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Links from Protein

Items: 1 to 20 of 183

1.

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.

Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. doi: 10.1073/pnas.1415365112. Epub 2014 Dec 17.

2.

Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.

Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M.

Cancer Res. 2014 Dec 15;74(24):7418-29. doi: 10.1158/0008-5472.CAN-14-1420. Epub 2014 Sep 30.

3.

Immunohistochemical analysis of PDK1 expression in breast cancer.

Arsenic R.

Diagn Pathol. 2014 Apr 16;9:82. doi: 10.1186/1746-1596-9-82.

4.

Silencing of PDK1 gene expression by RNA interference suppresses growth of esophageal cancer.

Yu J, Chen KS, Li YN, Yang J, Zhao L.

Asian Pac J Cancer Prev. 2012;13(8):4147-51.

5.

3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.

Gagliardi PA, di Blasio L, Orso F, Seano G, Sessa R, Taverna D, Bussolino F, Primo L.

Neoplasia. 2012 Aug;14(8):719-31.

6.

PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia.

Mashukova A, Forteza R, Wald FA, Salas PJ.

Mol Biol Cell. 2012 May;23(9):1664-74. doi: 10.1091/mbc.E11-12-0988. Epub 2012 Mar 7.

7.

[Inhibition of PDK1 gene expression in esophageal cancer EC9706 cells by RNA interference and its effect on their malignant biological behavior].

Yu J, Chen KS, Li YN, Yang J, Zhao L.

Zhonghua Zhong Liu Za Zhi. 2011 Jun;33(6):410-4. Chinese.

PMID:
21875479
8.

Targeting PDK1 in cancer.

Raimondi C, Falasca M.

Curr Med Chem. 2011;18(18):2763-9. Review.

PMID:
21568903
9.

Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.

Nagashima K, Shumway SD, Sathyanarayanan S, Chen AH, Dolinski B, Xu Y, Keilhack H, Nguyen T, Wiznerowicz M, Li L, Lutterbach BA, Chi A, Paweletz C, Allison T, Yan Y, Munshi SK, Klippel A, Kraus M, Bobkova EV, Deshmukh S, Xu Z, Mueller U, Szewczak AA, Pan BS, Richon V, Pollock R, Blume-Jensen P, Northrup A, Andersen JN.

J Biol Chem. 2011 Feb 25;286(8):6433-48. doi: 10.1074/jbc.M110.156463. Epub 2010 Nov 30.

10.

Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening.

Bobkova EV, Weber MJ, Xu Z, Zhang YL, Jung J, Blume-Jensen P, Northrup A, Kunapuli P, Andersen JN, Kariv I.

J Biol Chem. 2010 Jun 11;285(24):18838-46. doi: 10.1074/jbc.M109.089946. Epub 2010 Apr 12.

11.

3-phosphoinositide-dependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway.

Lu Z, Cox-Hipkin MA, Windsor WT, Boyapati A.

Mol Cancer Res. 2010 Mar;8(3):421-32. doi: 10.1158/1541-7786.MCR-09-0179. Epub 2010 Mar 2.

12.

3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.

Maurer M, Su T, Saal LH, Koujak S, Hopkins BD, Barkley CR, Wu J, Nandula S, Dutta B, Xie Y, Chin YR, Kim DI, Ferris JS, Gruvberger-Saal SK, Laakso M, Wang X, Memeo L, Rojtman A, Matos T, Yu JS, Cordon-Cardo C, Isola J, Terry MB, Toker A, Mills GB, Zhao JJ, Murty VV, Hibshoosh H, Parsons R.

Cancer Res. 2009 Aug 1;69(15):6299-306. doi: 10.1158/0008-5472.CAN-09-0820. Epub 2009 Jul 14.

13.

PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound.

Cen L, Hsieh FC, Lin HJ, Chen CS, Qualman SJ, Lin J.

Br J Cancer. 2007 Sep 17;97(6):785-91.

14.

Steady-state kinetic mechanism of PDK1.

Gao X, Harris TK.

J Biol Chem. 2006 Aug 4;281(31):21670-81. Epub 2006 May 31.

15.

Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation".

Gruber T, Freeley M, Thuille N, Heit I, Shaw S, Long A, Baier G.

Science. 2006 Apr 7;312(5770):55; author reply 55.

16.

Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer.

Lin HJ, Hsieh FC, Song H, Lin J.

Br J Cancer. 2005 Dec 12;93(12):1372-81.

17.

Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.

Scheid MP, Parsons M, Woodgett JR.

Mol Cell Biol. 2005 Mar;25(6):2347-63.

18.

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

Komander D, Kular G, Deak M, Alessi DR, van Aalten DM.

J Biol Chem. 2005 May 13;280(19):18797-802. Epub 2005 Mar 1.

19.

PDK1, the master regulator of AGC kinase signal transduction.

Mora A, Komander D, van Aalten DM, Alessi DR.

Semin Cell Dev Biol. 2004 Apr;15(2):161-70. Review.

PMID:
15209375
20.

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.

Frödin M, Antal TL, Dümmler BA, Jensen CJ, Deak M, Gammeltoft S, Biondi RM.

EMBO J. 2002 Oct 15;21(20):5396-407.

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