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Results: 1 to 20 of 94

1.

Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments.

Yau JL, Noble J, Kenyon CJ, Hibberd C, Kotelevtsev Y, Mullins JJ, Seckl JR.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4716-21. Epub 2001 Mar 27.

PMID:
11274359
[PubMed - indexed for MEDLINE]
Free PMC Article
2.
3.

Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice.

Morton NM, Holmes MC, Fiévet C, Staels B, Tailleux A, Mullins JJ, Seckl JR.

J Biol Chem. 2001 Nov 2;276(44):41293-300. Epub 2001 Aug 23.

PMID:
11546766
[PubMed - indexed for MEDLINE]
Free Article
4.

11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?

Seckl JR.

Front Neuroendocrinol. 1997 Jan;18(1):49-99. Review.

PMID:
9000459
[PubMed - indexed for MEDLINE]
5.

In vivo characterization of 11beta-hydroxysteroid dehydrogenase in rat hippocampus using glucocorticoid neuroendangerment as an endpoint.

Ajilore OA, Sapolsky RM.

Neuroendocrinology. 1999 Feb;69(2):138-44.

PMID:
9986927
[PubMed - indexed for MEDLINE]
6.

11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.

Kotelevtsev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR, Mullins JJ.

Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14924-9.

PMID:
9405715
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Phenotypic analysis of mice bearing targeted deletions of 11beta-hydroxysteroid dehydrogenases 1 and 2 genes.

Holmes MC, Kotelevtsev Y, Mullins JJ, Seckl JR.

Mol Cell Endocrinol. 2001 Jan 22;171(1-2):15-20. Review.

PMID:
11165006
[PubMed - indexed for MEDLINE]
8.
9.

Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets.

Davani B, Khan A, Hult M, Mårtensson E, Okret S, Efendic S, Jörnvall H, Oppermann UC.

J Biol Chem. 2000 Nov 10;275(45):34841-4.

PMID:
10973946
[PubMed - indexed for MEDLINE]
Free Article
10.

11beta-hydroxysteroid dehydrogenase is a predominant reductase in intact rat Leydig cells.

Leckie CM, Welberg LA, Seckl JR.

J Endocrinol. 1998 Nov;159(2):233-8.

PMID:
9795363
[PubMed - indexed for MEDLINE]
Free Article
11.
12.

Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action.

Seckl JR, Walker BR.

Endocrinology. 2001 Apr;142(4):1371-6. Review.

PMID:
11250914
[PubMed - indexed for MEDLINE]
13.

The role of 11beta-hydroxysteroid dehydrogenases in the brain.

Holmes MC, Seckl JR.

Mol Cell Endocrinol. 2006 Mar 27;248(1-2):9-14. Epub 2006 Jan 18. Review.

PMID:
16413106
[PubMed - indexed for MEDLINE]
15.

Tissue- and temporal-specific regulation of 11beta-hydroxysteroid dehydrogenase type 1 by glucocorticoids in vivo.

Jamieson PM, Chapman KE, Seckl JR.

J Steroid Biochem Mol Biol. 1999 Mar;68(5-6):245-50.

PMID:
10416840
[PubMed - indexed for MEDLINE]
16.

11beta-hydroxysteroid dehydrogenase type 1 deficiency prevents memory deficits with aging by switching from glucocorticoid receptor to mineralocorticoid receptor-mediated cognitive control.

Yau JL, Noble J, Seckl JR.

J Neurosci. 2011 Mar 16;31(11):4188-93. doi: 10.1523/JNEUROSCI.6145-10.2011.

PMID:
21411659
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated.

Napolitano A, Voice MW, Edwards CR, Seckl JR, Chapman KE.

J Steroid Biochem Mol Biol. 1998 Mar;64(5-6):251-60.

PMID:
9618026
[PubMed - indexed for MEDLINE]
18.

Foetal lung maturation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice.

Hundertmark S, Dill A, Ebert A, Zimmermann B, Kotelevtsev YV, Mullins JJ, Seckl JR.

Horm Metab Res. 2002 Oct;34(10):545-9.

PMID:
12439781
[PubMed - indexed for MEDLINE]
19.

Enhanced hippocampal long-term potentiation and spatial learning in aged 11beta-hydroxysteroid dehydrogenase type 1 knock-out mice.

Yau JL, McNair KM, Noble J, Brownstein D, Hibberd C, Morton N, Mullins JJ, Morris RG, Cobb S, Seckl JR.

J Neurosci. 2007 Sep 26;27(39):10487-96.

PMID:
17898220
[PubMed - indexed for MEDLINE]
Free Article
20.

Distribution of glucocorticoid and mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenases in human and rat ocular tissues.

Stokes J, Noble J, Brett L, Phillips C, Seckl JR, O'Brien C, Andrew R.

Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1629-38.

PMID:
10845579
[PubMed - indexed for MEDLINE]
Free Article

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