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Results: 1 to 20 of 148

Similar articles for PubMed (Select 10997902)

1.

A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.

Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ.

Structure. 2000 Aug 15;8(8):831-40.

PMID:
10997902
2.

The crystal structure of cruzain: a therapeutic target for Chagas' disease.

McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ.

J Mol Biol. 1995 Mar 24;247(2):251-9.

PMID:
7707373
3.

Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.

Choe Y, Brinen LS, Price MS, Engel JC, Lange M, Grisostomi C, Weston SG, Pallai PV, Cheng H, Hardy LW, Hartsough DS, McMakin M, Tilton RF, Baldino CM, Craik CS.

Bioorg Med Chem. 2005 Mar 15;13(6):2141-56.

PMID:
15727867
4.

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR.

PLoS Negl Trop Dis. 2010 Sep 14;4(9). pii: e825. doi: 10.1371/journal.pntd.0000825.

5.

Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors.

Scheidt KA, Roush WR, McKerrow JH, Selzer PM, Hansell E, Rosenthal PJ.

Bioorg Med Chem. 1998 Dec;6(12):2477-94.

PMID:
9925304
6.

Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease.

Ljunggren A, Redzynia I, Alvarez-Fernandez M, Abrahamson M, Mort JS, Krupa JC, Jaskolski M, Bujacz G.

J Mol Biol. 2007 Aug 3;371(1):137-53. Epub 2007 May 10.

PMID:
17561110
7.

Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi.

Engel JC, Torres C, Hsieh I, Doyle PS, McKerrow JH.

J Cell Sci. 2000 Apr;113 ( Pt 8):1345-54. Erratum in: J Cell Sci 2000 Jul;113(Pt 14):2638. Garcia CT [corrected to Torres C].

8.

Structural determinants of specificity in the cysteine protease cruzain.

Gillmor SA, Craik CS, Fletterick RJ.

Protein Sci. 1997 Aug;6(8):1603-11.

9.

Aryl ureas represent a new class of anti-trypanosomal agents.

Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH.

Chem Biol. 2000 Sep;7(9):733-42.

10.

Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain.

Huang L, Brinen LS, Ellman JA.

Bioorg Med Chem. 2003 Jan 2;11(1):21-9.

PMID:
12467703
11.

The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease.

Jose Cazzulo J, Stoka V, Turk V.

Curr Pharm Des. 2001 Aug;7(12):1143-56. Review.

PMID:
11472258
12.

Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases.

Redzynia I, Ljunggren A, Bujacz A, Abrahamson M, Jaskolski M, Bujacz G.

FEBS J. 2009 Feb;276(3):793-806. doi: 10.1111/j.1742-4658.2008.06824.x.

PMID:
19143838
13.

Cruzain : the path from target validation to the clinic.

Sajid M, Robertson SA, Brinen LS, McKerrow JH.

Adv Exp Med Biol. 2011;712:100-15. doi: 10.1007/978-1-4419-8414-2_7. Review.

PMID:
21660661
14.

Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.

Lima AP, dos Reis FC, Serveau C, Lalmanach G, Juliano L, Ménard R, Vernet T, Thomas DY, Storer AC, Scharfstein J.

Mol Biochem Parasitol. 2001 Apr 25;114(1):41-52.

PMID:
11356512
15.

Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi.

Engel JC, Doyle PS, Palmer J, Hsieh I, Bainton DF, McKerrow JH.

J Cell Sci. 1998 Mar;111 ( Pt 5):597-606.

16.

Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi.

Monteiro AC, Abrahamson M, Lima AP, Vannier-Santos MA, Scharfstein J.

J Cell Sci. 2001 Nov;114(Pt 21):3933-42.

17.

Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi.

Figueiredo da Silva AA, de Carvalho Vieira L, Krieger MA, Goldenberg S, Zanchin NI, Guimarães BG.

J Struct Biol. 2007 Feb;157(2):416-23. Epub 2006 Aug 17.

PMID:
17011790
18.

Subsite specificity of trypanosomal cathepsin L-like cysteine proteases. Probing the S2 pocket with phenylalanine-derived amino acids.

Lecaille F, Authié E, Moreau T, Serveau C, Gauthier F, Lalmanach G.

Eur J Biochem. 2001 May;268(9):2733-41.

19.

Probing the cruzain S2 recognition subsite: a kinetic and binding energy calculation study.

Polticelli F, Zaini G, Bolli A, Antonini G, Gradoni L, Ascenzi P.

Biochemistry. 2005 Mar 1;44(8):2781-9.

PMID:
15723522
20.

Quantitative structure-activity relationships for a series of inhibitors of cruzain from Trypanosoma cruzi: molecular modeling, CoMFA and CoMSIA studies.

Trossini GH, Guido RV, Oliva G, Ferreira EI, Andricopulo AD.

J Mol Graph Model. 2009 Aug;28(1):3-11. doi: 10.1016/j.jmgm.2009.03.001. Epub 2009 Mar 14.

PMID:
19376735
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