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Items: 1 to 20 of 115

1.

Potent and selective nonpeptide inhibitors of caspases 3 and 7.

Lee D, Long SA, Murray JH, Adams JL, Nuttall ME, Nadeau DP, Kikly K, Winkler JD, Sung CM, Ryan MD, Levy MA, Keller PM, DeWolf WE Jr.

J Med Chem. 2001 Jun 7;44(12):2015-26.

PMID:
11384246
2.

Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.

Lee D, Long SA, Adams JL, Chan G, Vaidya KS, Francis TA, Kikly K, Winkler JD, Sung CM, Debouck C, Richardson S, Levy MA, DeWolf WE Jr, Keller PM, Tomaszek T, Head MS, Ryan MD, Haltiwanger RC, Liang PH, Janson CA, McDevitt PJ, Johanson K, Concha NO, Chan W, Abdel-Meguid SS, Badger AM, Lark MW, Nadeau DP, Suva LJ, Gowen M, Nuttall ME.

J Biol Chem. 2000 May 26;275(21):16007-14.

3.

Fluorinated isatin derivatives. Part 3. New side-chain fluoro-functionalized pyrrolidinyl sulfonyl isatins as potent caspase-3 and -7 inhibitors.

Podichetty AK, Wagner S, Faust A, Schäfers M, Schober O, Kopka K, Haufe G.

Future Med Chem. 2009 Aug;1(5):969-89. doi: 10.4155/fmc.09.66.

PMID:
21426092
4.

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.

Chu W, Zhang J, Zeng C, Rothfuss J, Tu Z, Chu Y, Reichert DE, Welch MJ, Mach RH.

J Med Chem. 2005 Dec 1;48(24):7637-47.

PMID:
16302804
5.

5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.

Kopka K, Faust A, Keul P, Wagner S, Breyholz HJ, Höltke C, Schober O, Schäfers M, Levkau B.

J Med Chem. 2006 Nov 16;49(23):6704-15.

PMID:
17154501
6.

Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.

Chu W, Rothfuss J, d'Avignon A, Zeng C, Zhou D, Hotchkiss RS, Mach RH.

J Med Chem. 2007 Jul 26;50(15):3751-5. Epub 2007 Jun 23.

PMID:
17585855
7.

In vitro cytotoxicity evaluation of some substituted isatin derivatives.

Vine KL, Locke JM, Ranson M, Benkendorff K, Pyne SG, Bremner JB.

Bioorg Med Chem. 2007 Jan 15;15(2):931-8. Epub 2006 Oct 20. Erratum in: Bioorg Med Chem. 2007 Jun 1;15(11):3951. Benkendorff, Kirsten [added].

PMID:
17088067
8.

Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.

Chu W, Rothfuss J, Chu Y, Zhou D, Mach RH.

J Med Chem. 2009 Apr 23;52(8):2188-91. doi: 10.1021/jm900135r.

PMID:
19326941
9.

Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes.

Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M.

Mol Cell. 2006 Aug;23(4):509-21.

10.

Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid.

Wang Y, Guan L, Jia S, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1379-83.

PMID:
15713391
11.

Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.

Choong IC, Lew W, Lee D, Pham P, Burdett MT, Lam JW, Wiesmann C, Luong TN, Fahr B, DeLano WL, McDowell RS, Allen DA, Erlanson DA, Gordon EM, O'Brien T.

J Med Chem. 2002 Nov 7;45(23):5005-22.

PMID:
12408711
12.

Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis.

Podichetty AK, Wagner S, Schröer S, Faust A, Schäfers M, Schober O, Kopka K, Haufe G.

J Med Chem. 2009 Jun 11;52(11):3484-95. doi: 10.1021/jm8015014.

PMID:
19445513
13.

A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury.

Chapman JG, Magee WP, Stukenbrok HA, Beckius GE, Milici AJ, Tracey WR.

Eur J Pharmacol. 2002 Dec 5;456(1-3):59-68.

PMID:
12450570
14.

Synthesis and structure-activity relationships of oxamyl dipeptide caspase inhibitors developed for the treatment of liver disease.

Ueno H, Kawai M, Shimokawa H, Hirota M, Ohmi M, Sudo R, Ohta A, Arano Y, Hattori K, Ohmi T, Kato N, Kojima M, Ueno Y, Yamamoto M, Moriguchi Y, Eda H, Masubuchi K.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):199-202. doi: 10.1016/j.bmcl.2008.10.117. Epub 2008 Nov 5.

PMID:
19013793
16.

Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors.

Podichetty AK, Faust A, Kopka K, Wagner S, Schober O, Schäfers M, Haufe G.

Bioorg Med Chem. 2009 Apr 1;17(7):2680-8. doi: 10.1016/j.bmc.2009.02.048. Epub 2009 Mar 1.

PMID:
19299147
17.

Screening for caspase-3 inhibitors: a new class of potent small-molecule inhibitors of caspase-3.

Okun I, Malarchuk S, Dubrovskaya E, Khvat A, Tkachenko S, Kysil V, Ilyin A, Kravchenko D, Prossnitz ER, Sklar L, Ivachtchenko A.

J Biomol Screen. 2006 Apr;11(3):277-85. Epub 2006 Feb 20.

PMID:
16490769
18.

Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria.

Marzo I, Pérez-Galán P, Giraldo P, Rubio-Félix D, Anel A, Naval J.

Biochem J. 2001 Nov 1;359(Pt 3):537-46.

19.

Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery.

Talanian RV, Brady KD, Cryns VL.

J Med Chem. 2000 Sep 7;43(18):3351-71. Review. No abstract available.

PMID:
10978183
20.

Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis.

Zhou D, Chu W, Rothfuss J, Zeng C, Xu J, Jones L, Welch MJ, Mach RH.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5041-6. Epub 2006 Aug 7.

PMID:
16891117
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