1725-33.


Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c-FLIP(short).

Chatterjee D, Schmitz I, Krueger A, Yeung K, Kirchhoff S, Krammer PH, Peter ME, Wyche JH, Pantazis P.

Cancer Res. 2001 Oct 1;61(19):7148-54.


Inhibition of CD95 apoptotic signaling by interferon-gamma in human osteoarthritic chondrocytes is associated with increased expression of FLICE inhibitory protein.

Grassi F, Piacentini A, Cristino S, Toneguzzi S, Facchini A, Lisignoli G.

Arthritis Rheum. 2004 Feb;50(2):498-506.


Regulation of CD95 (Fas/APO-1)-induced apoptosis in human chondrocytes.

Kühn K, Lotz M.

Arthritis Rheum. 2001 Jul;44(7):1644-53.


Fas resistance of leukemic eosinophils is due to activation of NF-kappa B by Fas ligation.

Qin Y, Camoretti-Mercado B, Blokh L, Long CG, Ko FD, Hamann KJ.

J Immunol. 2002 Oct 1;169(7):3536-44.

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