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A novel role for STAT3 in cardiac remodeling.

Yamauchi-Takihara K, Kishimoto T.

Trends Cardiovasc Med. 2000 Oct;10(7):298-303. Review.


Gp130-mediated pathway and left ventricular remodeling.

Yamauchi-Takihara K.

J Card Fail. 2002 Dec;8(6 Suppl):S374-8.


gp130-mediated pathway and heart failure.

Yamauchi-Takihara K.

Future Cardiol. 2008 Jul;4(4):427-37. doi: 10.2217/14796678.4.4.427.


Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age.

Jacoby JJ, Kalinowski A, Liu MG, Zhang SS, Gao Q, Chai GX, Ji L, Iwamoto Y, Li E, Schneider M, Russell KS, Fu XY.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12929-34. Epub 2003 Oct 17.


Characterization of the roles of STAT1 and STAT3 signal transduction pathways in mammalian lens development.

Ebong S, Chepelinsky AB, Robinson ML, Zhao H, Yu CR, Egwuagu CE.

Mol Vis. 2004 Feb 19;10:122-31.


Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation.

Ernst M, Inglese M, Waring P, Campbell IK, Bao S, Clay FJ, Alexander WS, Wicks IP, Tarlinton DM, Novak U, Heath JK, Dunn AR.

J Exp Med. 2001 Jul 16;194(2):189-203.


Crosstalk between ERK1/2 and STAT3 in the modulation of cardiomyocyte hypertrophy induced by cardiotrophin-1.

Li YJ, Cui W, Tian ZJ, Hao YM, Du J, Liu F, Zhang H, Zu XG, Liu SY, Xie RQ, Yang XH, Wu YZ, Chen L, An W.

Chin Med J (Engl). 2004 Aug;117(8):1135-42.


Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.

Kunisada K, Negoro S, Tone E, Funamoto M, Osugi T, Yamada S, Okabe M, Kishimoto T, Yamauchi-Takihara K.

Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):315-9.


STAT proteins as novel targets for cancer drug discovery.

Turkson J.

Expert Opin Ther Targets. 2004 Oct;8(5):409-22. Review.


Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

Buettner R, Mora LB, Jove R.

Clin Cancer Res. 2002 Apr;8(4):945-54. Review.


Many good reasons to have STAT3 in the heart.

Hilfiker-Kleiner D, Hilfiker A, Drexler H.

Pharmacol Ther. 2005 Jul;107(1):131-7. Epub 2005 Apr 21. Review.


The Jak-STAT pathway stimulated by interleukin 6.

Horvath CM.

Sci STKE. 2004 Nov 23;2004(260):tr9.


Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines.

Kaur N, Kim IJ, Higgins D, Halvorsen SW.

J Neurochem. 2003 Oct;87(2):437-47.


The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis.

Jenkins BJ, Roberts AW, Najdovska M, Grail D, Ernst M.

Blood. 2005 May 1;105(9):3512-20. Epub 2005 Jan 13.


Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.

Mora LB, Buettner R, Seigne J, Diaz J, Ahmad N, Garcia R, Bowman T, Falcone R, Fairclough R, Cantor A, Muro-Cacho C, Livingston S, Karras J, Pow-Sang J, Jove R.

Cancer Res. 2002 Nov 15;62(22):6659-66.


STAT proteins: novel molecular targets for cancer drug discovery.

Turkson J, Jove R.

Oncogene. 2000 Dec 27;19(56):6613-26. Review.


Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth.

Rivat C, Rodrigues S, Bruyneel E, Piétu G, Robert A, Redeuilh G, Bracke M, Gespach C, Attoub S.

Cancer Res. 2005 Jan 1;65(1):195-202. Erratum in: Cancer Res. 2005 Mar 15;65(6):2505. Christine, Rivat [corrected to Rivat, Christine]; Sylvie, Rodrigues [corrected to Rodrigues, Sylvie]; Erik, Bruyneel [corrected to Bruyneel, Erik]; Geneviéve, Piétu [corrected to Piétu, Geneviéve]; Amélie, Robert [corrected to Robert, Amélie]; Gérard, Redeuilh [corrected to Redeuilh, Gérard]; Marc, Bracke [corrected to Bracke, Marc]; Christian, Gespach [corrected to Gespach, Christian]; Samir, Attoub [corrected to Attoub, Samir].


Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway.

Numata A, Shimoda K, Kamezaki K, Haro T, Kakumitsu H, Shide K, Kato K, Miyamoto T, Yamashita Y, Oshima Y, Nakajima H, Iwama A, Aoki K, Takase K, Gondo H, Mano H, Harada M.

J Biol Chem. 2005 Apr 1;280(13):12621-9. Epub 2005 Jan 21.

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