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The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer.

Callaghan J, Simonsen A, Gaullier JM, Toh BH, Stenmark H.

Biochem J. 1999 Mar 1;338 ( Pt 2):539-43.


Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1.

Lawe DC, Chawla A, Merithew E, Dumas J, Carrington W, Fogarty K, Lifshitz L, Tuft R, Lambright D, Corvera S.

J Biol Chem. 2002 Mar 8;277(10):8611-7. Epub 2001 Oct 15.


Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes.

Mills IG, Jones AT, Clague MJ.

Curr Biol. 1998 Jul 16;8(15):881-4.


Direct interaction of EEA1 with Rab5b.

Callaghan J, Nixon S, Bucci C, Toh BH, Stenmark H.

Eur J Biochem. 1999 Oct 1;265(1):361-6.


Relationships between EEA1 binding partners and their role in endosome fusion.

Mills IG, Urbé S, Clague MJ.

J Cell Sci. 2001 May;114(Pt 10):1959-65.


EEA1 links PI(3)K function to Rab5 regulation of endosome fusion.

Simonsen A, Lippé R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H.

Nature. 1998 Jul 30;394(6692):494-8.


Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion.

Gournier H, Stenmark H, Rybin V, Lippé R, Zerial M.

EMBO J. 1998 Apr 1;17(7):1930-40.


Interaction of the EEA1 FYVE finger with phosphatidylinositol 3-phosphate and early endosomes. Role of conserved residues.

Gaullier JM, Ronning E, Gillooly DJ, Stenmark H.

J Biol Chem. 2000 Aug 11;275(32):24595-600.


Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger.

Stenmark H, Aasland R, Toh BH, D'Arrigo A.

J Biol Chem. 1996 Sep 27;271(39):24048-54.


EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif.

Mu FT, Callaghan JM, Steele-Mortimer O, Stenmark H, Parton RG, Campbell PL, McCluskey J, Yeo JP, Tock EP, Toh BH.

J Biol Chem. 1995 Jun 2;270(22):13503-11.


Multivalent endosome targeting by homodimeric EEA1.

Dumas JJ, Merithew E, Sudharshan E, Rajamani D, Hayes S, Lawe D, Corvera S, Lambright DG.

Mol Cell. 2001 Nov;8(5):947-58.


The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking.

Kauppi M, Simonsen A, Bremnes B, Vieira A, Callaghan J, Stenmark H, Olkkonen VM.

J Cell Sci. 2002 Mar 1;115(Pt 5):899-911.


Role of Rab5 in the recruitment of hVps34/p150 to the early endosome.

Murray JT, Panaretou C, Stenmark H, Miaczynska M, Backer JM.

Traffic. 2002 Jun;3(6):416-27.


Cell-cycle-dependent binding kinetics for the early endosomal tethering factor EEA1.

Bergeland T, Haugen L, Landsverk OJ, Stenmark H, Bakke O.

EMBO Rep. 2008 Feb;9(2):171-8. doi: 10.1038/sj.embor.7401152. Epub 2008 Jan 11.


The Rab5 effector EEA1 interacts directly with syntaxin-6.

Simonsen A, Gaullier JM, D'Arrigo A, Stenmark H.

J Biol Chem. 1999 Oct 8;274(41):28857-60.


FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes.

Raiborg C, Bremnes B, Mehlum A, Gillooly DJ, D'Arrigo A, Stang E, Stenmark H.

J Cell Sci. 2001 Jun;114(Pt 12):2255-63.


Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5.

Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M.

EMBO J. 1998 Apr 1;17(7):1941-51.


The Rab5 effector EEA1 is a core component of endosome docking.

Christoforidis S, McBride HM, Burgoyne RD, Zerial M.

Nature. 1999 Feb 18;397(6720):621-5.

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