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Items: 1 to 20 of 189

1.

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.

Guo Z, Wu YW, Das D, Delon C, Cramer J, Yu S, Thuns S, Lupilova N, Waldmann H, Brunsveld L, Goody RS, Alexandrov K, Blankenfeldt W.

EMBO J. 2008 Sep 17;27(18):2444-56. doi: 10.1038/emboj.2008.164. Epub 2008 Aug 28.

2.

Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase.

Alexandrov K, Simon I, Yurchenko V, Iakovenko A, Rostkova E, Scheidig AJ, Goody RS.

Eur J Biochem. 1999 Oct 1;265(1):160-70.

3.

Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates.

Dursina B, Thomä NH, Sidorovitch V, Niculae A, Iakovenko A, Rak A, Albert S, Ceacareanu AC, Kölling R, Herrmann C, Goody RS, Alexandrov K.

Biochemistry. 2002 May 28;41(21):6805-16.

PMID:
12022885
4.

Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.

Thomä NH, Iakovenko A, Goody RS, Alexandrov K.

J Biol Chem. 2001 Dec 28;276(52):48637-43. Epub 2001 Oct 23.

5.

Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation.

Wu YW, Goody RS, Abagyan R, Alexandrov K.

J Biol Chem. 2009 May 8;284(19):13185-92. doi: 10.1074/jbc.M900579200. Epub 2009 Feb 24.

6.

Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate.

Thomä NH, Niculae A, Goody RS, Alexandrov K.

J Biol Chem. 2001 Dec 28;276(52):48631-6. Epub 2001 Oct 8.

7.

Single prenyl-binding site on protein prenyl transferases.

Desnoyers L, Seabra MC.

Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12266-70.

8.

In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex.

Rak A, Niculae A, Kalinin A, Thomä NH, Sidorovitch V, Goody RS, Alexandrov K.

Protein Expr Purif. 2002 Jun;25(1):23-30.

PMID:
12071695
9.

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.

Pylypenko O, Rak A, Reents R, Niculae A, Sidorovitch V, Cioaca MD, Bessolitsyna E, Thomä NH, Waldmann H, Schlichting I, Goody RS, Alexandrov K.

Mol Cell. 2003 Feb;11(2):483-94.

10.

Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II.

Thomä NH, Iakovenko A, Kalinin A, Waldmann H, Goody RS, Alexandrov K.

Biochemistry. 2001 Jan 9;40(1):268-74.

PMID:
11141079
11.

Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex.

Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC.

Biochemistry. 1998 Sep 8;37(36):12559-68.

PMID:
9730828
12.

Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.

Zhang H, Seabra MC, Deisenhofer J.

Structure. 2000 Mar 15;8(3):241-51.

13.

Semi-synthetic Rab proteins as tools for studying intermolecular interactions.

Iakovenko A, Rostkova E, Merzlyak E, Hillebrand AM, Thomä NH, Goody RS, Alexandrov K.

FEBS Lett. 2000 Feb 25;468(2-3):155-8.

14.

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.

Deraeve C, Guo Z, Bon RS, Blankenfeldt W, DiLucrezia R, Wolf A, Menninger S, Stigter EA, Wetzel S, Choidas A, Alexandrov K, Waldmann H, Goody RS, Wu YW.

J Am Chem Soc. 2012 May 2;134(17):7384-91. doi: 10.1021/ja211305j. Epub 2012 Apr 22.

PMID:
22480322
16.

Sequence dependence of protein isoprenylation.

Moores SL, Schaber MD, Mosser SD, Rands E, O'Hara MB, Garsky VM, Marshall MS, Pompliano DL, Gibbs JB.

J Biol Chem. 1991 Aug 5;266(22):14603-10.

17.
18.

Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.

Leung KF, Baron R, Seabra MC.

J Lipid Res. 2006 Mar;47(3):467-75. Epub 2006 Jan 9. Review.

19.

Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae.

Sidorovitch V, Niculae A, Kan N, Ceacareanu AC, Alexandrov K.

Protein Expr Purif. 2002 Oct;26(1):50-8.

PMID:
12356470
20.

Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases.

Wilson AL, Erdman RA, Castellano F, Maltese WA.

Biochem J. 1998 Aug 1;333 ( Pt 3):497-504.

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