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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis.

Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M.

Nature. 2009 Jan 1;457(7225):102-6. doi: 10.1038/nature07623.


Cancer: Inflaming metastasis.

Mantovani A.

Nature. 2009 Jan 1;457(7225):36-7. doi: 10.1038/457036b. No abstract available.


Tumor-produced versican V1 enhances hCAP18/LL-37 expression in macrophages through activation of TLR2 and vitamin D3 signaling to promote ovarian cancer progression in vitro.

Li D, Wang X, Wu JL, Quan WQ, Ma L, Yang F, Wu KY, Wan HY.

PLoS One. 2013;8(2):e56616. doi: 10.1371/journal.pone.0056616. Epub 2013 Feb 12.


Ligation of TLR2 by versican: a link between inflammation and metastasis.

Wang W, Xu GL, Jia WD, Ma JL, Li JS, Ge YS, Ren WH, Yu JH, Liu WB.

Arch Med Res. 2009 May;40(4):321-3. doi: 10.1016/j.arcmed.2009.04.005. Epub 2009 May 21.


Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)-alpha in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist-deficient mice.

Jung YO, Cho ML, Lee SY, Oh HJ, Park JS, Park MK, Park MJ, Ju JH, Kim SI, Park SH, Kim HY, Min JK.

Immunol Lett. 2009 Apr 27;123(2):138-43. doi: 10.1016/j.imlet.2009.03.004. Epub 2009 Mar 21.


Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins.

Chang S, Dolganiuc A, Szabo G.

J Leukoc Biol. 2007 Sep;82(3):479-87. Epub 2007 Jun 26.


CDA-2, a urinary preparation, inhibits lung cancer development through the suppression of NF-kappaB activation in myeloid cell.

Wang X, Jiang CM, Wan HY, Wu JL, Quan WQ, Bals R, Wu KY, Li D.

PLoS One. 2012;7(12):e52117. doi: 10.1371/journal.pone.0052117. Epub 2012 Dec 17.


Activation of Toll-like receptors by Burkholderia pseudomallei.

West TE, Ernst RK, Jansson-Hutson MJ, Skerrett SJ.

BMC Immunol. 2008 Aug 8;9:46. doi: 10.1186/1471-2172-9-46.


Mycoplasma genitalium-derived lipid-associated membrane proteins activate NF-kappaB through toll-like receptors 1, 2, and 6 and CD14 in a MyD88-dependent pathway.

He J, You X, Zeng Y, Yu M, Zuo L, Wu Y.

Clin Vaccine Immunol. 2009 Dec;16(12):1750-7. doi: 10.1128/CVI.00281-09. Epub 2009 Sep 30.


MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis.

Bowdish DM, Sakamoto K, Kim MJ, Kroos M, Mukhopadhyay S, Leifer CA, Tryggvason K, Gordon S, Russell DG.

PLoS Pathog. 2009 Jun;5(6):e1000474. doi: 10.1371/journal.ppat.1000474. Epub 2009 Jun 12.


Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.

Hise AG, Daehnel K, Gillette-Ferguson I, Cho E, McGarry HF, Taylor MJ, Golenbock DT, Fitzgerald KA, Kazura JW, Pearlman E.

J Immunol. 2007 Jan 15;178(2):1068-76.


Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.

Rubino I, Coste A, Le Roy D, Roger T, Jaton K, Boeckh M, Monod M, Latgé JP, Calandra T, Bochud PY.

J Infect Dis. 2012 Mar 15;205(6):944-54. doi: 10.1093/infdis/jir882. Epub 2012 Feb 7.


Induction of TLR2 expression by inflammatory stimuli is required for endothelial cell responses to lipopeptides.

Satta N, Kruithof EK, Reber G, de Moerloose P.

Mol Immunol. 2008 Nov;46(1):145-57. doi: 10.1016/j.molimm.2008.07.017. Epub 2008 Aug 23.


GM-CSF priming drives bone marrow-derived macrophages to a pro-inflammatory pattern and downmodulates PGE2 in response to TLR2 ligands.

Sorgi CA, Rose S, Court N, Carlos D, Paula-Silva FW, Assis PA, Frantz FG, Ryffel B, Quesniaux V, Faccioli LH.

PLoS One. 2012;7(7):e40523. doi: 10.1371/journal.pone.0040523. Epub 2012 Jul 13.


Toll-like receptor 6 senses Mycobacterium avium and is required for efficient control of mycobacterial infection.

Marinho FA, de Paula RR, Mendes AC, de Almeida LA, Gomes MT, Carvalho NB, Oliveira FS, Caliari MV, Oliveira SC.

Eur J Immunol. 2013 Sep;43(9):2373-85. doi: 10.1002/eji.201243208. Epub 2013 Jun 21.


Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans.

Quesniaux VJ, Nicolle DM, Torres D, Kremer L, Guérardel Y, Nigou J, Puzo G, Erard F, Ryffel B.

J Immunol. 2004 Apr 1;172(7):4425-34.

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