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Items: 1 to 20 of 94


Molecular impact of MinK on the enantiospecific block of I(Ks) by chromanols.

Lerche C, Seebohm G, Wagner CI, Scherer CR, Dehmelt L, Abitbol I, Gerlach U, Brendel J, Attali B, Busch AE.

Br J Pharmacol. 2000 Dec;131(8):1503-6.


A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B.

Seebohm G, Lerche C, Pusch M, Steinmeyer K, Br├╝ggemann A, Busch AE.

Br J Pharmacol. 2001 Dec;134(8):1647-54.


Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels.

Yang IC, Scherz MW, Bahinski A, Bennett PB, Murray KT.

J Pharmacol Exp Ther. 2000 Sep;294(3):955-62.


Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel.

Bett GC, Morales MJ, Beahm DL, Duffey ME, Rasmusson RL.

J Physiol. 2006 Nov 1;576(Pt 3):755-67. Epub 2006 Aug 3.


Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991.

Wang HS, Brown BS, McKinnon D, Cohen IS.

Mol Pharmacol. 2000 Jun;57(6):1218-23.


Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter.

Lerche C, Bruhova I, Lerche H, Steinmeyer K, Wei AD, Strutz-Seebohm N, Lang F, Busch AE, Zhorov BS, Seebohm G.

Mol Pharmacol. 2007 Jun;71(6):1503-11. Epub 2007 Mar 8. Erratum in: Mol Pharmacol. 2007 Sep;72(3):796.


Modulation of homomeric and heteromeric KCNQ1 channels by external acidification.

Peretz A, Schottelndreier H, Aharon-Shamgar LB, Attali B.

J Physiol. 2002 Dec 15;545(Pt 3):751-66.


Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome.

Seebohm G, Scherer CR, Busch AE, Lerche C.

J Biol Chem. 2001 Apr 27;276(17):13600-5. Epub 2001 Jan 17.


Dependence of I(Ks) biophysical properties on the expression system.

Seebohm G, Lerche C, Busch AE, Bachmann A.

Pflugers Arch. 2001 Sep;442(6):891-5.


The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes.

Panaghie G, Abbott GW.

J Gen Physiol. 2007 Feb;129(2):121-33. Epub 2007 Jan 16.


Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.

Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT.

Nature. 1996 Nov 7;384(6604):80-3.


Subunit composition of minK potassium channels.

Wang KW, Goldstein SA.

Neuron. 1995 Jun;14(6):1303-9.


KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel.

Tinel N, Diochot S, Borsotto M, Lazdunski M, Barhanin J.

EMBO J. 2000 Dec 1;19(23):6326-30.


MinK subdomains that mediate modulation of and association with KvLQT1.

Tapper AR, George AL Jr.

J Gen Physiol. 2000 Sep;116(3):379-90.


Location and orientation of minK within the I(Ks) potassium channel complex.

Tapper AR, George AL Jr.

J Biol Chem. 2001 Oct 12;276(41):38249-54. Epub 2001 Jul 30.


Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex.

Chen H, Kim LA, Rajan S, Xu S, Goldstein SA.

Neuron. 2003 Sep 25;40(1):15-23.

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