Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 152

1.

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth.

Gao X, Pan D.

Genes Dev. 2001 Jun 1;15(11):1383-92.

PMID:
11390358
[PubMed - indexed for MEDLINE]
Free PMC Article
2.
3.

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.

Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N, Vazquez F, Carpenter CL, Kwiatkowski DJ.

J Clin Invest. 2003 Oct;112(8):1223-33.

PMID:
14561707
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.

Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, Ru B, Pan D.

Nat Cell Biol. 2002 Sep;4(9):699-704.

PMID:
12172555
[PubMed - indexed for MEDLINE]
5.

The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb.

Nobukini T, Thomas G.

Novartis Found Symp. 2004;262:148-54; discussion 154-9, 265-8. Review.

PMID:
15562827
[PubMed - indexed for MEDLINE]
6.

Tsc2 is not a critical target of Akt during normal Drosophila development.

Dong J, Pan D.

Genes Dev. 2004 Oct 15;18(20):2479-84. Epub 2004 Oct 1.

PMID:
15466161
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.

Inoki K, Li Y, Zhu T, Wu J, Guan KL.

Nat Cell Biol. 2002 Sep;4(9):648-57.

PMID:
12172553
[PubMed - indexed for MEDLINE]
8.

Tuberous sclerosis gene products in proliferation control.

Hengstschläger M, Rodman DM, Miloloza A, Hengstschläger-Ottnad E, Rosner M, Kubista M.

Mutat Res. 2001 Jul;488(3):233-9. Review.

PMID:
11397651
[PubMed - indexed for MEDLINE]
9.

14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin.

Shumway SD, Li Y, Xiong Y.

J Biol Chem. 2003 Jan 24;278(4):2089-92. Epub 2002 Dec 4.

PMID:
12468542
[PubMed - indexed for MEDLINE]
Free Article
10.

Akt regulates growth by directly phosphorylating Tsc2.

Potter CJ, Pedraza LG, Xu T.

Nat Cell Biol. 2002 Sep;4(9):658-65.

PMID:
12172554
[PubMed - indexed for MEDLINE]
11.

The tuberous sclerosis complex genes in tumor development.

Mak BC, Yeung RS.

Cancer Invest. 2004;22(4):588-603. Review.

PMID:
15565817
[PubMed - indexed for MEDLINE]
12.

Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.

Chan JA, Zhang H, Roberts PS, Jozwiak S, Wieslawa G, Lewin-Kowalik J, Kotulska K, Kwiatkowski DJ.

J Neuropathol Exp Neurol. 2004 Dec;63(12):1236-42.

PMID:
15624760
[PubMed - indexed for MEDLINE]
13.

TSC1 and TSC2: genes that are mutated in the human genetic disorder tuberous sclerosis.

Sampson JR.

Biochem Soc Trans. 2003 Jun;31(Pt 3):592-6.

PMID:
12773162
[PubMed - indexed for MEDLINE]
14.

Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38.

Rosner M, Hofer K, Kubista M, Hengstschläger M.

Oncogene. 2003 Jul 31;22(31):4786-98.

PMID:
12894220
[PubMed - indexed for MEDLINE]
15.

Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.

Uhlmann EJ, Apicelli AJ, Baldwin RL, Burke SP, Bajenaru ML, Onda H, Kwiatkowski D, Gutmann DH.

Oncogene. 2002 Jun 6;21(25):4050-9.

PMID:
12037687
[PubMed - indexed for MEDLINE]
Free Article
16.

The tuberous sclerosis complex (TSC) pathway and mechanism of size control.

Potter CJ, Pedraza LG, Huang H, Xu T.

Biochem Soc Trans. 2003 Jun;31(Pt 3):584-6. Review.

PMID:
12773160
[PubMed - indexed for MEDLINE]
17.

Growth signaling: TSC takes its place.

Marygold SJ, Leevers SJ.

Curr Biol. 2002 Nov 19;12(22):R785-7. Review.

PMID:
12445406
[PubMed - indexed for MEDLINE]
Free Article
18.

Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis.

Jones AC, Shyamsundar MM, Thomas MW, Maynard J, Idziaszczyk S, Tomkins S, Sampson JR, Cheadle JP.

Am J Hum Genet. 1999 May;64(5):1305-15. Review.

PMID:
10205261
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies.

Shah OJ, Wang Z, Hunter T.

Curr Biol. 2004 Sep 21;14(18):1650-6.

PMID:
15380067
[PubMed - indexed for MEDLINE]
Free Article
20.

Regulation of TSC2 by 14-3-3 binding.

Li Y, Inoki K, Yeung R, Guan KL.

J Biol Chem. 2002 Nov 22;277(47):44593-6. Epub 2002 Oct 2.

PMID:
12364343
[PubMed - indexed for MEDLINE]
Free Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk