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Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures.

Bell SM, Schreiner CM, Schultheis PJ, Miller ML, Evans RL, Vorhees CV, Shull GE, Scott WJ.

Am J Physiol. 1999 Apr;276(4 Pt 1):C788-95.


Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cells.

Brown DA, Melvin JE, Yule DI.

Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G804-12. Epub 2003 Jul 3.


Decreased neuronal death in Na+/H+ exchanger isoform 1-null mice after in vitro and in vivo ischemia.

Luo J, Chen H, Kintner DB, Shull GE, Sun D.

J Neurosci. 2005 Dec 7;25(49):11256-68.


Intracellular pH regulation of CA1 neurons in Na(+)/H(+) isoform 1 mutant mice.

Yao H, Ma E, Gu XQ, Haddad GG.

J Clin Invest. 1999 Sep;104(5):637-45.


Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion.

Schultheis PJ, Clarke LL, Meneton P, Harline M, Boivin GP, Stemmermann G, Duffy JJ, Doetschman T, Miller ML, Shull GE.

J Clin Invest. 1998 Mar 15;101(6):1243-53.


Differential expression and regulation of Na(+)/H(+) exchanger isoforms in rabbit parietal and mucous cells.

Rossmann H, Sonnentag T, Heinzmann A, Seidler B, Bachmann O, Vieillard-Baron D, Gregor M, Seidler U.

Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G447-58.


Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice.

Cox GA, Lutz CM, Yang CL, Biemesderfer D, Bronson RT, Fu A, Aronson PS, Noebels JL, Frankel WN.

Cell. 1997 Oct 3;91(1):139-48. Erratum in: Cell 1997 Dec 12;91(6):861.


Targeted disruption of the Nhe1 gene fails to inhibit beta(1)-adrenergic receptor-induced parotid gland hypertrophy.

Melvin JE, Nguyen HV, Nehrke K, Schreiner CM, Ten Hagen KG, Scott W.

Am J Physiol Gastrointest Liver Physiol. 2001 Apr;280(4):G694-700.


Increased tolerance to oxygen and glucose deprivation in astrocytes from Na(+)/H(+) exchanger isoform 1 null mice.

Kintner DB, Su G, Lenart B, Ballard AJ, Meyer JW, Ng LL, Shull GE, Sun D.

Am J Physiol Cell Physiol. 2004 Jul;287(1):C12-21. Epub 2004 Mar 10.


The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium.

Schneider L, Stock CM, Dieterich P, Jensen BH, Pedersen LB, Satir P, Schwab A, Christensen ST, Pedersen SF.

J Cell Biol. 2009 Apr 6;185(1):163-76. doi: 10.1083/jcb.200806019.


Increased Na(+)/H(+) exchanger isoform 1 activity in spontaneously hypertensive rats: lack of mutations within the coding region of NHE1.

Orlov SN, Adarichev VA, Devlin AM, Maximova NV, Sun YL, Tremblay J, Dominiczak AF, Postnov YV, Hamet P.

Biochim Biophys Acta. 2000 Feb 21;1500(2):169-80.


Defective fluid secretion and NaCl absorption in the parotid glands of Na+/H+ exchanger-deficient mice.

Park K, Evans RL, Watson GE, Nehrke K, Richardson L, Bell SM, Schultheis PJ, Hand AR, Shull GE, Melvin JE.

J Biol Chem. 2001 Jul 20;276(29):27042-50. Epub 2001 May 17.


The Na+/H+ exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation.

Bachmann O, Riederer B, Rossmann H, Groos S, Schultheis PJ, Shull GE, Gregor M, Manns MP, Seidler U.

Am J Physiol Gastrointest Liver Physiol. 2004 Jul;287(1):G125-33. Epub 2004 Feb 12.


Mice with a null mutation in the NHE1 Na+-H+ exchanger are resistant to cardiac ischemia-reperfusion injury.

Wang Y, Meyer JW, Ashraf M, Shull GE.

Circ Res. 2003 Oct 17;93(8):776-82. Epub 2003 Sep 11.


NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells.

Praetorius J, Andreasen D, Jensen BL, Ainsworth MA, Friis UG, Johansen T.

Am J Physiol Gastrointest Liver Physiol. 2000 Feb;278(2):G197-206.


Increased neuronal excitability and seizures in the Na(+)/H(+) exchanger null mutant mouse.

Gu XQ, Yao H, Haddad GG.

Am J Physiol Cell Physiol. 2001 Aug;281(2):C496-503.


Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: a role for ER stress?

Cook AR, Bardswell SC, Pretheshan S, Dighe K, Kanaganayagam GS, Jabr RI, Merkle S, Marber MS, Engelhardt S, Avkiran M.

J Mol Cell Cardiol. 2009 Feb;46(2):225-33. doi: 10.1016/j.yjmcc.2008.10.013. Epub 2008 Nov 5.


Expression of Na+/H+ and HCO3- -dependent transporters in Na+/H+ exchanger isoform 1 null mutant mouse brain.

Xue J, Douglas RM, Zhou D, Lim JY, Boron WF, Haddad GG.

Neuroscience. 2003;122(1):37-46.

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