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Results: 1 to 20 of 102

1.

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.

MacKenzie KF, Wallace DA, Hill EV, Anthony DF, Henderson DJ, Houslay DM, Arthur JS, Baillie GS, Houslay MD.

Biochem J. 2011 May 1;435(3):755-69. doi: 10.1042/BJ20101184.

PMID:
21323643
[PubMed - indexed for MEDLINE]
Free Article
2.

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA).

Collins DM, Murdoch H, Dunlop AJ, Charych E, Baillie GS, Wang Q, Herberg FW, Brandon N, Prinz A, Houslay MD.

Cell Signal. 2008 Dec;20(12):2356-69. doi: 10.1016/j.cellsig.2008.09.017. Epub 2008 Oct 2.

PMID:
18845247
[PubMed - indexed for MEDLINE]
3.

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.

Li X, Vadrevu S, Dunlop A, Day J, Advant N, Troeger J, Klussmann E, Jaffrey E, Hay RT, Adams DR, Houslay MD, Baillie GS.

Biochem J. 2010 Apr 28;428(1):55-65. doi: 10.1042/BJ20091672.

PMID:
20196770
[PubMed - indexed for MEDLINE]
Free Article
4.

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).

MacKenzie SJ, Baillie GS, McPhee I, MacKenzie C, Seamons R, McSorley T, Millen J, Beard MB, van Heeke G, Houslay MD.

Br J Pharmacol. 2002 Jun;136(3):421-33.

PMID:
12023945
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579.

Hill EV, Sheppard CL, Cheung YF, Gall I, Krause E, Houslay MD.

Cell Signal. 2006 Nov;18(11):2056-69. Epub 2006 Aug 1.

PMID:
16973330
[PubMed - indexed for MEDLINE]
6.

Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.

Bolger GB, Peden AH, Steele MR, MacKenzie C, McEwan DG, Wallace DA, Huston E, Baillie GS, Houslay MD.

J Biol Chem. 2003 Aug 29;278(35):33351-63. Epub 2003 Jun 16.

PMID:
12810716
[PubMed - indexed for MEDLINE]
Free Article
7.

The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways.

Houslay MD, Baillie GS.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1186-90. Review.

PMID:
14641023
[PubMed - indexed for MEDLINE]
8.

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.

Murdoch H, Mackie S, Collins DM, Hill EV, Bolger GB, Klussmann E, Porteous DJ, Millar JK, Houslay MD.

J Neurosci. 2007 Aug 29;27(35):9513-24.

PMID:
17728464
[PubMed - indexed for MEDLINE]
Free Article
10.

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting.

Beard MB, Huston E, Campbell L, Gall I, McPhee I, Yarwood S, Scotland G, Houslay MD.

Cell Signal. 2002 May;14(5):453-65.

PMID:
11882390
[PubMed - indexed for MEDLINE]
11.

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.

McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD.

Cell Signal. 2005 Sep;17(9):1158-73.

PMID:
15905070
[PubMed - indexed for MEDLINE]
12.

Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNF╬▒ production.

Menon MB, Tiedje C, Lafera J, Ronkina N, Konen T, Kotlyarov A, Gaestel M.

Biochem J. 2013 Dec 1;456(2):163-72. doi: 10.1042/BJ20130755. Erratum in: Biochem J. 2014 Jan 1;457(1):229.

PMID:
24020373
[PubMed - indexed for MEDLINE]
Free Article
13.

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.

Houslay MD, Adams DR.

Biochem J. 2003 Feb 15;370(Pt 1):1-18. Review.

PMID:
12444918
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.

Wallace DA, Johnston LA, Huston E, MacMaster D, Houslay TM, Cheung YF, Campbell L, Millen JE, Smith RA, Gall I, Knowles RG, Sullivan M, Houslay MD.

Mol Pharmacol. 2005 Jun;67(6):1920-34. Epub 2005 Feb 28.

PMID:
15738310
[PubMed - indexed for MEDLINE]
Free Article
16.

Mitogen-activated protein kinase-activated protein kinase 2 (MK2) contributes to secondary damage after spinal cord injury.

Ghasemlou N, Lopez-Vales R, Lachance C, Thuraisingam T, Gaestel M, Radzioch D, David S.

J Neurosci. 2010 Oct 13;30(41):13750-9. doi: 10.1523/JNEUROSCI.2998-10.2010.

PMID:
20943915
[PubMed - indexed for MEDLINE]
Free Article
17.

Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5.

Gerits N, Mikalsen T, Kostenko S, Shiryaev A, Johannessen M, Moens U.

J Biol Chem. 2007 Dec 21;282(51):37232-43. Epub 2007 Oct 17.

PMID:
17947239
[PubMed - indexed for MEDLINE]
Free Article
18.

MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia.

Gorog DA, Jabr RI, Tanno M, Sarafraz N, Clark JE, Fisher SG, Cao XB, Bellahcene M, Dighe K, Kabir AM, Quinlan RA, Kato K, Gaestel M, Marber MS, Heads RJ.

Cell Stress Chaperones. 2009 Sep;14(5):477-89. doi: 10.1007/s12192-009-0101-5. Epub 2009 Feb 13.

PMID:
19214782
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.

Bolger GB, Baillie GS, Li X, Lynch MJ, Herzyk P, Mohamed A, Mitchell LH, McCahill A, Hundsrucker C, Klussmann E, Adams DR, Houslay MD.

Biochem J. 2006 Aug 15;398(1):23-36.

PMID:
16689683
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner.

Rolli M, Kotlyarov A, Sakamoto KM, Gaestel M, Neininger A.

J Biol Chem. 1999 Jul 9;274(28):19559-64.

PMID:
10391889
[PubMed - indexed for MEDLINE]
Free Article

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