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Results: 1 to 20 of 680

1.

Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.

Güzel O, Temperini C, Innocenti A, Scozzafava A, Salman A, Supuran CT.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):152-8. Epub 2007 Nov 4.

PMID:
18024029
[PubMed - indexed for MEDLINE]
2.

Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.

Temperini C, Cecchi A, Boyle NA, Scozzafava A, Cabeza JE, Wentworth P Jr, Blackburn GM, Supuran CT.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):999-1005. Epub 2007 Dec 15.

PMID:
18162396
[PubMed - indexed for MEDLINE]
3.

Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.

Güzel O, Innocenti A, Scozzafava A, Salman A, Parkkila S, Hilvo M, Supuran CT.

Bioorg Med Chem. 2008 Oct 15;16(20):9113-20. doi: 10.1016/j.bmc.2008.09.032. Epub 2008 Sep 13.

PMID:
18819811
[PubMed - indexed for MEDLINE]
4.

Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.

Temperini C, Innocenti A, Mastrolorenzo A, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4866-72. Epub 2007 Jun 14.

PMID:
17588751
[PubMed - indexed for MEDLINE]
5.

Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?

Temperini C, Cecchi A, Scozzafava A, Supuran CT.

Org Biomol Chem. 2008 Jul 21;6(14):2499-506. doi: 10.1039/b800767e. Epub 2008 May 29.

PMID:
18600270
[PubMed - indexed for MEDLINE]
6.

Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.

Carta F, Garaj V, Maresca A, Wagner J, Avvaru BS, Robbins AH, Scozzafava A, McKenna R, Supuran CT.

Bioorg Med Chem. 2011 May 15;19(10):3105-19. doi: 10.1016/j.bmc.2011.04.005. Epub 2011 Apr 6.

PMID:
21515057
[PubMed - indexed for MEDLINE]
7.

Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.

Temperini C, Innocenti A, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. doi: 10.1016/j.bmcl.2008.06.105. Epub 2008 Jul 5.

PMID:
18640037
[PubMed - indexed for MEDLINE]
8.

Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.

Gitto R, Agnello S, Ferro S, De Luca L, Vullo D, Brynda J, Mader P, Supuran CT, Chimirri A.

J Med Chem. 2010 Mar 25;53(6):2401-8. doi: 10.1021/jm9014026.

PMID:
20170095
[PubMed - indexed for MEDLINE]
9.

Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.

Temperini C, Cecchi A, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2567-73. doi: 10.1016/j.bmcl.2008.03.051. Epub 2008 Mar 20.

PMID:
18374572
[PubMed - indexed for MEDLINE]
10.

3-phenyl-1H-indole-5-sulfonamides: structure-based drug design of a promising class of carbonic anhydrase inhibitors.

Güzel O, Innocenti A, Vullo D, Scozzafava A, Supuran CT.

Curr Pharm Des. 2010;16(29):3317-26. Review.

PMID:
20819062
[PubMed - indexed for MEDLINE]
11.

Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.

Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT.

J Am Chem Soc. 2006 Jun 28;128(25):8329-35.

PMID:
16787097
[PubMed - indexed for MEDLINE]
12.

Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II.

Di Fiore A, De Simone G, Menchise V, Pedone C, Casini A, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2005 Apr 1;15(7):1937-42.

PMID:
15780637
[PubMed - indexed for MEDLINE]
13.

Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.

Güzel O, Maresca A, Scozzafava A, Salman A, Balaban AT, Supuran CT.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2931-4. doi: 10.1016/j.bmcl.2009.04.068. Epub 2009 Apr 22.

PMID:
19410461
[PubMed - indexed for MEDLINE]
14.

Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.

Saczewski F, Innocenti A, Sławiński J, Kornicka A, Brzozowski Z, Pomarnacka E, Scozzafava A, Temperini C, Supuran CT.

Bioorg Med Chem. 2008 Apr 1;16(7):3933-40. doi: 10.1016/j.bmc.2008.01.034. Epub 2008 Jan 26.

PMID:
18242998
[PubMed - indexed for MEDLINE]
15.

Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.

Güzel O, Innocenti A, Hall RA, Scozzafava A, Mühlschlegel FA, Supuran CT.

Bioorg Med Chem. 2009 Apr 15;17(8):3212-5. doi: 10.1016/j.bmc.2009.01.048. Epub 2009 Jan 27.

PMID:
19201197
[PubMed - indexed for MEDLINE]
16.

Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides.

Pastorekova S, Vullo D, Casini A, Scozzafava A, Pastorek J, Nishimori I, Supuran CT.

J Enzyme Inhib Med Chem. 2005 Jun;20(3):211-7.

PMID:
16119190
[PubMed - indexed for MEDLINE]
17.

Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.

Puccetti L, Fasolis G, Vullo D, Chohan ZH, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2005 Jun 15;15(12):3096-101.

PMID:
15908204
[PubMed - indexed for MEDLINE]
18.

Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.

Güzel O, Innocenti A, Scozzafava A, Salman A, Supuran CT.

Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. doi: 10.1016/j.bmc.2009.06.006. Epub 2009 Jun 9.

PMID:
19539481
[PubMed - indexed for MEDLINE]
19.

Dissecting the inhibition mechanism of cytosolic versus transmembrane carbonic anhydrases by ESR.

Ciani L, Cecchi A, Temperini C, Supuran CT, Ristori S.

J Phys Chem B. 2009 Oct 22;113(42):13998-4005. doi: 10.1021/jp906593c.

PMID:
19778001
[PubMed - indexed for MEDLINE]
20.

Designing of novel carbonic anhydrase inhibitors and activators.

Supuran CT, Vullo D, Manole G, Casini A, Scozzafava A.

Curr Med Chem Cardiovasc Hematol Agents. 2004 Jan;2(1):49-68. Review.

PMID:
15328829
[PubMed - indexed for MEDLINE]

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