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11062067,9889102,9218798,11418587,9639556,10715136,9305750,20156194,9891090,11390361,12624093,9384583,10347227,9890951,11078444,10874022,11560992,12788955,11314034,9661668,10523642,9535930,15328343,7839144,22154358,10713072,15302099,11139391,10862766,11500363,10051439,9029150,15271995,9207092,19135136,10922016,15247271,19289169,11043575,16533805,10727406,9305639,9162092,9890973,11228165,17577251,11959862,10506143,11700022,14712227,11274363,11557063,24257757,15158451,12677442,18713996,12138158,11027220,8871635,16442502,10445851,10527909,7535770,11718727,14616089,12782417,9731215,15380027,12628002,17693927,18182317,12637505,9414114,22130668,9516438,15743762,28082061,19196711,11279118,12220515,14741046,10627526,12021326,10187804,10938283,12171600,11723054,20709173,9096336,12223493,12186863,17157936,11943212,12040039,10207617,24292834,9653550,34502275,22353730,27711255,12354774,9488659,23960075,9108383,11714698,10936203,9584193,11495898,10611240,15850461,11726277,12709432,11978790,10491174,11856743,15107616,7969172,10490613,11849756,9405446,9815259,11839824,9312105,12650921,11959861,10660600,12456688,10891478,14575811,28661486,12384504,11739664,10518804,16195223,15465770,10880959,10785355,10964950,11313405,9372971,20836852,12812981,27297883,18669639,20633641,10477112,22206897,36650421,8967341,11278395,17726008,11597778,11106658,11335711,10913135,8137421,11208906,9824284,10567572,23995397,12694537,22916726,11874576,22730327,14704147,12417588,11435136,12676357,12351623,10759527,20550965,14699111,26364603,21660049,11090222,12427756,12058028,15105425,27618482,24759688,11163770,11595338,15568999,31390677,34502507,10713157,34502457,10820166,19301097,15504961,11069918,11764091,9624152,10620503,12067830,12189133,11602589,17337011,11331425,11278789,9199504,15816852,30367030,10490659,16103752,18720373,20438834,26546672,22090513,11551972,17875933,12039958,25737158,11356842,29248607,11961130,9020184,11076965,30404891,14705642,11551821,31481213,11053415,36826833,21749326,7514173,8621675,11369511,8663524,16794604,9084448,11506194,14699504,14970211,14707132,10383391,12244047,12401814,33175451,10806407,11208531,19888449,14592977,29272037,14741745,14680475,29238080,16043490,15208323,11323415,12221076,20231852,8702571,28779160,26028649,11602244,26443849,23963453,30963560,11257496,12775720,9739089,11566103,12756254,22260670,12052834,12637550,15911620,25172143,23536762,11790785,11104681,9195981,29636017,10187773,30591558,12859971,12821650,12514174,12623839,11781274,19783847,26957005,11788583,22496975,30768270,10825181,23922727,11836244,10506183,22711536,22267733,18948261,15582552,11781324,21372320,15292225,21278800,10508788,1540189,17637567,36340039,37108658,22493283,23226105,8137910,9422734,10514426,16336213,18408005,18375956,31318149,10562607,15284239,26867034,9006942,10536148,14966141,25100604,19366211,1907971,17681939,11557281,14742423,1628739,18555663,15987843,22441692,10403367,27263470,10634915,26868142,12086621,11121010,20404936,17056565,36626580,24302736,17055984,12223490,15033701,33475090,10930532,16984892,12758252,12791252,12829704,11396003,16156785,25646663,12077556,1499729,12506122,34032269,10675481,22031940,16321978,12624102,21148294,31794883,11384840,19286608,10638667,10484329,11439243,23028407,12897450,23073384,7768904,22351776,21438496,22203681,30211540,12646240,9449997,20798394,35200035,15252021,9705322,11305107,26377800,24657496,11259409,12901952,19324872,15755732,8035827,11694646,26728490,1651323,7971947,23981301,11024282,18245086,10940602,34194338,17965192,11856337,25755284,29037961,19054758,10578048,21324895,7750576,30449673,16110156,23060952,15304963,16216881,21123173,12542636,31905931,14521931,29666261,18270588,20630875,12380688,8529658,12507505,18572308,30333228,22496813,28784722,24651600,12913163,35456931,11700305,18381422,12761204,19095804,30837053,11896401,11112081,21384452,31083997,34894681,31579105,12954329,22284361,36651171,18508628,35303787,17957138,32059638,15458637,10854223,21044959,10727080,31708743,20647589,15637069,36649216,21540183,21036249,18337456,31021099,12861985,26962298,8393445,24115095,18469002,35347634,28428613,17001450,21856198,20027304,12933347,29276520,20093040,32630525,31578253,35149678,19361221,34909124,34950110,19861690,23991633,32072069,32337704,32783966,35743047,30210579,10606768,25696767,34575106,19255643,34439869,15729360,36858740,18759402,36764123,33101607,30393206,29126898,25204838,21357059,28220425,32916088,29572137,32359796,33098150,15514308,21317887,21738332,31964936,19644735,14579849,34841853,24267725,30658111,25153342,19390061,35600964,31150223,12372539,22454693,23566306,18460189,36225314,34543009,14726206,29163450,32809819,23875474,20161828,27711350,25667587,35694452,11305109,31524273,35868124,33396582,35979232,34213207,32850305,25031889,23790484,24746561,12873527,11749383,35273590,29338051,30683846,28292786,29622027,37059914[uid]

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Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.

Fleming Y, Armstrong CG, Morrice N, Paterson A, Goedert M, Cohen P. Fleming Y, et al. Biochem J. 2000 Nov 15;352 Pt 1(Pt 1):145-54. Biochem J. 2000. PMID: 11062067 Free PMC article.

Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro.

Lawler S, Fleming Y, Goedert M, Cohen P. Lawler S, et al. Curr Biol. 1998 Dec 17-31;8(25):1387-90. doi: 10.1016/s0960-9822(98)00019-0. Curr Biol. 1998. PMID: 9889102 Free article.

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.

Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P. Goedert M, et al. EMBO J. 1997 Jun 16;16(12):3563-71. doi: 10.1093/emboj/16.12.3563. EMBO J. 1997. PMID: 9218798 Free PMC article.

Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation.

Wada T, Nakagawa K, Watanabe T, Nishitai G, Seo J, Kishimoto H, Kitagawa D, Sasaki T, Penninger JM, Nishina H, Katada T. Wada T, et al. J Biol Chem. 2001 Aug 17;276(33):30892-7. doi: 10.1074/jbc.M011780200. Epub 2001 Jun 19. J Biol Chem. 2001. PMID: 11418587 Free article.

Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1.

Cuenda A, Dorow DS. Cuenda A, et al. Biochem J. 1998 Jul 1;333 ( Pt 1)(Pt 1):11-5. doi: 10.1042/bj3330011. Biochem J. 1998. PMID: 9639556 Free PMC article.

Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.

Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, LoGrasso P. Lisnock J, et al. Biochemistry. 2000 Mar 21;39(11):3141-8. doi: 10.1021/bi992410+. Biochemistry. 2000. PMID: 10715136

SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK).

Lawler S, Cuenda A, Goedert M, Cohen P. Lawler S, et al. FEBS Lett. 1997 Sep 1;414(1):153-8. doi: 10.1016/s0014-5793(97)00990-3. FEBS Lett. 1997. PMID: 9305750 Free article.

Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation.

Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, Nishina H. Nakagawa K, et al. Biochem J. 2010 Mar 29;427(2):237-45. doi: 10.1042/BJ20091011. Biochem J. 2010. PMID: 20156194

The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases.

Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ. Tournier C, et al. Mol Cell Biol. 1999 Feb;19(2):1569-81. doi: 10.1128/MCB.19.2.1569. Mol Cell Biol. 1999. PMID: 9891090 Free PMC article.

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines.

Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. Tournier C, et al. Genes Dev. 2001 Jun 1;15(11):1419-26. doi: 10.1101/gad.888501. Genes Dev. 2001. PMID: 11390361 Free PMC article.

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