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10364643,23146133,15036621,25524955,15211066,10448801,15152345,25162367,15477624,20479234,15956169,18322386,10944562,11110538,20678545,15557508,8669492,16699282,12457072,24613704,16406347,27410431,16103669,26141491,19164761,16254428,20930301,15365129,16946187,18555606,20007524,12876259,26981880,9728943,12218647,12205106,24625799,15767511,17541051,18786162,19339712,10737693,9619150,16645276,17596691,26877211,15702779,15522251,21493755,15596614,33167837,16399213,10835442,12552039,8614504,20693633,15096402,19013250,17374951,16945218,9667603,15545327,20060049,8618665,23948881,25624419,31199015,22531427,35317127,18843182,18334913,11281316,23587637,25754878,16606914,31575706,29548722,24944262,20705142,33397450,9708956,14609807,21297273,12405544,9052712,10563634,33166415,31159873,31006219,25988463,27556935,15505155,11673590,27228100,27705964,16956959,9153643,9848808,24878738,14688411,11756600,29782824,24117117,15326261,16513038,11889238,31102429,9073034,36226340,10362893,11790634,31831047,21098974,23356599,21502596,10403716,11445269,11893839,30798004,32048144,16421115,34311631,10668704,10593304,12023428,11835377,23647000,27176479,21892657,27259692,29356827,9221969,21163916,20065135,35354468,32304722,19605830,24411483,10784244,10751265,29852871,35142437,9520135,34266503,10609670,24659793,30866553,25365563,8846237,19349226,10981753,9106542,15249617,24453080,21357878,9876966,9524800,24914687,10891924,10625715,11311499,10408560,12719629,31704790,15370375,11303757,28229235,11157409,24582705,19940480,29911873,18458218,24929969,26161964,11172628,33648793,25304991,11893834,16841077,28176662,15184602,32572010,27677546,12682309,32664228,35354197,30136422,24475827,11916953,29458426,11072138,34743630,9733229,18195144,16598702,19308307,32506713,12221169,11245719,11904138,9780089,9436725,9625186,29637601,20306566,22405043,23541188,16473977,31587263,15048896,11893833,12774299,27785756,14989602,11445633,23887281,12405546,25738563,21593560,12963757,35899859,14512715,27321987,11032626,27173368,16107349,10436099,21803164,9280168,21357834,10886308,32379048,22544617,21676498,28287184,9539410,29883038,23216585,31865187,30341156,22828738,27911297,23896613,34721251,12959500,31760549,22102296,19629426,26610898,18318693,10601411,19744893,15365149,35471691,26560730,9754953,11939896,9074395,7609910,35572149,28987665,20335123,23552688,35661582,23407718,30983990,28692819,29376853,24313901,26986748,27033053,19484916,18574133,10932283,10668701,10705163,11756601,23242623,11305851,10822435,30006015,9404942,34310026,10794191,20880354,23109152,15345810,12533090,29544979,12502505,28448944,16131735,12003251,15201477,12212776,14512714,33148345,22206848,10420066,8993485,21324265,33338617,10026381,16085790,9007313,28747136,11072144,8596288,19357304,33603015,20375505,34870911,24359501,20691792,11448080,10961672,19554612,36919310,28706481,11949718,35720695,35232006,12480082,32311609,33938146,17464526,21537391,11939895,15007124,31654640,8761956,20031276,31919381,12566949,15919549,15249619,24986007,35122970,10208278,10555661,33454416,16445161,15477533,9121689,29416324,24349461,22927174,7498406,27168072,27777343,34487993,9850916,11993532,34078163,23275593,11746653,19625744,10654093,24659241,9932938,10367700,29189302,8624094,11081958,14709760,24434095,27683909,10599765,10202267,27143429,16170092,34614170,28848214,26302887,23569459,10711572,17911980,21184197,14681915,11180489,34864669,27174891,27703028,33716715,28365321,33208795,14728627,28874525,33342004,31066941,33301284,10408574,32961338,34136636,32586852,10534277,35691047,10751272,17988893,28940184,18430999,31164996,20937951,31113760,19784754,31920926,27801937,11598309,21398096,26306786,16056141,30587010,12145969,9533192,9920358,35001031,19571734,26542262,21555637,16627465,10746597,31836585,33015312,36504632,28623677,12023438,20308781,29889068,28761928,2322131,15202770,15184597,29695149,27479921,28209315,31524019,34194377,30125600,11094110,19958568,9565840,8915040,33331535,12003753,27911292,30388556,31806724,20625166,12714110,18395955,17548776,12558712,27620974,30293724,26287823,33403644,36999481,27240852,9472879,21443344,33603659,33312717,8992370,12107813,21152065,34744974,32581766,11171894,8559365,19150504,35847686,21172323,30240575,34541286,11160955,11770901,12297572,12470696,24321557,26854173,23036026,12636463,22825739,12446932,34143234,19202337,35303671,23650207,32521990,30830563,21531480,32647745,34933635,17101833,9121715,31126628,19364947,30175228,9777422,33057949,30890889,15643038,11069266,9872376,28578785,20389122,19933973,27907913,31424400,34569714,32903525,31798303,17431011,11790642,9213073,33688582,25872513,33651951,30511009,9844033,28212814,25538616,8576522,12151837,20139337,10850738,24746929,30827874,31563540,11342683,29414991,30777379,30425186,35783453,31284182,9139296,20576093,11241722,29422646,6410835,32522370,12391342,10604434,34205498,32564151,36689643,29528855,24961307,7658797,25799927,33495373,7639073,6600923,573407,11072260,22407276,11697577,3673655,12405542,22821632,36633304,30550413,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Inheritance of the ApoE epsilon4 allele increases the rate of brain atrophy in dementia patients.

Wahlund LO, Julin P, Lannfelt L, Lindqvist J, Svensson L. Wahlund LO, et al. Dement Geriatr Cogn Disord. 1999 Jul-Aug;10(4):262-8. doi: 10.1159/000017130. Dement Geriatr Cogn Disord. 1999. PMID: 10364643 Clinical Trial.

Association between white matter hyperintensity severity and cognitive impairment according to the presence of the apolipoprotein E (APOE) ε4 allele in the elderly: retrospective analysis of data from the CREDOS study.

Son SJ, Lee KS, Lee Y, Baek JH, Choi SH, Na DL, Seo SW, Oh BH, Hong CH. Son SJ, et al. J Clin Psychiatry. 2012 Dec;73(12):1555-62. doi: 10.4088/JCP.12m07702. Epub 2012 Oct 30. J Clin Psychiatry. 2012. PMID: 23146133

APOE and modulation of Alzheimer's and frontotemporal dementia.

Boccardi M, Sabattoli F, Testa C, Beltramello A, Soininen H, Frisoni GB. Boccardi M, et al. Neurosci Lett. 2004 Feb 19;356(3):167-70. doi: 10.1016/j.neulet.2003.11.042. Neurosci Lett. 2004. PMID: 15036621

Cognition, brain atrophy, and cerebrospinal fluid biomarkers changes from preclinical to dementia stage of Alzheimer's disease and the influence of apolipoprotein e.

Susanto TA, Pua EP, Zhou J; Alzheimer’s Disease Neuroimaging Initiative. Susanto TA, et al. J Alzheimers Dis. 2015;45(1):253-68. doi: 10.3233/JAD-142451. J Alzheimers Dis. 2015. PMID: 25524955

Apolipoprotein E epsilon4 allele differently affects the patterns of neuropsychological presentation in early- and late-onset Alzheimer's disease patients.

Marra C, Bizzarro A, Daniele A, De Luca L, Ferraccioli M, Valenza A, Brahe C, Tiziano FD, Gainotti G, Masullo C. Marra C, et al. Dement Geriatr Cogn Disord. 2004;18(2):125-31. doi: 10.1159/000079191. Epub 2004 Jun 18. Dement Geriatr Cogn Disord. 2004. PMID: 15211066

Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias.

Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, Morris CM, O'Brien JT. Barber R, et al. Arch Neurol. 1999 Aug;56(8):961-5. doi: 10.1001/archneur.56.8.961. Arch Neurol. 1999. PMID: 10448801

[Dementia and cognitive impairment pattern: its association with epsilon4 allele of apolipoprotein E gene].

Rosich-Estragó M, Figuera-Terré L, Mulet-Pérez B, Arrufat-Cardús MT, Pascual San Emeterio A, Arbeola-Rigau I, Labad-Alquézar A, Vilella-Cuadrada E. Rosich-Estragó M, et al. Rev Neurol. 2004 May 1-15;38(9):801-7. Rev Neurol. 2004. PMID: 15152345 Free article. Spanish.

Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease.

Lautner R, Palmqvist S, Mattsson N, Andreasson U, Wallin A, Pålsson E, Jakobsson J, Herukka SK, Owenius R, Olsson B, Hampel H, Rujescu D, Ewers M, Landén M, Minthon L, Blennow K, Zetterberg H, Hansson O; Alzheimer’s Disease Neuroimaging Initiative. Lautner R, et al. JAMA Psychiatry. 2014 Oct;71(10):1183-91. doi: 10.1001/jamapsychiatry.2014.1060. JAMA Psychiatry. 2014. PMID: 25162367

Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging.

Hsiung GY, Sadovnick AD, Feldman H. Hsiung GY, et al. CMAJ. 2004 Oct 12;171(8):863-7. doi: 10.1503/cmaj.1031789. CMAJ. 2004. PMID: 15477624 Free PMC article.

Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease.

Wolk DA, Dickerson BC; Alzheimer's Disease Neuroimaging Initiative. Wolk DA, et al. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10256-61. doi: 10.1073/pnas.1001412107. Epub 2010 May 17. Proc Natl Acad Sci U S A. 2010. PMID: 20479234 Free PMC article.

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