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Results: 1 to 20 of 161

1.

Design and synthesis of potential inhibitors of the ergosterol biosynthesis as antifungal agents.

Chung SK, Lee KW, Kang HI, Yamashita C, Kudo M, Yoshida Y.

Bioorg Med Chem. 2000 Oct;8(10):2475-86.

PMID:
11058043
[PubMed - indexed for MEDLINE]
2.

Triazole antifungals. IV. Synthesis and antifungal activities of 3-acylamino-2-aryl-2-butanol derivatives.

Konosu T, Tajima Y, Takeda N, Miyaoka T, Kasahara M, Yasuda H, Oida S.

Chem Pharm Bull (Tokyo). 1991 Oct;39(10):2581-9.

PMID:
1806277
[PubMed - indexed for MEDLINE]
3.

Strong antifungal activity of SS750, a new triazole derivative, is based on its selective binding affinity to cytochrome P450 of fungi.

Matsumoto M, Ishida K, Konagai A, Maebashi K, Asaoka T.

Antimicrob Agents Chemother. 2002 Feb;46(2):308-14.

PMID:
11796335
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives.

Rezaei Z, Khabnadideh S, Pakshir K, Hossaini Z, Amiri F, Assadpour E.

Eur J Med Chem. 2009 Jul;44(7):3064-7. doi: 10.1016/j.ejmech.2008.07.012. Epub 2008 Jul 19.

PMID:
18760508
[PubMed - indexed for MEDLINE]
5.

Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis.

Renard D, Perruchon J, Giera M, Müller J, Bracher F.

Bioorg Med Chem. 2009 Dec 1;17(23):8123-37. doi: 10.1016/j.bmc.2009.09.037. Epub 2009 Sep 25.

PMID:
19833521
[PubMed - indexed for MEDLINE]
6.

The antifungal activity of 2,2'-diamino-4,4'-dithiazole derivatives is due to the possible inhibition of lanosterol-14-alpha-demethylase.

Scozzafava A, Nicolae A, Maior O, Briganti F, Supuran CT.

J Enzyme Inhib. 1998;14(1):49-68.

PMID:
10520759
[PubMed - indexed for MEDLINE]
7.

Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14alpha-demethylase (CYP51) of fungi.

Zhu J, Lu J, Zhou Y, Li Y, Cheng J, Zheng C.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5285-9. Epub 2006 Aug 14.

PMID:
16905318
[PubMed - indexed for MEDLINE]
8.

Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51).

Sun QY, Xu JM, Cao YB, Zhang WN, Wu QY, Zhang DZ, Zhang J, Zhao HQ, Jiang YY.

Eur J Med Chem. 2007 Sep;42(9):1226-33. Epub 2007 Jan 24.

PMID:
17335940
[PubMed - indexed for MEDLINE]
9.

Design, synthesis, and antifungal activities of novel 1H-triazole derivatives based on the structure of the active site of fungal lanosterol 14 alpha-demethylase (CYP51).

Zhao QJ, Hu HG, Li YW, Song Y, Cai LZ, Wu QY, Jiang YY.

Chem Biodivers. 2007 Jul;4(7):1472-9.

PMID:
17638327
[PubMed - indexed for MEDLINE]
10.

Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays.

Venkateswarlu K, Denning DW, Manning NJ, Kelly SL.

Antimicrob Agents Chemother. 1996 Jun;40(6):1382-6.

PMID:
8726005
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis.

Vanden Bossche H, Ausma J, Bohets H, Vermuyten K, Willemsens G, Marichal P, Meerpoel L, Odds F, Borgers M.

Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.

PMID:
15328084
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The antifungal activity of sulfonylated/carboxylated derivatives of dibenzo-1,4-dioxine-2-acetyloxime may be due to inhibition of lanosterol-14alpha-demethylase.

Mastrolorenzo A, Scozzafava A, Supuran CT.

J Enzyme Inhib. 2000;15(6):557-69.

PMID:
11140611
[PubMed - indexed for MEDLINE]
13.

Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives.

Wang W, Sheng C, Che X, Ji H, Miao Z, Yao J, Zhang WN.

Arch Pharm (Weinheim). 2009 Dec;342(12):732-9. doi: 10.1002/ardp.200900103.

PMID:
19899102
[PubMed - indexed for MEDLINE]
14.

Disruption of ergosterol biosynthesis, growth, and the morphological transition in Candida albicans by sterol methyltransferase inhibitors containing sulfur at C-25 in the sterol side chain.

Kanagasabai R, Zhou W, Liu J, Nguyen TT, Veeramachaneni P, Nes WD.

Lipids. 2004 Aug;39(8):737-46.

PMID:
15638241
[PubMed - indexed for MEDLINE]
15.

Design, synthesis and antifungal activity of some new imidazole and triazole derivatives.

Rezaei Z, Khabnadideh S, Zomorodian K, Pakshir K, Kashi G, Sanagoei N, Gholami S.

Arch Pharm (Weinheim). 2011 Oct;344(10):658-65. doi: 10.1002/ardp.201000357. Epub 2011 Aug 25.

PMID:
21984016
[PubMed - indexed for MEDLINE]
16.

[Synthesis and antifungal activity of novel triazole antifungal agents].

Sheng CQ, Zhu J, Zhang WN, Song YL, Zhang M, Ji HT, Yu JX, Yao JZ, Yang S, Miao ZY.

Yao Xue Xue Bao. 2004 Dec;39(12):984-9. Chinese.

PMID:
15813026
[PubMed - indexed for MEDLINE]
17.

Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase.

Chai X, Zhang J, Hu H, Yu S, Sun Q, Dan Z, Jiang Y, Wu Q.

Eur J Med Chem. 2009 May;44(5):1913-20. doi: 10.1016/j.ejmech.2008.11.007. Epub 2008 Nov 24.

PMID:
19097674
[PubMed - indexed for MEDLINE]
18.

Novel antifungal agents which inhibit lanosterol 14alpha-demethylase in Candida albicans CCH442.

Zakula D, Capobianco JO, Goldman RC.

J Antimicrob Chemother. 1997 Feb;39(2):261-4. Erratum in: J Antimicrob Chemother 1998 Jun;41(6):671.

PMID:
9069550
[PubMed - indexed for MEDLINE]
Free Article
19.

Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.

Munayyer HK, Mann PA, Chau AS, Yarosh-Tomaine T, Greene JR, Hare RS, Heimark L, Palermo RE, Loebenberg D, McNicholas PM.

Antimicrob Agents Chemother. 2004 Oct;48(10):3690-6.

PMID:
15388421
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Synthesis of 6(alpha, beta)-aminocholestanols as ergosterol biosynthesis inhibitors.

Beuchet P, el Kihel L, Dherbomez M, Charles G, Letourneux Y.

Bioorg Med Chem Lett. 1998 Dec 15;8(24):3627-30.

PMID:
9934483
[PubMed - indexed for MEDLINE]

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