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Items: 1 to 20 of 127

1.

Identification of a novel aspartic protease (Asp 2) as beta-secretase.

Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G.

Mol Cell Neurosci. 1999 Dec;14(6):419-27.

2.

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.

Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME.

Nature. 1999 Dec 2;402(6761):533-7.

PMID:
10591213
3.

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Wu GX, Chen-Dodson E, Price E, Li Y, Xu M, Huang Q, Sardana MK, Hazuda DJ.

J Biol Chem. 2003 Jun 6;278(23):21286-94. Epub 2003 Mar 27.

4.

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M.

Science. 1999 Oct 22;286(5440):735-41.

5.

Cathepsin D displays in vitro beta-secretase-like specificity.

Chevallier N, Vizzavona J, Marambaud P, Baur CP, Spillantini M, Fulcrand P, Martinez J, Goedert M, Vincent JP, Checler F.

Brain Res. 1997 Mar 7;750(1-2):11-9.

PMID:
9098524
6.

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.

Nature. 1999 Apr 8;398(6727):513-7.

PMID:
10206644
7.

Purification and cloning of amyloid precursor protein beta-secretase from human brain.

Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V.

Nature. 1999 Dec 2;402(6761):537-40.

PMID:
10591214
8.

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.

Hussain I, Powell DJ, Howlett DR, Chapman GA, Gilmour L, Murdock PR, Tew DG, Meek TD, Chapman C, Schneider K, Ratcliffe SJ, Tattersall D, Testa TT, Southan C, Ryan DM, Simmons DL, Walsh FS, Dingwall C, Christie G.

Mol Cell Neurosci. 2000 Nov;16(5):609-19.

9.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
10.
11.

Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.

Sauder JM, Arthur JW, Dunbrack RL Jr.

J Mol Biol. 2000 Jul 7;300(2):241-8.

PMID:
10873463
12.

The beta-secretase, BACE: a prime drug target for Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2001 Oct;17(2):157-70. Review.

PMID:
11816789
13.

Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases.

Zhang W, Espinoza D, Hines V, Innis M, Mehta P, Miller DL.

Biochim Biophys Acta. 1997 Nov 27;1359(2):110-22.

14.

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.

Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9712-7.

15.

beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.

McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL.

Brain Res Mol Brain Res. 2001 Dec 16;97(1):103-13.

PMID:
11744168
16.

Identification of beta-secretase-like activity using a mass spectrometry-based assay system.

Grüninger-Leitch F, Berndt P, Langen H, Nelboeck P, Döbeli H.

Nat Biotechnol. 2000 Jan;18(1):66-70.

PMID:
10625394
18.

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.

Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ.

Biochemistry. 1999 Apr 13;38(15):4720-7.

PMID:
10200159
19.
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