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Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.

Blanco G, Patallo EP, Braña AF, Trefzer A, Bechthold A, Rohr J, Méndez C, Salas JA.

Chem Biol. 2001 Mar;8(3):253-63.


Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.

Ramos A, Lombó F, Braña AF, Rohr J, Méndez C, Salas JA.

Microbiology. 2008 Mar;154(Pt 3):781-8. doi: 10.1099/mic.0.2007/014035-0.


Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.

Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA.

J Biol Chem. 2001 Jun 1;276(22):18765-74. Epub 2001 Feb 28.


Generation of hybrid elloramycin analogs by combinatorial biosynthesis using genes from anthracycline-type and macrolide biosynthetic pathways.

Rodriguez L, Oelkers C, Aguirrezabalaga I, Braña AF, Rohr J, Méndez C, Salas JA.

J Mol Microbiol Biotechnol. 2000 Jul;2(3):271-6.


Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT.

Fischer C, Rodríguez L, Patallo EP, Lipata F, Braña AF, Méndez C, Salas JA, Rohr J.

J Nat Prod. 2002 Nov;65(11):1685-9.


Identification of Streptomyces olivaceus Tü 2353 genes involved in the production of the polyketide elloramycin.

Decker H, Rohr J, Motamedi H, Zähner H, Hutchinson CR.

Gene. 1995 Dec 1;166(1):121-6.


Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis.

Ramos A, Olano C, Braña AF, Méndez C, Salas JA.

J Bacteriol. 2009 Apr;191(8):2871-5. doi: 10.1128/JB.01747-08. Epub 2009 Feb 20.


Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.

Lombó F, Gibson M, Greenwell L, Braña AF, Rohr J, Salas JA, Méndez C.

Chem Biol. 2004 Dec;11(12):1709-18.


Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds.

Rodríguez L, Aguirrezabalaga I, Allende N, Braña AF, Méndez C, Salas JA.

Chem Biol. 2002 Jun;9(6):721-9.


[Cloning and identification of the priming glycosyltransferase gene involved in exopolysaccharide 139A biosynthesis in Streptomyces].

Wang LY, Li ST, Guo LH, Jiang R, Li Y.

Yi Chuan Xue Bao. 2003 Aug;30(8):723-9. Chinese.


Ketoolivosyl-tetracenomycin C: a new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGT.

Nybo SE, Shabaan KA, Kharel MK, Sutardjo H, Salas JA, Méndez C, Rohr J.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2247-50. doi: 10.1016/j.bmcl.2012.01.094. Epub 2012 Feb 3.


Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.

Blanco G, Fernández E, Fernández MJ, Braña AF, Weissbach U, Künzel E, Rohr J, Méndez C, Salas JA.

Mol Gen Genet. 2000 Jan;262(6):991-1000.


The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.

Hoffmeister D, Ichinose K, Domann S, Faust B, Trefzer A, Dräger G, Kirschning A, Fischer C, Künzel E, Bearden D, Rohr J, Bechthold A.

Chem Biol. 2000 Nov;7(11):821-31.


Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.

Lozano MJ, Remsing LL, Quirós LM, Braña AF, Fernández E, Sánchez C, Méndez C, Rohr J, Salas JA.

J Biol Chem. 2000 Feb 4;275(5):3065-74.


Function of glycosyltransferase genes involved in urdamycin A biosynthesis.

Trefzer A, Hoffmeister D, Künzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A.

Chem Biol. 2000 Feb;7(2):133-42.


Elucidation of the function of two glycosyltransferase genes (lanGT1 and lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide antibiotics.

Trefzer A, Fischer C, Stockert S, Westrich L, Künzel E, Girreser U, Rohr J, Bechthold A.

Chem Biol. 2001 Dec;8(12):1239-52.


Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.

Prado L, Fernández E, Weissbach U, Blanco G, Quirós LM, Braña AF, Méndez C, Rohr J, Salas JA.

Chem Biol. 1999 Jan;6(1):19-30.

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