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Spicamycin and KRN5500 induce apoptosis in myeloid and lymphoid cell lines with down-regulation of bcl-2 expression and modulation of promyelocytic leukemia protein.

Zhang WJ, Ohnishi K, Yoshida H, Pan L, Maksumova L, Muratkhodjaev F, Luo JM, Shigeno K, Fujisawa S, Naito K, Nakamura S, Shinjo K, Takeshita A, Ohno R.

Jpn J Cancer Res. 2000 Jun;91(6):604-11.


Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner.

Wang ZG, Rivi R, Delva L, König A, Scheinberg DA, Gambacorti-Passerini C, Gabrilove JL, Warrell RP Jr, Pandolfi PP.

Blood. 1998 Sep 1;92(5):1497-504.


A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation.

Morosetti R, Park DJ, Chumakov AM, Grillier I, Shiohara M, Gombart AF, Nakamaki T, Weinberg K, Koeffler HP.

Blood. 1997 Oct 1;90(7):2591-600.


KRN5500, a novel antitumor agent, induces apoptosis or cell differentiation in HL-60 cells.

Kawasaki K, Murakami T, Ita M, Sasaki K, Furukawa S.

Cytometry. 2000 Mar 1;39(3):211-6.


Monocytic differentiation of HL-60 promyelocytic leukemia cells correlates with the induction of Bcl-xL.

Chatterjee D, Han Z, Mendoza J, Goodglick L, Hendrickson EA, Pantazis P, Wyche JH.

Cell Growth Differ. 1997 Oct;8(10):1083-9.


Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells.

Elstner E, Linker-Israeli M, Umiel T, Le J, Grillier I, Said J, Shintaku IP, Krajewski S, Reed JC, Binderup L, Koeffler HP.

Cancer Res. 1996 Aug 1;56(15):3570-6.


[Apoptosis and regulation of expressions of apoptosis-related gene Bcl-2 and p53 induced by selenium dioxide in three leukemia cell lines].

Wang XH, Wei YM, Bai H, Ou JF, Lu JH, Zheng RL.

Di Yi Jun Yi Da Xue Xue Bao. 2004 Oct;24(10):1160-3. Chinese.


GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and bcl-2 in a murine myeloid cell line M1.

Tanaka H, Matsumura I, Nakajima K, Daino H, Sonoyama J, Yoshida H, Oritani K, Machii T, Yamamoto M, Hirano T, Kanakura Y.

Blood. 2000 Feb 15;95(4):1264-73.


Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia.

Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M, Estrov Z.

Blood. 2003 Jul 15;102(2):630-7. Epub 2003 Mar 27.


Differential gene expression in retinoic acid-induced differentiation of acute promyelocytic leukemia cells, NB4 and HL-60 cells.

Lee KH, Chang MY, Ahn JI, Yu DH, Jung SS, Choi JH, Noh YH, Lee YS, Ahn MJ.

Biochem Biophys Res Commun. 2002 Sep 6;296(5):1125-33.


KRN5500 induces apoptosis (PCD) of myeloid leukemia cell lines and patient blasts.

Stine KC, Warren BA, Saylors RL, Becton DL.

Leuk Res. 2000 Sep;24(9):741-9. Erratum in: Leuk Res 2000 Dec;24(12):1063.


Therapeutic targeting of nuclear receptor corepressor misfolding in acute promyelocytic leukemia cells with genistein.

Ng AP, Nin DS, Fong JH, Venkataraman D, Chen CS, Khan M.

Mol Cancer Ther. 2007 Aug;6(8):2240-8.


[In vitro effect of lovastatin on NB4 promyelocytic leukemia cells].

Guo F, Cen J, Chen Z.

Zhonghua Xue Ye Xue Za Zhi. 2001 Nov;22(11):584-8. Chinese.


Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia.

Konopleva M, Tsao T, Ruvolo P, Stiouf I, Estrov Z, Leysath CE, Zhao S, Harris D, Chang S, Jackson CE, Munsell M, Suh N, Gribble G, Honda T, May WS, Sporn MB, Andreeff M.

Blood. 2002 Jan 1;99(1):326-35.


The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms.

Zhang W, Ohnishi K, Shigeno K, Fujisawa S, Naito K, Nakamura S, Takeshita K, Takeshita A, Ohno R.

Leukemia. 1998 Sep;12(9):1383-91.

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