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Results: 1 to 20 of 166

1.

Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition.

Marnett LJ, Rowlinson SW, Goodwin DC, Kalgutkar AS, Lanzo CA.

J Biol Chem. 1999 Aug 13;274(33):22903-6. Review. No abstract available.

PMID:
10438452
[PubMed - indexed for MEDLINE]
Free Article
2.

The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins.

Garavito RM, DeWitt DL.

Biochim Biophys Acta. 1999 Nov 23;1441(2-3):278-87. Review.

PMID:
10570255
[PubMed - indexed for MEDLINE]
Free Article
3.

COX in a crystal ball: current status and future promise of prostaglandin research.

FitzGerald GA, Loll P.

J Clin Invest. 2001 Jun;107(11):1335-7. Review. No abstract available.

PMID:
11390412
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The structures of prostaglandin endoperoxide H synthases-1 and -2.

Garavito RM, Malkowski MG, DeWitt DL.

Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:129-52. Review.

PMID:
12432914
[PubMed - indexed for MEDLINE]
5.

Structural approach for COX-2 inhibition.

Michaux C, Charlier C.

Mini Rev Med Chem. 2004 Aug;4(6):603-15. Review.

PMID:
15279594
[PubMed - indexed for MEDLINE]
6.

Structural basis for selective inhibition of COX-2 by nimesulide.

Fabiola GF, Pattabhi V, Nagarajan K.

Bioorg Med Chem. 1998 Dec;6(12):2337-44.

PMID:
9925294
[PubMed - indexed for MEDLINE]
7.

Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol.

Kozak KR, Prusakiewicz JJ, Rowlinson SW, Schneider C, Marnett LJ.

J Biol Chem. 2001 Aug 10;276(32):30072-7. Epub 2001 Jun 11.

PMID:
11402053
[PubMed - indexed for MEDLINE]
Free Article
8.

Structure, function and inhibition of cyclo-oxygenases.

Marnett LJ.

Ernst Schering Res Found Workshop. 2000;(31):65-83. Review. No abstract available.

PMID:
10943328
[PubMed - indexed for MEDLINE]
9.

Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide.

Kozak KR, Prusakiewicz JJ, Rowlinson SW, Prudhomme DR, Marnett LJ.

Biochemistry. 2003 Aug 5;42(30):9041-9.

PMID:
12885237
[PubMed - indexed for MEDLINE]
10.

Analysis of cyclooxygenase-substrate interactions using stereospecifically-labeled arachidonic acids.

Schneider C, Boeglin WE, Brash AR.

Adv Exp Med Biol. 2002;507:49-53. No abstract available.

PMID:
12664563
[PubMed - indexed for MEDLINE]
11.

Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors.

Park CH, Siomboing X, Yous S, Gressier B, Luyckx M, Chavatte P.

Eur J Med Chem. 2002 Jun;37(6):461-8.

PMID:
12204472
[PubMed - indexed for MEDLINE]
12.

Regulation of cyclo-oxygenase-2.

Stack E, DuBois RN.

Best Pract Res Clin Gastroenterol. 2001 Oct;15(5):787-800. Review.

PMID:
11566041
[PubMed - indexed for MEDLINE]
13.

Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid.

Thuresson ED, Lakkides KM, Rieke CJ, Sun Y, Wingerd BA, Micielli R, Mulichak AM, Malkowski MG, Garavito RM, Smith WL.

J Biol Chem. 2001 Mar 30;276(13):10347-57. Epub 2000 Dec 19.

PMID:
11121412
[PubMed - indexed for MEDLINE]
Free Article
14.

Rationale for the observed COX-2/COX-1 selectivity of celecoxib from Monte Carlo simulations.

Price ML, Jorgensen WL.

Bioorg Med Chem Lett. 2001 Jun 18;11(12):1541-4.

PMID:
11412976
[PubMed - indexed for MEDLINE]
15.

Cyclooxygenase isoenzymes and newer therapeutic potential for selective COX-2 inhibitors.

Kulkarni SK, Jain NK, Singh A.

Methods Find Exp Clin Pharmacol. 2000 Jun;22(5):291-8. Review.

PMID:
11031730
[PubMed - indexed for MEDLINE]
16.

Picture story. COX complexes.

Feng H.

Nat Struct Biol. 2000 Jun;7(6):448. No abstract available.

PMID:
10881188
[PubMed - indexed for MEDLINE]
17.

Fatty-acid substrate interactions with cyclo-oxygenases.

Smith WL, Rieke CJ, Thuresson ED, Mulichak AM, Garavito RM.

Ernst Schering Res Found Workshop. 2000;(31):53-64. Review. No abstract available.

PMID:
10943327
[PubMed - indexed for MEDLINE]
18.

Mechanism of inhibition of novel COX-2 inhibitors.

Gierse J, Kurumbail R, Walker M, Hood B, Monahan J, Pawlitz J, Stegeman R, Stevens A, Kiefer J, Koboldt C, Moreland K, Rowlinson S, Marnett L, Pierce J, Carter J, Talley J, Isakson P, Seibert K.

Adv Exp Med Biol. 2002;507:365-9. No abstract available.

PMID:
12664611
[PubMed - indexed for MEDLINE]
19.

Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.

Riendeau D, Percival MD, Brideau C, Charleson S, Dubé D, Ethier D, Falgueyret JP, Friesen RW, Gordon R, Greig G, Guay J, Mancini J, Ouellet M, Wong E, Xu L, Boyce S, Visco D, Girard Y, Prasit P, Zamboni R, Rodger IW, Gresser M, Ford-Hutchinson AW, Young RN, Chan CC.

J Pharmacol Exp Ther. 2001 Feb;296(2):558-66.

PMID:
11160644
[PubMed - indexed for MEDLINE]
Free Article
20.

Prostaglandin endoperoxide synthases-1 and -2.

Otto JC, Smith WL.

J Lipid Mediat Cell Signal. 1995 Oct;12(2-3):139-56. Review. No abstract available.

PMID:
8777562
[PubMed - indexed for MEDLINE]

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