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Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity.

You Z, Komamura Y, Ishimi Y.

Mol Cell Biol. 1999 Dec;19(12):8003-15.


Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex.

You Z, Ishimi Y, Masai H, Hanaoka F.

J Biol Chem. 2002 Nov 8;277(45):42471-9. Epub 2002 Aug 30.


Mcm subunits can assemble into two different active unwinding complexes.

Kanter DM, Bruck I, Kaplan DL.

J Biol Chem. 2008 Nov 7;283(45):31172-82. doi: 10.1074/jbc.M804686200. Epub 2008 Sep 17.


Electron microscopic observation and single-stranded DNA binding activity of the Mcm4,6,7 complex.

Sato M, Gotow T, You Z, Komamura-Kohno Y, Uchiyama Y, Yabuta N, Nojima H, Ishimi Y.

J Mol Biol. 2000 Jul 14;300(3):421-31.


A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.

Ishimi Y.

J Biol Chem. 1997 Sep 26;272(39):24508-13. Erratum in: J Biol Chem 1998 Sep 4;273(36):23616.


Phosphorylation of MCM4 at sites inactivating DNA helicase activity of the MCM4-MCM6-MCM7 complex during Epstein-Barr virus productive replication.

Kudoh A, Daikoku T, Ishimi Y, Kawaguchi Y, Shirata N, Iwahori S, Isomura H, Tsurumi T.

J Virol. 2006 Oct;80(20):10064-72.


Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.

You Z, Masai H.

J Biol Chem. 2008 Sep 5;283(36):24469-77. doi: 10.1074/jbc.M803212200. Epub 2008 Jul 7.


The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.

Bochman ML, Schwacha A.

Nucleic Acids Res. 2010 Oct;38(18):6078-88. doi: 10.1093/nar/gkq422. Epub 2010 May 19.


DNA binding and helicase actions of mouse MCM4/6/7 helicase.

You Z, Masai H.

Nucleic Acids Res. 2005 May 25;33(9):3033-47. Print 2005.


Effect of an MCM4 mutation that causes tumours in mouse on human MCM4/6/7 complex formation.

Watanabe E, Ohara R, Ishimi Y.

J Biochem. 2012 Aug;152(2):191-8. doi: 10.1093/jb/mvs060. Epub 2012 Jun 4.


ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes.

Stead BE, Sorbara CD, Brandl CJ, Davey MJ.

J Mol Biol. 2009 Aug 14;391(2):301-13. doi: 10.1016/j.jmb.2009.06.038. Epub 2009 Jun 21.


Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.

Ramer MD, Suman ES, Richter H, Stanger K, Spranger M, Bieberstein N, Duncker BP.

J Biol Chem. 2013 May 24;288(21):14926-35. doi: 10.1074/jbc.M112.392910. Epub 2013 Apr 2.


Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks.

Nitani N, Yadani C, Yabuuchi H, Masukata H, Nakagawa T.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12973-8. doi: 10.1073/pnas.0805307105. Epub 2008 Aug 27.


Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2.

Ishimi Y, Komamura-Kohno Y, You Z, Omori A, Kitagawa M.

J Biol Chem. 2000 May 26;275(21):16235-41.


Thymine-rich single-stranded DNA activates Mcm4/6/7 helicase on Y-fork and bubble-like substrates.

You Z, Ishimi Y, Mizuno T, Sugasawa K, Hanaoka F, Masai H.

EMBO J. 2003 Nov 17;22(22):6148-60.


Interaction of heliquinomycin with single-stranded DNA inhibits MCM4/6/7 helicase.

Sugiyama T, Chino M, Tsurimoto T, Nozaki N, Ishimi Y.

J Biochem. 2012 Feb;151(2):129-37. doi: 10.1093/jb/mvr130. Epub 2011 Oct 24.


Identification and characterization of a novel component of the human minichromosome maintenance complex.

Sakwe AM, Nguyen T, Athanasopoulos V, Shire K, Frappier L.

Mol Cell Biol. 2007 Apr;27(8):3044-55. Epub 2007 Feb 12.

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