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Results: 1 to 20 of 152

1.

Intracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine).

Balzarini J, Naesens L, Aquaro S, Knispel T, Perno C, De Clercq E, Meier C.

Mol Pharmacol. 1999 Dec;56(6):1354-61.

PMID:
10570065
[PubMed - indexed for MEDLINE]
Free Article
2.

Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP.

Balzarini J, Aquaro S, Knispel T, Rampazzo C, Bianchi V, Perno CF, De Clercq E, Meier C.

Mol Pharmacol. 2000 Nov;58(5):928-35.

PMID:
11040039
[PubMed - indexed for MEDLINE]
Free Article
4.

Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.

Saboulard D, Naesens L, Cahard D, Salgado A, Pathirana R, Velazquez S, McGuigan C, De Clercq E, Balzarini J.

Mol Pharmacol. 1999 Oct;56(4):693-704.

PMID:
10496951
[PubMed - indexed for MEDLINE]
Free Article
6.

Novel approaches for designing 5'-O-ester prodrugs of 3'-azido-2', 3'-dideoxythymidine (AZT).

Parang K, Wiebe LI, Knaus EE.

Curr Med Chem. 2000 Oct;7(10):995-1039. Review.

PMID:
10911016
[PubMed - indexed for MEDLINE]
7.

Intracellular metabolism and pharmacokinetics of 5'-hydrogenphosphonate of 3'-azido-2',3'-dideoxythymidine, a prodrug of 3'-azido-2',3'-dideoxythymidine.

Skoblov Y, Karpenko I, Shirokova E, Popov K, Andronova V, Galegov G, Kukhanova M.

Antiviral Res. 2004 Aug;63(2):107-13.

PMID:
15302139
[PubMed - indexed for MEDLINE]
8.

AZT and AZT-monophosphate prodrugs incorporating HIV-protease substrate fragment: synthesis and evaluation as specific drug delivery systems.

Liotard JF, Mehiri M, Di Giorgio A, Boggetto N, Reboud-Ravaux M, Aubertin AM, Condom R, Patino N.

Antivir Chem Chemother. 2006;17(4):193-213.

PMID:
17066898
[PubMed - indexed for MEDLINE]
9.

Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes.

Drake RR, McMasters R, Krisa S, Hume SD, Rechtin TM, Saylors RL, Chiang Y, Govindarajan R, Munshi NC.

Antiviral Res. 1997 Aug;35(3):177-85.

PMID:
9298757
[PubMed - indexed for MEDLINE]
10.

Pharmacokinetics of bis(t-butyl-SATE)-AZTMP, a bispivaloylthioethyl prodrug for intracellular delivery of zidovudine monophosphate, in mice.

Tan X, Boudinot FD, Chu CK, Egron D, Perigaud C, Gosselin G, Imbach JL.

Antivir Chem Chemother. 2000 May;11(3):203-11.

PMID:
10901291
[PubMed - indexed for MEDLINE]
12.

3'-Azido-3'-deoxythymidine cytotoxicity and metabolism in the human colon tumor cell line HCT-8.

Darnowski JW, Goulette FA.

Biochem Pharmacol. 1994 Nov 1;48(9):1797-805.

PMID:
7980649
[PubMed - indexed for MEDLINE]
13.

Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP.

Ostermann N, Lavie A, Padiyar S, Brundiers R, Veit T, Reinstein J, Goody RS, Konrad M, Schlichting I.

J Mol Biol. 2000 Nov 17;304(1):43-53.

PMID:
11071809
[PubMed - indexed for MEDLINE]
14.

Amino acid phosphoramidate monoesters of 3'-azido-3'-deoxythymidine: relationship between antiviral potency and intracellular metabolism.

Chang S, Griesgraber GW, Southern PJ, Wagner CR.

J Med Chem. 2001 Jan 18;44(2):223-31.

PMID:
11170632
[PubMed - indexed for MEDLINE]
15.
16.
17.

cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.

Meier C, Lorey M, De Clercq E, Balzarini J.

J Med Chem. 1998 Apr 23;41(9):1417-27.

PMID:
9554875
[PubMed - indexed for MEDLINE]
18.

Mononucleoside phosphotriester derivatives with S-acyl-2-thioethyl bioreversible phosphate-protecting groups: intracellular delivery of 3'-azido-2',3'-dideoxythymidine 5'-monophosphate.

Lefebvre I, Périgaud C, Pompon A, Aubertin AM, Girardet JL, Kirn A, Gosselin G, Imbach JL.

J Med Chem. 1995 Sep 29;38(20):3941-50.

PMID:
7562927
[PubMed - indexed for MEDLINE]
19.

Synthesis, anti-HIV activity and stability studies of 3'-azido-2',3'-dideoxythymidine 5'-fluorophosphate.

Egron D, Arzumanov AA, Dyatkina NB, Krayevsky A, Imbach JL, Aubertin AM, Gosselin G, Périgaud C.

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):983-4.

PMID:
10432725
[PubMed - indexed for MEDLINE]
20.

Comparison of rates of intracellular metabolism of zidovudine in human and primate peripheral blood mononuclear cells.

Qian M, Chandrasena G, Ho RJ, Unadkat JD.

Antimicrob Agents Chemother. 1994 Oct;38(10):2398-403.

PMID:
7840577
[PubMed - indexed for MEDLINE]
Free PMC Article

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