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Results: 1 to 20 of 210

1.
2.

Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration.

Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F.

Mol Pharmacol. 2004 Jan;65(1):56-67.

PMID:
14722237
[PubMed - indexed for MEDLINE]
Free Article
3.

The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.

Ren K, King MA, Liu J, Siemann J, Altman M, Meyers C, Hughes JA, Meyer EM.

Neuroscience. 2007 Aug 10;148(1):230-7. Epub 2007 Jul 20.

PMID:
17640819
[PubMed - indexed for MEDLINE]
4.

3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats.

Suzuki S, Kawamata J, Matsushita T, Matsumura A, Hisahara S, Takata K, Kitamura Y, Kem W, Shimohama S.

J Neurosci Res. 2013 Mar;91(3):462-71. doi: 10.1002/jnr.23160. Epub 2012 Dec 14.

PMID:
23239187
[PubMed - indexed for MEDLINE]
5.

Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptors.

Meyer EM, Kuryatov A, Gerzanich V, Lindstrom J, Papke RL.

J Pharmacol Exp Ther. 1998 Dec;287(3):918-25.

PMID:
9864273
[PubMed - indexed for MEDLINE]
Free Article
6.

alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation.

Ren K, Thinschmidt J, Liu J, Ai L, Papke RL, King MA, Hughes JA, Meyer EM.

Neuroscience. 2007 Mar 2;145(1):314-22. Epub 2007 Jan 9.

PMID:
17218065
[PubMed - indexed for MEDLINE]
7.

Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia.

Olincy A, Harris JG, Johnson LL, Pender V, Kongs S, Allensworth D, Ellis J, Zerbe GO, Leonard S, Stevens KE, Stevens JO, Martin L, Adler LE, Soti F, Kem WR, Freedman R.

Arch Gen Psychiatry. 2006 Jun;63(6):630-8.

PMID:
16754836
[PubMed - indexed for MEDLINE]
8.

Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice.

Stevens KE, Cornejo B, Adams CE, Zheng L, Yonchek J, Hoffman KL, Christians U, Kem WR.

Brain Res. 2010 Sep 17;1352:140-6. doi: 10.1016/j.brainres.2010.06.063. Epub 2010 Jul 3.

PMID:
20599427
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity.

Kihara T, Shimohama S, Sawada H, Kimura J, Kume T, Kochiyama H, Maeda T, Akaike A.

Ann Neurol. 1997 Aug;42(2):159-63.

PMID:
9266724
[PubMed - indexed for MEDLINE]
10.

Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist.

Kem WR.

Invert Neurosci. 1997 Sep-Dec;3(2-3):251-9. Review.

PMID:
9783447
[PubMed - indexed for MEDLINE]
11.

alpha7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in beta-amyloid infused rats.

Chen L, Yamada K, Nabeshima T, Sokabe M.

Neuropharmacology. 2006 Feb;50(2):254-68. Epub 2005 Dec 1.

PMID:
16324726
[PubMed - indexed for MEDLINE]
12.

Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors.

Kem WR, Mahnir VM, Papke RL, Lingle CJ.

J Pharmacol Exp Ther. 1997 Dec;283(3):979-92.

PMID:
9399967
[PubMed - indexed for MEDLINE]
Free Article
13.

Effects at a distance in alpha 7 nAChR selective agonists: benzylidene substitutions that regulate potency and efficacy.

Papke RL, Meyer EM, Lavieri S, Bollampally SR, Papke TA, Horenstein NA, Itoh Y, Porter Papke JK.

Neuropharmacology. 2004 Jun;46(7):1023-38.

PMID:
15081799
[PubMed - indexed for MEDLINE]
14.

Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.

Roncarati R, Scali C, Comery TA, Grauer SM, Aschmi S, Bothmann H, Jow B, Kowal D, Gianfriddo M, Kelley C, Zanelli U, Ghiron C, Haydar S, Dunlop J, Terstappen GC.

J Pharmacol Exp Ther. 2009 May;329(2):459-68. doi: 10.1124/jpet.108.150094. Epub 2009 Feb 17.

PMID:
19223665
[PubMed - indexed for MEDLINE]
Free Article
15.

In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease.

Bitner RS, Bunnelle WH, Decker MW, Drescher KU, Kohlhaas KL, Markosyan S, Marsh KC, Nikkel AL, Browman K, Radek R, Anderson DJ, Buccafusco J, Gopalakrishnan M.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):875-86. doi: 10.1124/jpet.110.167213. Epub 2010 May 26.

PMID:
20504913
[PubMed - indexed for MEDLINE]
Free Article
17.

GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue.

van Haaren F, Anderson KG, Haworth SC, Kem WR.

Pharmacol Biochem Behav. 1999 Oct;64(2):439-44.

PMID:
10515327
[PubMed - indexed for MEDLINE]
18.

Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine(3A) receptor.

Machu TK, Hamilton ME, Frye TF, Shanklin CL, Harris MC, Sun H, Tenner TE Jr, Soti FS, Kem WR.

J Pharmacol Exp Ther. 2001 Dec;299(3):1112-9.

PMID:
11714901
[PubMed - indexed for MEDLINE]
Free Article
19.

Septal innervation regulates the function of alpha7 nicotinic receptors in CA1 hippocampal interneurons.

Thinschmidt JS, Frazier CJ, King MA, Meyer EM, Papke RL.

Exp Neurol. 2005 Oct;195(2):342-52.

PMID:
16000197
[PubMed - indexed for MEDLINE]
20.

The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors.

Stokes C, Papke JK, Horenstein NA, Kem WR, McCormack TJ, Papke RL.

Mol Pharmacol. 2004 Jul;66(1):14-24.

PMID:
15213292
[PubMed - indexed for MEDLINE]
Free Article

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