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Items: 1 to 20 of 330


Study on the active mechanism of β-secretase inhibitors by molecular simulations.

Tian YL, Lv M, Li JJ, Xu T, Zhai HL, Zhang XY.

Eur J Pharm Sci. 2015 Aug 30;76:138-48. doi: 10.1016/j.ejps.2015.05.007. Epub 2015 May 9.


Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain.

Xue ZQ, He ZW, Yu JJ, Cai Y, Qiu WY, Pan A, Gai WP, Cai H, Luo XG, Ma C, Yan XX.

BMC Neurol. 2015 May 2;15:71. doi: 10.1186/s12883-015-0327-z.


Haloperidol inhibits Memapsin 2: innovation by docking simulation and in vitro assay.

Al-Nadaf AH, Taha MO, Aldal'in HK.

Pak J Pharm Sci. 2015 Jan;28(1):139-46.


The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex.

Hettich MM, Matthes F, Ryan DP, Griesche N, Schröder S, Dorn S, Krauβ S, Ehninger D.

PLoS One. 2014 Jul 15;9(7):e102420. doi: 10.1371/journal.pone.0102420. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e107080.


Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.

Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF.

J Neurochem. 2014 Jul;130(1):4-28. doi: 10.1111/jnc.12715. Epub 2014 Apr 19. Review.


Targeting the β secretase BACE1 for Alzheimer's disease therapy.

Yan R, Vassar R.

Lancet Neurol. 2014 Mar;13(3):319-29. doi: 10.1016/S1474-4422(13)70276-X. Epub 2014 Feb 17. Review.


High activities of BACE1 in brains with mild cognitive impairment.

Cheng X, He P, Lee T, Yao H, Li R, Shen Y.

Am J Pathol. 2014 Jan;184(1):141-7. doi: 10.1016/j.ajpath.2013.10.002.


Can BACE1 inhibition mitigate early axonal pathology in neurological diseases?

Yan XX, Ma C, Gai WP, Cai H, Luo XG.

J Alzheimers Dis. 2014;38(4):705-18. doi: 10.3233/JAD-131400. Review.


The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.

Kandalepas PC, Sadleir KR, Eimer WA, Zhao J, Nicholson DA, Vassar R.

Acta Neuropathol. 2013 Sep;126(3):329-52. doi: 10.1007/s00401-013-1152-3. Epub 2013 Jul 3. Erratum in: Acta Neuropathol. 2013 Oct;126(4):623.


Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors.

Zou Y, Li L, Chen W, Chen T, Ma L, Wang X, Xiong B, Xu Y, Shen J.

Molecules. 2013 May 16;18(5):5706-22. doi: 10.3390/molecules18055706.


Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease.

Li X, Hong L, Coughlan K, Wang L, Cao L, Tang J.

Acta Biochim Biophys Sin (Shanghai). 2013 Aug;45(8):613-21. doi: 10.1093/abbs/gmt050. Epub 2013 May 15. Review.


Inhibitory evaluation of sulfonamide chalcones on β-secretase and acylcholinesterase.

Kang JE, Cho JK, Curtis-Long MJ, Ryu HW, Kim JH, Kim HJ, Yuk HJ, Kim DW, Park KH.

Molecules. 2012 Dec 21;18(1):140-53. doi: 10.3390/molecules18010140.


Transcriptional and post-transcriptional regulation of β-secretase.

Tamagno E, Guglielmotto M, Monteleone D, Vercelli A, Tabaton M.

IUBMB Life. 2012 Dec;64(12):943-50. doi: 10.1002/iub.1099. Review.


Splice variants of the Alzheimer's disease beta-secretase, BACE1.

Holsinger RM, Goense N, Bohorquez J, Strappe P.

Neurogenetics. 2013 Feb;14(1):1-9. doi: 10.1007/s10048-012-0348-3. Epub 2012 Nov 11. Review.


β-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau.

Tsolakidou A, Alexopoulos P, Guo LH, Grimmer T, Westerteicher C, Kratzer M, Jiang M, Bujo H, Roselli F, Leante MR, Livrea P, Kurz A, Perneczky R.

Alzheimers Dement. 2013 Jul;9(4):386-91. doi: 10.1016/j.jalz.2012.01.015. Epub 2012 Nov 3.


BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus.

Kang EL, Biscaro B, Piazza F, Tesco G.

J Biol Chem. 2012 Dec 14;287(51):42867-80. doi: 10.1074/jbc.M112.407072. Epub 2012 Oct 29.


Development and characterization of a novel membrane assay for full-length BACE-1 at pH 6.0.

Saric A, Brügge Lz, Müller-Pompalla D, Rysiok T, Ousson S, Permanne B, Quattropani A, Busch M, Beher D, Hussain I.

J Biomol Screen. 2013 Mar;18(3):277-85. doi: 10.1177/1087057112462237. Epub 2012 Sep 27.


A common BACE1 polymorphism is a risk factor for sporadic Creutzfeldt-Jakob disease.

Calero O, Bullido MJ, Clarimón J, Frank-García A, Martínez-Martín P, Lleó A, Rey MJ, Sastre I, Rábano A, de Pedro-Cuesta J, Ferrer I, Calero M.

PLoS One. 2012;7(8):e43926. doi: 10.1371/journal.pone.0043926. Epub 2012 Aug 30.


Can platelet BACE1 levels be used as a biomarker for Alzheimer's disease? Proof-of-concept study.

Decourt B, Walker A, Gonzales A, Malek-Ahmadi M, Liesback C, Davis KJ, Belden CM, Jacobson SA, Sabbagh MN.

Platelets. 2013;24(3):235-8. doi: 10.3109/09537104.2012.688899. Epub 2012 Jul 9.


A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing.

Fisette JF, Montagna DR, Mihailescu MR, Wolfe MS.

J Neurochem. 2012 Jun;121(5):763-73. doi: 10.1111/j.1471-4159.2012.07680.x. Epub 2012 Mar 13.

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