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Results: 1 to 20 of 95

1.

Mutations in the WRN gene in mice accelerate mortality in a p53-null background.

Lombard DB, Beard C, Johnson B, Marciniak RA, Dausman J, Bronson R, Buhlmann JE, Lipman R, Curry R, Sharpe A, Jaenisch R, Guarente L.

Mol Cell Biol. 2000 May;20(9):3286-91.

PMID:
10757812
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

p53-mediated apoptosis is attenuated in Werner syndrome cells.

Spillare EA, Robles AI, Wang XW, Shen JC, Yu CE, Schellenberg GD, Harris CC.

Genes Dev. 1999 Jun 1;13(11):1355-60.

PMID:
10364153
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.

Wang L, Ogburn CE, Ware CB, Ladiges WC, Youssoufian H, Martin GM, Oshima J.

Genetics. 2000 Jan;154(1):357-62.

PMID:
10628995
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Physical and functional interaction between p53 and the Werner's syndrome protein.

Blander G, Kipnis J, Leal JF, Yu CE, Schellenberg GD, Oren M.

J Biol Chem. 1999 Oct 8;274(41):29463-9.

PMID:
10506209
[PubMed - indexed for MEDLINE]
Free Article
5.

WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts.

Hisama FM, Chen YH, Meyn MS, Oshima J, Weissman SM.

Cancer Res. 2000 May 1;60(9):2372-6.

PMID:
10811112
[PubMed - indexed for MEDLINE]
Free Article
6.

Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.

Yu CE, Oshima J, Wijsman EM, Nakura J, Miki T, Piussan C, Matthews S, Fu YH, Mulligan J, Martin GM, Schellenberg GD.

Am J Hum Genet. 1997 Feb;60(2):330-41.

PMID:
9012406
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.

Kodama S, Kashino G, Suzuki K, Takatsuji T, Okumura Y, Oshimura M, Watanabe M, Barrett JC.

Cancer Res. 1998 Nov 15;58(22):5188-95.

PMID:
9823331
[PubMed - indexed for MEDLINE]
Free Article
8.

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.

Chen L, Huang S, Lee L, Davalos A, Schiestl RH, Campisi J, Oshima J.

Aging Cell. 2003 Aug;2(4):191-9.

PMID:
12934712
[PubMed - indexed for MEDLINE]
9.

Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.

Lebel M, Cardiff RD, Leder P.

Cancer Res. 2001 Mar 1;61(5):1816-9.

PMID:
11280729
[PubMed - indexed for MEDLINE]
Free Article
10.

Effect of age and apoptosis on the mouse homologue of the huWRN gene.

Wu J, He J, Mountz JD.

Mech Ageing Dev. 1998 Jun 1;103(1):27-44.

PMID:
9681877
[PubMed - indexed for MEDLINE]
11.

Asymmetry of DNA replication fork progression in Werner's syndrome.

Rodríguez-López AM, Jackson DA, Iborra F, Cox LS.

Aging Cell. 2002 Oct;1(1):30-9.

PMID:
12882351
[PubMed - indexed for MEDLINE]
12.

Camptothecin sensitivity in Werner syndrome fibroblasts as assessed by the COMET technique.

Lowe J, Sheerin A, Jennert-Burston K, Burton D, Ostler EL, Bird J, Green MH, Faragher RG.

Ann N Y Acad Sci. 2004 Jun;1019:256-9. Review.

PMID:
15247024
[PubMed - indexed for MEDLINE]
13.

Positional cloning of the Werner's syndrome gene.

Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD.

Science. 1996 Apr 12;272(5259):258-62.

PMID:
8602509
[PubMed - indexed for MEDLINE]
14.
15.

Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1.

Kawabe Y, Seki M, Seki T, Wang WS, Imamura O, Furuichi Y, Saitoh H, Enomoto T.

J Biol Chem. 2000 Jul 14;275(28):20963-6.

PMID:
10806190
[PubMed - indexed for MEDLINE]
Free Article
16.

Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.

Sinclair DA, Mills K, Guarente L.

Science. 1997 Aug 29;277(5330):1313-6.

PMID:
9271578
[PubMed - indexed for MEDLINE]
Free Article
17.
18.

LMNA mutations in atypical Werner's syndrome.

Chen L, Lee L, Kudlow BA, Dos Santos HG, Sletvold O, Shafeghati Y, Botha EG, Garg A, Hanson NB, Martin GM, Mian IS, Kennedy BK, Oshima J.

Lancet. 2003 Aug 9;362(9382):440-5.

PMID:
12927431
[PubMed - indexed for MEDLINE]
19.

p53 Modulates the exonuclease activity of Werner syndrome protein.

Brosh RM Jr, Karmakar P, Sommers JA, Yang Q, Wang XW, Spillare EA, Harris CC, Bohr VA.

J Biol Chem. 2001 Sep 14;276(37):35093-102. Epub 2001 Jun 26.

PMID:
11427532
[PubMed - indexed for MEDLINE]
Free Article
20.

A model for the phenotypic presentation of Werner's syndrome.

Ostler EL, Wallis CV, Sheerin AN, Faragher RG.

Exp Gerontol. 2002 Jan-Mar;37(2-3):285-92. Review.

PMID:
11772514
[PubMed - indexed for MEDLINE]

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