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Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells.

Lee LT, Huang YT, Hwang JJ, Lee PP, Ke FC, Nair MP, Kanadaswam C, Lee MT. Lee LT, et al. Anticancer Res. 2002 May-Jun;22(3):1615-27. Anticancer Res. 2002. PMID: 12168845

Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor.

Huang YT, Hwang JJ, Lee PP, Ke FC, Huang JH, Huang CJ, Kandaswami C, Middleton E Jr, Lee MT. Huang YT, et al. Br J Pharmacol. 1999 Nov;128(5):999-1010. doi: 10.1038/sj.bjp.0702879. Br J Pharmacol. 1999. PMID: 10556937 Free PMC article.

Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells.

Lee LT, Huang YT, Hwang JJ, Lee AY, Ke FC, Huang CJ, Kandaswami C, Lee PP, Lee MT. Lee LT, et al. Biochem Pharmacol. 2004 Jun 1;67(11):2103-14. doi: 10.1016/j.bcp.2004.02.023. Biochem Pharmacol. 2004. PMID: 15135307

Involvement of hepatocyte epidermal growth factor receptor mediated activation of mitogen-activated protein kinase signaling pathways in response to growth inhibition by a novel K vitamin.

Wang Z, Wang M, Carr BI. Wang Z, et al. J Cell Physiol. 2000 Jun;183(3):338-46. doi: 10.1002/(SICI)1097-4652(200006)183:3<338::AID-JCP6>3.0.CO;2-X. J Cell Physiol. 2000. PMID: 10797308

Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression.

Ahmad N, Gali H, Javed S, Agarwal R. Ahmad N, et al. Biochem Biophys Res Commun. 1998 Jun 18;247(2):294-301. doi: 10.1006/bbrc.1998.8748. Biochem Biophys Res Commun. 1998. PMID: 9642119

Differential expression and translocation of protein tyrosine phosphatase 1B-related proteins in ME-180 tumor cells expressing apoptotic sensitivity and resistance to tumor necrosis factor: potential interaction with epidermal growth factor receptor.

Perez M, Haschke B, Donato NJ. Perez M, et al. Oncogene. 1999 Jan 28;18(4):967-78. doi: 10.1038/sj.onc.1202368. Oncogene. 1999. PMID: 10023672

Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

Moyer JD, Barbacci EG, Iwata KK, Arnold L, Boman B, Cunningham A, DiOrio C, Doty J, Morin MJ, Moyer MP, Neveu M, Pollack VA, Pustilnik LR, Reynolds MM, Sloan D, Theleman A, Miller P. Moyer JD, et al. Cancer Res. 1997 Nov 1;57(21):4838-48. Cancer Res. 1997. PMID: 9354447

Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling.

Richter M, Ebermann R, Marian B. Richter M, et al. Nutr Cancer. 1999;34(1):88-99. doi: 10.1207/S15327914NC340113. Nutr Cancer. 1999. PMID: 10453447

Multiple mitogenic pathways in pancreatic cancer cells are blocked by a truncated epidermal growth factor receptor.

Matsuda K, Idezawa T, You XJ, Kothari NH, Fan H, Korc M. Matsuda K, et al. Cancer Res. 2002 Oct 1;62(19):5611-7. Cancer Res. 2002. PMID: 12359775

Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice.

Weber KL, Doucet M, Price JE, Baker C, Kim SJ, Fidler IJ. Weber KL, et al. Cancer Res. 2003 Jun 1;63(11):2940-7. Cancer Res. 2003. PMID: 12782601

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