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Results: 1 to 20 of 342

1.

Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome.

Seebohm G, Scherer CR, Busch AE, Lerche C.

J Biol Chem. 2001 Apr 27;276(17):13600-5. Epub 2001 Jan 17.

PMID:
11278406
[PubMed - indexed for MEDLINE]
Free Article
2.

Molecular determinants of KCNQ1 channel block by a benzodiazepine.

Seebohm G, Chen J, Strutz N, Culberson C, Lerche C, Sanguinetti MC.

Mol Pharmacol. 2003 Jul;64(1):70-7.

PMID:
12815162
[PubMed - indexed for MEDLINE]
Free Article
3.

Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels.

Seebohm G, Westenskow P, Lang F, Sanguinetti MC.

J Physiol. 2005 Mar 1;563(Pt 2):359-68. Epub 2005 Jan 13.

PMID:
15649981
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels.

Seebohm G, Pusch M, Chen J, Sanguinetti MC.

Circ Res. 2003 Nov 14;93(10):941-7. Epub 2003 Oct 23.

PMID:
14576198
[PubMed - indexed for MEDLINE]
Free Article
5.

Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy.

Yang WP, Levesque PC, Little WA, Conder ML, Ramakrishnan P, Neubauer MG, Blanar MA.

J Biol Chem. 1998 Jul 31;273(31):19419-23.

PMID:
9677360
[PubMed - indexed for MEDLINE]
Free Article
6.

Clinical and electrophysiological characterization of a novel mutation (F193L) in the KCNQ1 gene associated with long QT syndrome.

Yamaguchi M, Shimizu M, Ino H, Terai H, Hayashi K, Mabuchi H, Hoshi N, Higashida H.

Clin Sci (Lond). 2003 Apr;104(4):377-82.

PMID:
12653681
[PubMed - indexed for MEDLINE]
Free Article
7.

Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits.

Franqueza L, Lin M, Shen J, Splawski I, Keating MT, Sanguinetti MC.

J Biol Chem. 1999 Jul 23;274(30):21063-70. Erratum in: J Biol Chem 1999 Aug 27;274(35):25188.

PMID:
10409658
[PubMed - indexed for MEDLINE]
Free Article
8.

KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel.

Tinel N, Diochot S, Borsotto M, Lazdunski M, Barhanin J.

EMBO J. 2000 Dec 1;19(23):6326-30.

PMID:
11101505
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.

Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT.

Nature. 1996 Nov 7;384(6604):80-3.

PMID:
8900283
[PubMed - indexed for MEDLINE]
10.

Structural determinants of M-type KCNQ (Kv7) K+ channel assembly.

Schwake M, Athanasiadu D, Beimgraben C, Blanz J, Beck C, Jentsch TJ, Saftig P, Friedrich T.

J Neurosci. 2006 Apr 5;26(14):3757-66.

PMID:
16597729
[PubMed - indexed for MEDLINE]
Free Article
11.

Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome.

Zehelein J, Thomas D, Khalil M, Wimmer AB, Koenen M, Licka M, Wu K, Kiehn J, Brockmeier K, Kreye VA, Karle CA, Katus HA, Ulmer HE, Schoels W.

Biochim Biophys Acta. 2004 Nov 5;1690(3):185-92.

PMID:
15511625
[PubMed - indexed for MEDLINE]
Free Article
12.

Dominant-negative KvLQT1 mutations underlie the LQT1 form of long QT syndrome.

Shalaby FY, Levesque PC, Yang WP, Little WA, Conder ML, Jenkins-West T, Blanar MA.

Circulation. 1997 Sep 16;96(6):1733-6.

PMID:
9323054
[PubMed - indexed for MEDLINE]
Free Article
13.

Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels.

Seebohm G, Sanguinetti MC, Pusch M.

J Physiol. 2003 Oct 15;552(Pt 2):369-78. Erratum in: J Physiol. 2004 May 1;556(Pt 3):1013.

PMID:
14561821
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Regulation of deactivation by an amino terminal domain in human ether-Ă -go-go-related gene potassium channels.

Wang J, Trudeau MC, Zappia AM, Robertson GA.

J Gen Physiol. 1998 Nov;112(5):637-47. Erratum in: J Gen Physiol 1999 Feb;113(2):359.

PMID:
9806971
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

C-terminal interaction of KCNQ2 and KCNQ3 K+ channels.

Maljevic S, Lerche C, Seebohm G, Alekov AK, Busch AE, Lerche H.

J Physiol. 2003 Apr 15;548(Pt 2):353-60. Epub 2003 Mar 14.

PMID:
12640002
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Characterization of an LQT5-related mutation in KCNE1, Y81C: implications for a role of KCNE1 cytoplasmic domain in IKs channel function.

Wu DM, Lai LP, Zhang M, Wang HL, Jiang M, Liu XS, Tseng GN.

Heart Rhythm. 2006 Sep;3(9):1031-40. Epub 2006 May 25.

PMID:
16945797
[PubMed - indexed for MEDLINE]
17.

Biophysical characteristics of a new mutation on the KCNQ1 potassium channel (L251P) causing long QT syndrome.

DeschĂȘnes D, Acharfi S, Pouliot V, Hegele R, Krahn A, Daleau P, Chahine M.

Can J Physiol Pharmacol. 2003 Feb;81(2):129-34.

PMID:
12710526
[PubMed - indexed for MEDLINE]
18.

Location and orientation of minK within the I(Ks) potassium channel complex.

Tapper AR, George AL Jr.

J Biol Chem. 2001 Oct 12;276(41):38249-54. Epub 2001 Jul 30.

PMID:
11479291
[PubMed - indexed for MEDLINE]
Free Article
19.

Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels.

Hadley JK, Noda M, Selyanko AA, Wood IC, Abogadie FC, Brown DA.

Br J Pharmacol. 2000 Feb;129(3):413-5.

PMID:
10711337
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Long QT syndrome-associated mutations in the voltage sensor of I(Ks) channels.

Henrion U, Strutz-Seebohm N, Duszenko M, Lang F, Seebohm G.

Cell Physiol Biochem. 2009;24(1-2):11-6. doi: 10.1159/000227828. Epub 2009 Jul 1.

PMID:
19590188
[PubMed - indexed for MEDLINE]
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