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Items: 1 to 20 of 285

1.

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.

Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH.

Nature. 1999 Dec 9;402(6762):615-22.

PMID:
10604467
2.

Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain.

Takashima A, Murayama M, Yasutake K, Takahashi H, Yokoyama M, Ishiguro K.

Neurosci Lett. 2001 Jun 22;306(1-2):37-40.

PMID:
11403952
3.

Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.

Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T.

Biochem Biophys Res Commun. 2002 Nov 15;298(5):693-8.

PMID:
12419309
4.

The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator.

Hisanaga S, Saito T.

Neurosignals. 2003 Sep-Oct;12(4-5):221-9. Review.

PMID:
14673209
5.

Neurotoxicity induces cleavage of p35 to p25 by calpain.

Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH.

Nature. 2000 May 18;405(6784):360-4.

PMID:
10830966
6.
7.

Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells.

Shelton SB, Krishnamurthy P, Johnson GV.

J Neurosci Res. 2004 Apr 1;76(1):110-20.

PMID:
15048935
8.

Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons.

Li G, Faibushevich A, Turunen BJ, Yoon SO, Georg G, Michaelis ML, Dobrowsky RT.

J Neurochem. 2003 Jan;84(2):347-62.

9.

The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology.

Maccioni RB, Otth C, Concha II, Muñoz JP.

Eur J Biochem. 2001 Mar;268(6):1518-27. Review.

10.

Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene.

Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai LH.

J Neurosci. 2003 Apr 1;23(7):2769-78.

11.
12.

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro.

Town T, Zolton J, Shaffner R, Schnell B, Crescentini R, Wu Y, Zeng J, DelleDonne A, Obregon D, Tan J, Mullan M.

J Neurosci Res. 2002 Aug 1;69(3):362-72.

PMID:
12125077
13.

The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis.

Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T.

Biochem Biophys Res Commun. 2001 Feb 2;280(4):998-1002.

PMID:
11162625
14.

Cdk5 as a drug target for the treatment of Alzheimer's disease.

Lau LF, Seymour PA, Sanner MA, Schachter JB.

J Mol Neurosci. 2002 Dec;19(3):267-73. Review.

PMID:
12540052
15.

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles.

Tandon A, Yu H, Wang L, Rogaeva E, Sato C, Chishti MA, Kawarai T, Hasegawa H, Chen F, Davies P, Fraser PE, Westaway D, St George-Hyslop PH.

J Neurochem. 2003 Aug;86(3):572-81.

16.

Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells.

Nath R, Davis M, Probert AW, Kupina NC, Ren X, Schielke GP, Wang KK.

Biochem Biophys Res Commun. 2000 Jul 21;274(1):16-21. Erratum in: Biochem Biophys Res Commun 2000 Sep 16;276(1):390.

PMID:
10903889
17.

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice.

Bian F, Nath R, Sobocinski G, Booher RN, Lipinski WJ, Callahan MJ, Pack A, Wang KK, Walker LC.

J Comp Neurol. 2002 May 6;446(3):257-66.

PMID:
11932941
18.

Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5.

Kesavapany S, Zheng YL, Amin N, Pant HC.

Biotechnol J. 2007 Aug;2(8):978-87. Review.

PMID:
17526058
19.

A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons.

Zheng YL, Kesavapany S, Gravell M, Hamilton RS, Schubert M, Amin N, Albers W, Grant P, Pant HC.

EMBO J. 2005 Jan 12;24(1):209-20. Epub 2004 Dec 9.

20.

Cyclin-dependent kinase 5--a neuronal killer?

Guo Q.

Sci Aging Knowledge Environ. 2003 Dec 17;2003(50):pe36. Review.

PMID:
14681576
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