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Items: 17


Gated regulation of CRAC channel ion selectivity by STIM1.

McNally BA, Somasundaram A, Yamashita M, Prakriya M.

Nature. 2012 Jan 25;482(7384):241-5. doi: 10.1038/nature10752.


The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels.

Wang Y, Deng X, Mancarella S, Hendron E, Eguchi S, Soboloff J, Tang XD, Gill DL.

Science. 2010 Oct 1;330(6000):105-9. doi: 10.1126/science.1191086.


Store-independent activation of Orai1 by SPCA2 in mammary tumors.

Feng M, Grice DM, Faddy HM, Nguyen N, Leitch S, Wang Y, Muend S, Kenny PA, Sukumar S, Roberts-Thomson SJ, Monteith GR, Rao R.

Cell. 2010 Oct 1;143(1):84-98. doi: 10.1016/j.cell.2010.08.040.


A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells.

Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y.

Nat Cell Biol. 2010 May;12(5):436-46. doi: 10.1038/ncb2045. Epub 2010 Apr 25.


A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry.

Liao Y, Plummer NW, George MD, Abramowitz J, Zhu MX, Birnbaumer L.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3202-6. doi: 10.1073/pnas.0813346106. Epub 2009 Feb 12.


SOAR and the polybasic STIM1 domains gate and regulate Orai channels.

Yuan JP, Zeng W, Dorwart MR, Choi YJ, Worley PF, Muallem S.

Nat Cell Biol. 2009 Mar;11(3):337-43. doi: 10.1038/ncb1842. Epub 2009 Feb 1.


R93W mutation in Orai1 causes impaired calcium influx in platelets.

Bergmeier W, Oh-Hora M, McCarl CA, Roden RC, Bray PF, Feske S.

Blood. 2009 Jan 15;113(3):675-8. doi: 10.1182/blood-2008-08-174516. Epub 2008 Oct 24.


Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation.

Luik RM, Wang B, Prakriya M, Wu MM, Lewis RS.

Nature. 2008 Jul 24;454(7203):538-42. doi: 10.1038/nature07065. Epub 2008 Jul 2.


Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

Lioudyno MI, Kozak JA, Penna A, Safrina O, Zhang SL, Sen D, Roos J, Stauderman KA, Cahalan MD.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2011-6. doi: 10.1073/pnas.0706122105. Epub 2008 Feb 4.


Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

Muik M, Frischauf I, Derler I, Fahrner M, Bergsmann J, Eder P, Schindl R, Hesch C, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C.

J Biol Chem. 2008 Mar 21;283(12):8014-22. doi: 10.1074/jbc.M708898200. Epub 2008 Jan 10.


Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai.

Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD.

Nature. 2006 Sep 14;443(7108):226-9. Epub 2006 Aug 20.


Orai1 is an essential pore subunit of the CRAC channel.

Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG.

Nature. 2006 Sep 14;443(7108):230-3. Epub 2006 Aug 20.


Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1.

Mercer JC, Dehaven WI, Smyth JT, Wedel B, Boyles RR, Bird GS, Putney JW Jr.

J Biol Chem. 2006 Aug 25;281(34):24979-90. Epub 2006 Jun 28.


Orai1 and STIM reconstitute store-operated calcium channel function.

Soboloff J, Spassova MA, Tang XD, Hewavitharana T, Xu W, Gill DL.

J Biol Chem. 2006 Jul 28;281(30):20661-5. Epub 2006 Jun 9.


CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.

Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP.

Science. 2006 May 26;312(5777):1220-3. Epub 2006 Apr 27.


A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.

Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A.

Nature. 2006 May 11;441(7090):179-85. Epub 2006 Apr 2.


Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings.

Feske S, Müller JM, Graf D, Kroczek RA, Dräger R, Niemeyer C, Baeuerle PA, Peter HH, Schlesier M.

Eur J Immunol. 1996 Sep;26(9):2119-26.

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