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Items: 1 to 20 of 137


Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure.

Yang KC, Jay PY, McMullen JR, Nerbonne JM.

Cardiovasc Res. 2012 Feb 1;93(2):252-62. doi: 10.1093/cvr/cvr283. Epub 2011 Oct 27.


Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy.

Yang KC, Foeger NC, Marionneau C, Jay PY, McMullen JR, Nerbonne JM.

J Physiol. 2010 Dec 15;588(Pt 24):5015-32. doi: 10.1113/jphysiol.2010.197418. Epub 2010 Oct 25.


Exercise training and PI3Kα-induced electrical remodeling is independent of cellular hypertrophy and Akt signaling.

Yang KC, Tseng YT, Nerbonne JM.

J Mol Cell Cardiol. 2012 Oct;53(4):532-41. doi: 10.1016/j.yjmcc.2012.07.004. Epub 2012 Jul 21.


Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.

Hofmann F, Fabritz L, Stieber J, Schmitt J, Kirchhof P, Ludwig A, Herrmann S.

Cardiovasc Res. 2012 Aug 1;95(3):317-26. doi: 10.1093/cvr/cvs184. Epub 2012 May 31.


Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy.

Marionneau C, Brunet S, Flagg TP, Pilgram TK, Demolombe S, Nerbonne JM.

Circ Res. 2008 Jun 6;102(11):1406-15. doi: 10.1161/CIRCRESAHA.107.170050. Epub 2008 May 1.


Temporal alterations and cellular mechanisms of transmural repolarization during progression of mouse cardiac hypertrophy and failure.

Shi C, Wang X, Dong F, Wang Y, Hui J, Lin Z, Yang J, Xu Y.

Acta Physiol (Oxf). 2013 May;208(1):95-110. doi: 10.1111/apha.12071. Epub 2013 Mar 11.


Electrical remodeling in a transgenic mouse model of alpha1B-adrenergic receptor overexpression.

Rivard K, Trépanier-Boulay V, Rindt H, Fiset C.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H704-18. doi: 10.1152/ajpheart.00337.2008. Epub 2008 Dec 26.


Cardiac-specific overexpression of the human type 1 angiotensin II receptor causes delayed repolarization.

Rivard K, Paradis P, Nemer M, Fiset C.

Cardiovasc Res. 2008 Apr 1;78(1):53-62. doi: 10.1093/cvr/cvn020. Epub 2008 Jan 31.


Selective activation of PI3Kalpha/Akt/GSK-3beta signalling and cardiac compensatory hypertrophy during recovery from heart failure.

Braz JC, Gill RM, Corbly AK, Jones BD, Jin N, Vlahos CJ, Wu Q, Shen W.

Eur J Heart Fail. 2009 Aug;11(8):739-48. doi: 10.1093/eurjhf/hfp094.


Simulation study of cellular electric properties in heart failure.

Priebe L, Beuckelmann DJ.

Circ Res. 1998 Jun 15;82(11):1206-23.


Physiological remodelling of potassium channels in the heart.

Rozanski GJ.

Cardiovasc Res. 2012 Feb 1;93(2):218-9. doi: 10.1093/cvr/cvr340. Epub 2011 Dec 14. No abstract available.


Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis.

Michael G, Xiao L, Qi XY, Dobrev D, Nattel S.

Cardiovasc Res. 2009 Feb 15;81(3):491-9. doi: 10.1093/cvr/cvn266. Epub 2008 Sep 30. Review.


Attenuation of I(K,slow1) and I(K,slow2) in Kv1/Kv2DN mice prolongs APD and QT intervals but does not suppress spontaneous or inducible arrhythmias.

Kodirov SA, Brunner M, Nerbonne JM, Buckett P, Mitchell GF, Koren G.

Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H368-74.


The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization.

Lopez-Izquierdo A, Pereira RO, Wende AR, Punske BB, Abel ED, Tristani-Firouzi M.

Am J Physiol Heart Circ Physiol. 2014 Mar 1;306(5):H747-54. doi: 10.1152/ajpheart.00849.2013. Epub 2013 Dec 27.


Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure.

Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K.

Cardiovasc Res. 2014 Oct 1;104(1):183-93. doi: 10.1093/cvr/cvu185. Epub 2014 Aug 5.


Chronic doxycycline exposure accelerates left ventricular hypertrophy and progression to heart failure in mice after thoracic aorta constriction.

Vinet L, Rouet-Benzineb P, Marniquet X, Pellegrin N, Mangin L, Louedec L, Samuel JL, Mercadier JJ.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H352-60. doi: 10.1152/ajpheart.01101.2007. Epub 2008 May 16.


Early ion-channel remodeling and arrhythmias precede hypertrophy in a mouse model of complete atrioventricular block.

Bignolais O, Quang KL, Naud P, El Harchi A, Briec F, Piron J, Bourge A, Leoni AL, Charpentier F, Demolombe S.

J Mol Cell Cardiol. 2011 Nov;51(5):713-21. doi: 10.1016/j.yjmcc.2011.07.008. Epub 2011 Jul 20.


Overexpression of nerve growth factor in the heart alters ion channel activity and beta-adrenergic signalling in an adult transgenic mouse.

Heath BM, Xia J, Dong E, An RH, Brooks A, Liang C, Federoff HJ, Kass RS.

J Physiol. 1998 Nov 1;512 ( Pt 3):779-91.


Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy.

Yasuno S, Kuwahara K, Kinoshita H, Yamada C, Nakagawa Y, Usami S, Kuwabara Y, Ueshima K, Harada M, Nishikimi T, Nakao K.

Br J Pharmacol. 2013 Dec;170(7):1384-95. doi: 10.1111/bph.12328.

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