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Items: 1 to 20 of 93

1.

Crystal structure of the apo form of D-alanine: D-alanine ligase (Ddl) from Thermus caldophilus: a basis for the substrate-induced conformational changes.

Lee JH, Na Y, Song HE, Kim D, Park BH, Rho SH, Im YJ, Kim MK, Kang GB, Lee DS, Eom SH.

Proteins. 2006 Sep 1;64(4):1078-82. No abstract available.

PMID:
16779845
2.

Crystal structure of the Apo form of D-Alanine:D-Alanine ligase (DDl) from Streptococcus mutans.

Lu Y, Xu H, Zhao X.

Protein Pept Lett. 2010 Aug;17(8):1053-7.

PMID:
20522004
3.

Crystallization and preliminary crystallographic analysis of D-alanine-D-alanine ligase from Streptococcus mutans.

Lu YZ, Sheng Y, Li LF, Tang DW, Liu XY, Zhao X, Liang YH, Su XD.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Sep 1;63(Pt 9):807-8. Epub 2007 Aug 31.

4.

Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori.

Wu D, Zhang L, Kong Y, Du J, Chen S, Chen J, Ding J, Jiang H, Shen X.

Proteins. 2008 Sep;72(4):1148-60. doi: 10.1002/prot.22009.

PMID:
18320587
5.

Structure of D-alanine-D-alanine ligase from Thermus thermophilus HB8: cumulative conformational change and enzyme-ligand interactions.

Kitamura Y, Ebihara A, Agari Y, Shinkai A, Hirotsu K, Kuramitsu S.

Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1098-106. doi: 10.1107/S0907444909029710. Epub 2009 Sep 16.

6.

Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution.

Yan Y, Munshi S, Leiting B, Anderson MS, Chrzas J, Chen Z.

J Mol Biol. 2000 Dec 1;304(3):435-45.

PMID:
11090285
7.

Function of the D-alanine:D-alanine ligase lid loop: a molecular modeling and bioactivity study.

Hrast M, Vehar B, Turk S, Konc J, Gobec S, Janežič D.

J Med Chem. 2012 Aug 9;55(15):6849-56. doi: 10.1021/jm3006965. Epub 2012 Jul 26.

PMID:
22803830
8.

Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution.

Spraggon G, Schwarzenbacher R, Kreusch A, Lee CC, Abdubek P, Ambing E, Biorac T, Brinen LS, Canaves JM, Cambell J, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Eshagi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Hampton E, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kovarik JS, Kuhn P, Levin I, McMullan D, McPhillips TM, Miller MD, Morse A, Moy K, Ouyang J, Page R, Quijano K, Robb A, Stevens RC, van den Bedem H, Velasquez J, Vincent J, von Delft F, Wang X, West B, Wolf G, Xu Q, Hodgson KO, Wooley J, Lesley SA, Wilson IA.

Proteins. 2004 Jun 1;55(4):1078-81. No abstract available.

PMID:
15146505
9.

D-alanine:D-alanine ligase: phosphonate and phosphinate intermediates with wild type and the Y216F mutant.

Fan C, Park IS, Walsh CT, Knox JR.

Biochemistry. 1997 Mar 4;36(9):2531-8.

PMID:
9054558
10.

Conformational changes observed in enzyme crystal structures upon substrate binding.

Gutteridge A, Thornton J.

J Mol Biol. 2005 Feb 11;346(1):21-8. Epub 2004 Dec 23.

PMID:
15663924
11.

Crystal structure of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Thermus caldophilus.

Kim MK, Cho MK, Song HE, Kim D, Park BH, Lee JH, Kang GB, Kim SH, Im YJ, Lee DS, Eom SH.

Proteins. 2007 Feb 15;66(3):751-4. No abstract available.

PMID:
17120230
12.

Crystal structure of Thermus caldophilus phosphoglycerate kinase in the open conformation.

Lee JH, Im YJ, Bae J, Kim D, Kim MK, Kang GB, Lee DS, Eom SH.

Biochem Biophys Res Commun. 2006 Dec 1;350(4):1044-9. Epub 2006 Oct 6.

PMID:
17045964
13.

Crystal structures of d-alanine-d-alanine ligase from Xanthomonas oryzae pv. oryzae alone and in complex with nucleotides.

Doan TT, Kim JK, Ngo HP, Tran HT, Cha SS, Min Chung K, Huynh KH, Ahn YJ, Kang LW.

Arch Biochem Biophys. 2014 Mar 1;545:92-9. doi: 10.1016/j.abb.2014.01.009. Epub 2014 Jan 16.

PMID:
24440607
14.

Sequencing of the ddl gene and modeling of the mutated D-alanine:D-alanine ligase in glycopeptide-dependent strains of Enterococcus faecium.

Gholizadeh Y, Prevost M, Van Bambeke F, Casadewall B, Tulkens PM, Courvalin P.

Protein Sci. 2001 Apr;10(4):836-44.

15.

Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine.

Bruning JB, Murillo AC, Chacon O, Barletta RG, Sacchettini JC.

Antimicrob Agents Chemother. 2011 Jan;55(1):291-301. doi: 10.1128/AAC.00558-10. Epub 2010 Oct 18.

16.

Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening.

Kovac A, Konc J, Vehar B, Bostock JM, Chopra I, Janezic D, Gobec S.

J Med Chem. 2008 Dec 11;51(23):7442-8. doi: 10.1021/jm800726b.

PMID:
19053785
17.

Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies.

Liu S, Chang JS, Herberg JT, Horng MM, Tomich PK, Lin AH, Marotti KR.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15178-83. Epub 2006 Oct 2.

18.

The crystal structure of the D-alanine-D-alanine ligase from Acinetobacter baumannii suggests a flexible conformational change in the central domain before nucleotide binding.

Huynh KH, Hong MK, Lee C, Tran HT, Lee SH, Ahn YJ, Cha SS, Kang LW.

J Microbiol. 2015 Nov;53(11):776-82. doi: 10.1007/s12275-015-5475-8. Epub 2015 Oct 28.

PMID:
26502962
19.

Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.

Krajewski WW, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T, Mowbray SL.

J Mol Biol. 2008 Jan 4;375(1):217-28. Epub 2007 Oct 17.

PMID:
18005987
20.

Diazenedicarboxamides as inhibitors of D-alanine-D-alanine ligase (Ddl).

Kovac A, Majce V, Lenarsic R, Bombek S, Bostock JM, Chopra I, Polanc S, Gobec S.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):2047-54. Epub 2007 Jan 17.

PMID:
17267218
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