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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1963 1
1986 1
1988 1
1989 1
1990 4
1992 1
1994 1
1997 1
1999 1
2001 2
2002 1
2003 1
2004 3
2005 6
2006 10
2007 19
2008 36
2009 18
2010 2
2011 1
2014 1
2024 0

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Similar articles for PMID: 18072721

102 results

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Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.
Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD. Pfefferkorn JA, et al. J Med Chem. 2008 Jan 10;51(1):31-45. doi: 10.1021/jm070849r. Epub 2007 Dec 12. J Med Chem. 2008. PMID: 18072721
Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
Pfefferkorn JA, Litchfield J, Hutchings R, Cheng XM, Larsen SD, Auerbach B, Bush MR, Lee C, Erasga N, Bowles DM, Boyles DC, Lu G, Sekerke C, Askew V, Hanselman JC, Dillon L, Lin Z, Robertson A, Olsen K, Boustany C, Atkinson K, Goosen TC, Sahasrabudhe V, Chupka J, Duignan DB, Feng B, Scialis R, Kimoto E, Bi YA, Lai Y, El-Kattan A, Bakker-Arkema R, Barclay P, Kindt E, Le V, Mandema JW, Milad M, Tait BD, Kennedy R, Trivedi BK, Kowala M. Pfefferkorn JA, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2725-31. doi: 10.1016/j.bmcl.2010.11.103. Epub 2010 Nov 26. Bioorg Med Chem Lett. 2011. PMID: 21183342
Pyrazole inhibitors of HMG-CoA reductase: an attempt to dramatically reduce synthetic complexity through minimal analog re-design.
Larsen SD, Poel TJ, Filipski KJ, Kohrt JT, Pfefferkorn JA, Sorenson RJ, Tait BD, Askew V, Dillon L, Hanselman JC, Lu GH, Robertson A, Sekerke C, Kowala MC, Auerbach BJ. Larsen SD, et al. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5567-72. doi: 10.1016/j.bmcl.2007.08.004. Epub 2007 Aug 11. Bioorg Med Chem Lett. 2007. PMID: 17764936
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.
Pfefferkorn JA, Song Y, Sun KL, Miller SR, Trivedi BK, Choi C, Sorenson RJ, Bratton LD, Unangst PC, Larsen SD, Poel TJ, Cheng XM, Lee C, Erasga N, Auerbach B, Askew V, Dillon L, Hanselman JC, Lin Z, Lu G, Robertson A, Olsen K, Mertz T, Sekerke C, Pavlovsky A, Harris MS, Bainbridge G, Caspers N, Chen H, Eberstadt M. Pfefferkorn JA, et al. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4538-44. doi: 10.1016/j.bmcl.2007.05.096. Epub 2007 Jun 6. Bioorg Med Chem Lett. 2007. PMID: 17574412
Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.
Park WK, Kennedy RM, Larsen SD, Miller S, Roth BD, Song Y, Steinbaugh BA, Sun K, Tait BD, Kowala MC, Trivedi BK, Auerbach B, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C. Park WK, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1151-6. doi: 10.1016/j.bmcl.2007.11.124. Epub 2007 Dec 5. Bioorg Med Chem Lett. 2008. PMID: 18155906
Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.
Pfefferkorn JA, Choi C, Song Y, Trivedi BK, Larsen SD, Askew V, Dillon L, Hanselman JC, Lin Z, Lu G, Robertson A, Sekerke C, Auerbach B, Pavlovsky A, Harris MS, Bainbridge G, Caspers N. Pfefferkorn JA, et al. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4531-7. doi: 10.1016/j.bmcl.2007.05.097. Epub 2007 Jun 6. Bioorg Med Chem Lett. 2007. PMID: 17574411
102 results