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Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice.

Nagasu H, Satoh M, Kiyokage E, Kidokoro K, Toida K, Channon KM, Kanwar YS, Sasaki T, Kashihara N.

Lab Invest. 2016 Jan;96(1):25-36. doi: 10.1038/labinvest.2015.128. Epub 2015 Nov 9.


Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-β1-induced kidney injury in a mouse model of diabetes.

Lo CS, Shi Y, Chang SY, Abdo S, Chenier I, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

Diabetologia. 2015 Oct;58(10):2443-54. doi: 10.1007/s00125-015-3700-y. Epub 2015 Aug 1.


Enhancing eNOS activity with simultaneous inhibition of IKKβ restores vascular function in Ins2(Akita+/-) type-1 diabetic mice.

Krishnan M, Janardhanan P, Roman L, Reddick RL, Natarajan M, van Haperen R, Habib SL, de Crom R, Mohan S.

Lab Invest. 2015 Oct;95(10):1092-104. doi: 10.1038/labinvest.2015.96. Epub 2015 Jul 27.


Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney.

Okamoto K, Honda K, Doi K, Ishizu T, Katagiri D, Wada T, Tomita K, Ohtake T, Kaneko T, Kobayashi S, Nangaku M, Tokunaga K, Noiri E.

Am J Pathol. 2015 Jul;185(7):1889-98. doi: 10.1016/j.ajpath.2015.03.025. Epub 2015 May 15.


The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice.

Xu C, Zhu L, Chan T, Lu X, Shen W, Gillies MC, Zhou F.

PLoS One. 2015 Mar 19;10(3):e0120760. doi: 10.1371/journal.pone.0120760. eCollection 2015.


In vivo ZW800-microbead imaging of retinal and choroidal vascular leakage in mice.

Gupta I, Cahoon J, Zhang X, Jones AD, Ahmed F, Uehara H, Messenger W, Ambati BK.

Exp Eye Res. 2015 May;134:155-8. doi: 10.1016/j.exer.2014.12.013. Epub 2014 Dec 20.


Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.

Wu X, Davis RC, McMillen TS, Schaeffer V, Zhou Z, Qi H, Mazandarani PN, Alialy R, Hudkins KL, Lusis AJ, LeBoeuf RC.

Physiol Rep. 2014 Nov 26;2(11). pii: e12208. doi: 10.14814/phy2.12208. Print 2014 Nov 1.


DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.

Soto I, Howell GR, John CW, Kief JL, Libby RT, John SW.

PLoS One. 2014 Sep 10;9(9):e107291. doi: 10.1371/journal.pone.0107291. eCollection 2014.


Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse.

Hombrebueno JR, Chen M, Penalva RG, Xu H.

PLoS One. 2014 May 21;9(5):e97970. doi: 10.1371/journal.pone.0097970. eCollection 2014.


Molecular analysis of blood-retinal barrier loss in the Akimba mouse, a model of advanced diabetic retinopathy.

Wisniewska-Kruk J, Klaassen I, Vogels IM, Magno AL, Lai CM, Van Noorden CJ, Schlingemann RO, Rakoczy EP.

Exp Eye Res. 2014 May;122:123-31. doi: 10.1016/j.exer.2014.03.005. Epub 2014 Apr 3.


Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.

Wang L, Tang Y, Eisner W, Sparks MA, Buckley AF, Spurney RF.

Biochem Biophys Res Commun. 2014 Feb 21;444(4):622-7. doi: 10.1016/j.bbrc.2014.01.115. Epub 2014 Jan 31.


Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling.

McBride JD, Jenkins AJ, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin CT, Aston CE, Lyons TJ, Tomasek JJ, Ma JX.

J Invest Dermatol. 2014 Jun;134(6):1725-34. doi: 10.1038/jid.2014.40. Epub 2014 Jan 24.


Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice.

Salem ES, Grobe N, Elased KM.

Am J Physiol Renal Physiol. 2014 Mar 15;306(6):F629-39. doi: 10.1152/ajprenal.00516.2013. Epub 2014 Jan 22.


Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus.

Guo C, Zhang Z, Zhang P, Makita J, Kawada H, Blessing K, Kador PF.

Exp Eye Res. 2014 Feb;119:77-87. doi: 10.1016/j.exer.2013.12.009. Epub 2013 Dec 25.


SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.

Vallon V, Gerasimova M, Rose MA, Masuda T, Satriano J, Mayoux E, Koepsell H, Thomson SC, Rieg T.

Am J Physiol Renal Physiol. 2014 Jan;306(2):F194-204. doi: 10.1152/ajprenal.00520.2013. Epub 2013 Nov 13.


Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin.

Rajab M, Jin H, Welzig CM, Albano A, Aronovitz M, Zhang Y, Park HJ, Link MS, Noujaim SF, Galper JB.

Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1807-16. doi: 10.1152/ajpheart.00979.2012. Epub 2013 Oct 25.


Impaired macrophage and satellite cell infiltration occurs in a muscle-specific fashion following injury in diabetic skeletal muscle.

Krause MP, Al-Sajee D, D'Souza DM, Rebalka IA, Moradi J, Riddell MC, Hawke TJ.

PLoS One. 2013 Aug 12;8(8):e70971. doi: 10.1371/journal.pone.0070971. eCollection 2013.


Age-dependent labeling and imaging of insulin secretory granules.

Ivanova A, Kalaidzidis Y, Dirkx R, Sarov M, Gerlach M, Schroth-Diez B, Müller A, Liu Y, Andree C, Mulligan B, Münster C, Kurth T, Bickle M, Speier S, Anastassiadis K, Solimena M.

Diabetes. 2013 Nov;62(11):3687-96. doi: 10.2337/db12-1819. Epub 2013 Aug 8.


Protection against type 1 diabetes upon Coxsackievirus B4 infection and iNKT-cell stimulation: role of suppressive macrophages.

Ghazarian L, Diana J, Beaudoin L, Larsson PG, Puri RK, van Rooijen N, Flodström-Tullberg M, Lehuen A.

Diabetes. 2013 Nov;62(11):3785-96. doi: 10.2337/db12-0958. Epub 2013 Jul 26.

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