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Results: 1 to 20 of 92

1.

A common enzyme connects notch signaling and Alzheimer's disease.

Kopan R, Goate A.

Genes Dev. 2000 Nov 15;14(22):2799-806. Review. No abstract available.

PMID:
11090127
[PubMed - indexed for MEDLINE]
Free Article
2.

Implication of APP secretases in notch signaling.

Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B.

J Mol Neurosci. 2001 Oct;17(2):171-81. Review.

PMID:
11816790
[PubMed - indexed for MEDLINE]
3.

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.

Selkoe DJ.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11039-41. Review.

PMID:
11572965
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Gamma-secretase--intramembrane protease with a complex.

Wolfe MS.

Sci Aging Knowledge Environ. 2003 Mar 19;2003(11):PE7.

PMID:
12844518
[PubMed - indexed for MEDLINE]
5.

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization.

Kopan R, Goate A.

Neuron. 2002 Jan 31;33(3):321-4. Review.

PMID:
11832221
[PubMed - indexed for MEDLINE]
Free Article
6.
7.

Presenilin and gamma-secretase: structure meets function.

Wolfe MS.

J Neurochem. 2001 Mar;76(6):1615-20. Review. No abstract available.

PMID:
11259478
[PubMed - indexed for MEDLINE]
8.

Notch receptor cleavage depends on but is not directly executed by presenilins.

Taniguchi Y, Karlström H, Lundkvist J, Mizutani T, Otaka A, Vestling M, Bernstein A, Donoviel D, Lendahl U, Honjo T.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4014-9. Epub 2002 Mar 12.

PMID:
11891288
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Presenilin proteins and their function during embryonic development and Alzheimer's disease.

Haass C.

Ernst Schering Res Found Workshop. 2000;(29):57-64. Review. No abstract available.

PMID:
10943304
[PubMed - indexed for MEDLINE]
10.

The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease.

Tomita T, Iwatsubo T.

Drug News Perspect. 2004 Jun;17(5):321-5. Review.

PMID:
15334182
[PubMed - indexed for MEDLINE]
11.

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.

Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R, Weng AP, Kutok JL, Aster JC, Kitajewski J.

J Biol Chem. 2004 Jul 16;279(29):30771-80. Epub 2004 May 3.

PMID:
15123653
[PubMed - indexed for MEDLINE]
Free Article
12.

APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.

Wolfe MS.

Int Immunopharmacol. 2002 Dec;2(13-14):1919-29. Review.

PMID:
12489805
[PubMed - indexed for MEDLINE]
13.

Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage.

Sernee MF, Evin G, Culvenor JG, Villadangos JA, Beyreuther K, Masters CL, Cappai R.

Eur J Biochem. 2003 Feb;270(3):495-506.

PMID:
12542699
[PubMed - indexed for MEDLINE]
Free Article
14.

Presenilin-dependent gamma-secretase activity modulates neurite outgrowth.

Figueroa DJ, Morris JA, Ma L, Kandpal G, Chen E, Li YM, Austin CP.

Neurobiol Dis. 2002 Feb;9(1):49-60.

PMID:
11848684
[PubMed - indexed for MEDLINE]
15.

Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

Martys-Zage JL, Kim SH, Berechid B, Bingham SJ, Chu S, Sklar J, Nye J, Sisodia SS.

J Mol Neurosci. 2000 Dec;15(3):189-204.

PMID:
11303783
[PubMed - indexed for MEDLINE]
16.

A portrait of Alzheimer secretases--new features and familiar faces.

Esler WP, Wolfe MS.

Science. 2001 Aug 24;293(5534):1449-54. Review.

PMID:
11520976
[PubMed - indexed for MEDLINE]
17.

Notch signal transduction: a real rip and more.

Weinmaster G.

Curr Opin Genet Dev. 2000 Aug;10(4):363-9. Review.

PMID:
10889061
[PubMed - indexed for MEDLINE]
18.

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.

Tournoy J, Bossuyt X, Snellinx A, Regent M, Garmyn M, Serneels L, Saftig P, Craessaerts K, De Strooper B, Hartmann D.

Hum Mol Genet. 2004 Jul 1;13(13):1321-31. Epub 2004 May 5.

PMID:
15128703
[PubMed - indexed for MEDLINE]
Free Article
19.

Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration.

Selkoe DJ.

Curr Opin Neurobiol. 2000 Feb;10(1):50-7. Review.

PMID:
10679435
[PubMed - indexed for MEDLINE]
20.

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.

Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D.

Dev Cell. 2002 Jul;3(1):85-97.

PMID:
12110170
[PubMed - indexed for MEDLINE]
Free Article

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