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Results: 1 to 20 of 147

1.

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.

Benjannet S, Elagoz A, Wickham L, Mamarbachi M, Munzer JS, Basak A, Lazure C, Cromlish JA, Sisodia S, Checler F, Chr├ętien M, Seidah NG.

J Biol Chem. 2001 Apr 6;276(14):10879-87. Epub 2001 Jan 10.

PMID:
11152688
[PubMed - indexed for MEDLINE]
Free Article
2.

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Wu GX, Chen-Dodson E, Price E, Li Y, Xu M, Huang Q, Sardana MK, Hazuda DJ.

J Biol Chem. 2003 Jun 6;278(23):21286-94. Epub 2003 Mar 27.

PMID:
12665519
[PubMed - indexed for MEDLINE]
Free Article
3.

A non-amyloidogenic function of BACE-2 in the secretory pathway.

Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J.

J Neurochem. 2002 Jun;81(5):1011-20.

PMID:
12065613
[PubMed - indexed for MEDLINE]
4.

Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.

Pitsi D, Kienlen-Campard P, Octave JN.

J Neurochem. 2002 Oct;83(2):390-9.

PMID:
12423249
[PubMed - indexed for MEDLINE]
5.

Apical sorting of beta-secretase limits amyloid beta-peptide production.

Capell A, Meyn L, Fluhrer R, Teplow DB, Walter J, Haass C.

J Biol Chem. 2002 Feb 15;277(7):5637-43. Epub 2001 Dec 6.

PMID:
11741885
[PubMed - indexed for MEDLINE]
Free Article
6.

The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.

Benjannet S, Cromlish JA, Diallo K, Chr├ętien M, Seidah NG.

Biochem Biophys Res Commun. 2004 Dec 3;325(1):235-42.

PMID:
15522224
[PubMed - indexed for MEDLINE]
7.

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

Spoelgen R, von Arnim CA, Thomas AV, Peltan ID, Koker M, Deng A, Irizarry MC, Andersen OM, Willnow TE, Hyman BT.

J Neurosci. 2006 Jan 11;26(2):418-28.

PMID:
16407538
[PubMed - indexed for MEDLINE]
Free Article
8.

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase.

Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, Louis JC, Citron M, Vassar R.

J Biol Chem. 2000 Dec 1;275(48):37712-7. Erratum in: J Biol Chem 2001 May 4;276(18):15561.

PMID:
10956649
[PubMed - indexed for MEDLINE]
Free Article
9.

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties.

Haniu M, Denis P, Young Y, Mendiaz EA, Fuller J, Hui JO, Bennett BD, Kahn S, Ross S, Burgess T, Katta V, Rogers G, Vassar R, Citron M.

J Biol Chem. 2000 Jul 14;275(28):21099-106.

PMID:
10887202
[PubMed - indexed for MEDLINE]
Free Article
10.

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.

Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L.

Hum Mol Genet. 2001 Jun 1;10(12):1317-24.

PMID:
11406613
[PubMed - indexed for MEDLINE]
Free Article
11.

Processing of beta-secretase by furin and other members of the proprotein convertase family.

Creemers JW, Ines Dominguez D, Plets E, Serneels L, Taylor NA, Multhaup G, Craessaerts K, Annaert W, De Strooper B.

J Biol Chem. 2001 Feb 9;276(6):4211-7. Epub 2000 Nov 8.

PMID:
11071887
[PubMed - indexed for MEDLINE]
Free Article
12.

Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.

Gandhi S, Refolo LM, Sambamurti K.

J Mol Neurosci. 2004;24(1):137-43.

PMID:
15314262
[PubMed - indexed for MEDLINE]
13.

The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity.

Fischer F, Molinari M, Bodendorf U, Paganetti P.

J Neurochem. 2002 Mar;80(6):1079-88.

PMID:
11953458
[PubMed - indexed for MEDLINE]
14.

Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles.

Hook VY, Toneff T, Aaron W, Yasothornsrikul S, Bundey R, Reisine T.

J Neurochem. 2002 Apr;81(2):237-56.

PMID:
12064471
[PubMed - indexed for MEDLINE]
16.

The beta-secretase, BACE: a prime drug target for Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2001 Oct;17(2):157-70. Review.

PMID:
11816789
[PubMed - indexed for MEDLINE]
17.

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

Bodendorf U, Danner S, Fischer F, Stefani M, Sturchler-Pierrat C, Wiederhold KH, Staufenbiel M, Paganetti P.

J Neurochem. 2002 Mar;80(5):799-806.

PMID:
11948243
[PubMed - indexed for MEDLINE]
18.

Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.

Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.

J Neurosci Res. 2003 Nov 1;74(3):386-92.

PMID:
14598315
[PubMed - indexed for MEDLINE]
19.

Recombinant insect cell expression and purification of human beta-secretase (BACE-1) for X-ray crystallography.

Bruinzeel W, Yon J, Giovannelli S, Masure S.

Protein Expr Purif. 2002 Oct;26(1):139-48.

PMID:
12356481
[PubMed - indexed for MEDLINE]

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