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Results: 1 to 20 of 119

1.

Safety and immunogenicity observations pooled from eight clinical trials of recombinant human thrombin.

Ballard JL, Weaver FA, Singla NK, Chapman WC, Alexander WA.

J Am Coll Surg. 2010 Feb;210(2):199-204. doi: 10.1016/j.jamcollsurg.2009.09.042. Epub 2009 Dec 14.

PMID:
20113940
[PubMed - indexed for MEDLINE]
2.

Immunogenicity and safety of re-exposure to recombinant human thrombin in surgical hemostasis.

Singla NK, Gasparis AP, Ballard JL, Baron JM, Butine MD, Pribble JP, Alexander WA; RECOTHROM Re-Exposure Study Group.

J Am Coll Surg. 2011 Dec;213(6):722-7. doi: 10.1016/j.jamcollsurg.2011.08.019. Epub 2011 Sep 29.

PMID:
21958507
[PubMed - indexed for MEDLINE]
3.

Safety and immunogenicity of recombinant human thrombin: a pooled analysis of results from 10 clinical trials.

Singla NK, Foster KN, Alexander WA, Pribble JP.

Pharmacotherapy. 2012 Nov;32(11):998-1005. doi: 10.1002/phar.1128. Epub 2012 Oct 26.

PMID:
23108631
[PubMed - indexed for MEDLINE]
4.

A phase 3b, open-label, single-group immunogenicity and safety study of topical recombinant thrombin in surgical hemostasis.

Singla NK, Ballard JL, Moneta G, Randleman CD Jr, Renkens KL, Alexander WA.

J Am Coll Surg. 2009 Jul;209(1):68-74. doi: 10.1016/j.jamcollsurg.2009.03.016. Epub 2009 May 28.

PMID:
19651065
[PubMed - indexed for MEDLINE]
5.

Recombinant thrombin: safety and immunogenicity in burn wound excision and grafting.

Greenhalgh DG, Gamelli RL, Collins J, Sood R, Mozingo DW, Gray TE, Alexander WA.

J Burn Care Res. 2009 May-Jun;30(3):371-9. doi: 10.1097/BCR.0b013e3181a28979.

PMID:
19349898
[PubMed - indexed for MEDLINE]
6.

Recombinant human thrombin: safety and immunogenicity in pediatric burn wound excision.

Foster KN, Mullins RF, Greenhalgh DG, Gamelli RL, Glat P, Lentz CW, Kahn SA, Brandigi C, Fredlund P, Alexander WA.

J Pediatr Surg. 2011 Oct;46(10):1992-9. doi: 10.1016/j.jpedsurg.2011.05.022.

PMID:
22008340
[PubMed - indexed for MEDLINE]
7.

A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.

Weaver FA, Lew W, Granke K, Yonehiro L, Delange B, Alexander WA; Study Investigators.

J Vasc Surg. 2008 Jun;47(6):1266-73. doi: 10.1016/j.jvs.2008.01.034. Epub 2008 Apr 28.

PMID:
18440754
[PubMed - indexed for MEDLINE]
Free Article
8.

A safety review of topical bovine thrombin-induced generation of antibodies to bovine proteins.

Ofosu FA, Crean S, Reynolds MW.

Clin Ther. 2009 Apr;31(4):679-91. doi: 10.1016/j.clinthera.2009.04.021. Review.

PMID:
19446142
[PubMed - indexed for MEDLINE]
9.

A phase 3, randomized, double-blind comparative study of the efficacy and safety of topical recombinant human thrombin and bovine thrombin in surgical hemostasis.

Chapman WC, Singla N, Genyk Y, McNeil JW, Renkens KL Jr, Reynolds TC, Murphy A, Weaver FA.

J Am Coll Surg. 2007 Aug;205(2):256-65. Epub 2007 Jun 27.

PMID:
17660072
[PubMed - indexed for MEDLINE]
10.

A review of three stand-alone topical thrombins for surgical hemostasis.

Cheng CM, Meyer-Massetti C, Kayser SR.

Clin Ther. 2009 Jan;31(1):32-41. doi: 10.1016/j.clinthera.2009.01.005. Review.

PMID:
19243705
[PubMed - indexed for MEDLINE]
11.

Persistence of antibodies to the topical hemostat bovine thrombin.

Randleman CD Jr, Singla NK, Renkens KL, Souza S, Pribble JP, Alexander WA.

J Am Coll Surg. 2010 Dec;211(6):798-803. doi: 10.1016/j.jamcollsurg.2010.07.023. Epub 2010 Oct 25.

PMID:
20980172
[PubMed - indexed for MEDLINE]
12.

Preclinical safety of recombinant human thrombin.

Heffernan JK, Ponce RA, Zuckerman LA, Volpone JP, Visich J, Giste EE, Jenkins N, Boster D, Pederson S, Knitter G, Palmer T, Wills M, Early RJ, Rogge MC.

Regul Toxicol Pharmacol. 2007 Feb;47(1):48-58. Epub 2006 Sep 12.

PMID:
16971028
[PubMed - indexed for MEDLINE]
13.

Topical recombinant human thrombin in surgical hemostasis.

Bowman LJ, Anderson CD, Chapman WC.

Semin Thromb Hemost. 2010 Jul;36(5):477-84. doi: 10.1055/s-0030-1255441. Epub 2010 Jul 14. Review.

PMID:
20632245
[PubMed - indexed for MEDLINE]
14.

Perioperative topical bovine thrombin exposure is not associated with hemodialysis graft thrombosis.

Vannorsdall MD, Arkel YS, Ku DH, Lucas FL, Himmelfarb J.

Kidney Int. 2003 Aug;64(2):690-6.

PMID:
12846767
[PubMed - indexed for MEDLINE]
15.

Topical bovine thrombin and adverse events: a review of the literature.

Clark J, Crean S, Reynolds MW.

Curr Med Res Opin. 2008 Jul;24(7):2071-87. doi: 10.1185/03007990802186417 . Epub 2008 Jun 11. Review.

PMID:
18549663
[PubMed - indexed for MEDLINE]
16.

Phase 3, randomized, double-blind study of plasma-derived human thrombin versus bovine thrombin in achieving hemostasis in patients undergoing surgery.

Doria C, Fischer CP, Wood CG, Li PM, Marra S, Hart J.

Curr Med Res Opin. 2008 Mar;24(3):785-94. doi: 10.1185/030079908X273426. Epub 2008 Jan 31.

PMID:
18241525
[PubMed - indexed for MEDLINE]
17.

Topical use of recombinant human thrombin for operative hemostasis.

Anderson CD, Bowman LJ, Chapman WC.

Expert Opin Biol Ther. 2009 Jan;9(1):133-7. doi: 10.1517/14712590802588773 . Review.

PMID:
19063699
[PubMed - indexed for MEDLINE]
18.

Recombinant human thrombin: in surgical hemostasis.

Croxtall JD, Scott LJ.

BioDrugs. 2009;23(5):333-8. doi: 10.2165/11202650-000000000-00000. Review.

PMID:
19754221
[PubMed - indexed for MEDLINE]
19.

Immune-mediated coagulopathy: a case report.

Naoum JJ.

Pharmacotherapy. 2009 Jul;29(7 Pt 2):13S-7S. doi: 10.1592/phco.29.pt2.13S.

PMID:
19558280
[PubMed - indexed for MEDLINE]
20.

Immunologic impact and clinical outcomes after surgical exposure to bovine thrombin.

Ortel TL, Mercer MC, Thames EH, Moore KD, Lawson JH.

Ann Surg. 2001 Jan;233(1):88-96.

PMID:
11141230
[PubMed - indexed for MEDLINE]
Free PMC Article

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