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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 2
2004 2
2005 1
2007 1
2008 2
2010 1
2011 3
2012 3
2013 3
2014 1
2015 2
2016 3
2017 1
2018 1
2019 3
2020 1
2021 2
2023 1
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29 results

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Page 1
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
Kaelin WG Jr, Ratcliffe PJ. Kaelin WG Jr, et al. Among authors: ratcliffe pj. Mol Cell. 2008 May 23;30(4):393-402. doi: 10.1016/j.molcel.2008.04.009. Mol Cell. 2008. PMID: 18498744 Free article. Review.
HIF plays a central role in the transcriptional response to changes in oxygen availability. The PHD family of oxygen-dependent prolyl hydroxylases plays a pivotal role in regulating HIF stability. ...
HIF plays a central role in the transcriptional response to changes in oxygen availability. The PHD family of oxygen-dependent prolyl …
Oxygen sensors and angiogenesis.
Maxwell PH, Ratcliffe PJ. Maxwell PH, et al. Among authors: ratcliffe pj. Semin Cell Dev Biol. 2002 Feb;13(1):29-37. doi: 10.1006/scdb.2001.0287. Semin Cell Dev Biol. 2002. PMID: 11969369 Review.
Following modification HIF- alpha chains are captured by a ubiquitin ligase E3 complex containing the von Hippel-Lindau (VHL) tumour suppressor protein. The HIF prolyl hydroxylases (PHD enzymes) act as oxygen sensors regulating HIF, and hence angiogenesis. The PHD-H …
Following modification HIF- alpha chains are captured by a ubiquitin ligase E3 complex containing the von Hippel-Lindau (VHL) tumour suppres …
The human side of hypoxia-inducible factor.
Smith TG, Robbins PA, Ratcliffe PJ. Smith TG, et al. Among authors: ratcliffe pj. Br J Haematol. 2008 May;141(3):325-34. doi: 10.1111/j.1365-2141.2008.07029.x. Br J Haematol. 2008. PMID: 18410568 Free PMC article. Review.
HIF is primarily regulated by specific prolyl hydroxylase-domain enzymes (PHDs) that initiate its degradation via the von Hippel-Lindau tumour suppressor protein (VHL). The oxygen and iron dependency of PHD activity accounts for regulation of the pathway by both cellular o …
HIF is primarily regulated by specific prolyl hydroxylase-domain enzymes (PHDs) that initiate its degradation via the von Hippel-Lindau tumo …
Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma.
Eckardt L, Prange-Barczynska M, Hodson EJ, Fielding JW, Cheng X, Lima JDCC, Kurlekar S, Douglas G, Ratcliffe PJ, Bishop T. Eckardt L, et al. Among authors: ratcliffe pj. Endocr Relat Cancer. 2021 Oct 18;28(12):757-772. doi: 10.1530/ERC-21-0211. Endocr Relat Cancer. 2021. PMID: 34658364 Free PMC article.
The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes.
Ortmann BM, Burrows N, Lobb IT, Arnaiz E, Wit N, Bailey PSJ, Jordon LH, Lombardi O, Peñalver A, McCaffrey J, Seear R, Mole DR, Ratcliffe PJ, Maxwell PH, Nathan JA. Ortmann BM, et al. Among authors: ratcliffe pj. Nat Genet. 2021 Jul;53(7):1022-1035. doi: 10.1038/s41588-021-00887-y. Epub 2021 Jun 21. Nat Genet. 2021. PMID: 34155378 Free PMC article.
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW. Yamamoto A, et al. Among authors: ratcliffe pj. J Clin Invest. 2019 Jun 4;129(9):3640-3656. doi: 10.1172/JCI124099. J Clin Invest. 2019. PMID: 31162141 Free PMC article.
Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes which regulate HIFs. Genetic interventions on HIF/PHD pathways reveal multiple phenotypes that extend the known biology of hypoxia. ...To study these processes better we develop …
Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes which regulate HIFs. Genetic interventions o …
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates.
Cockman ME, Lippl K, Tian YM, Pegg HB, Figg WD Jnr, Abboud MI, Heilig R, Fischer R, Myllyharju J, Schofield CJ, Ratcliffe PJ. Cockman ME, et al. Among authors: ratcliffe pj. Elife. 2019 Sep 10;8:e46490. doi: 10.7554/eLife.46490. Elife. 2019. PMID: 31500697 Free PMC article.
We cannot exclude PHD-catalysed prolyl hydroxylation occurring under conditions other than those we have examined. However, our findings using recombinant enzymes provide no support for the wide range of non-HIF PHD substrates that have been reported....
We cannot exclude PHD-catalysed prolyl hydroxylation occurring under conditions other than those we have examined. However, our findi …
Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells.
Tian YM, Holdship P, To TQ, Ratcliffe PJ, Keeley TP. Tian YM, et al. Among authors: ratcliffe pj. J Biol Chem. 2023 Sep;299(9):105156. doi: 10.1016/j.jbc.2023.105156. Epub 2023 Aug 10. J Biol Chem. 2023. PMID: 37572852 Free PMC article.
Here, we set out to compare and contrast the in cellulo characteristics of ADO and PHD enzymes in an attempt to better understand their co-evolution in animals. We find that ADO operates to regulate the stability of its substrates rapidly and with similar O(2)-sensitivity …
Here, we set out to compare and contrast the in cellulo characteristics of ADO and PHD enzymes in an attempt to better understand the …
Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.
Holt-Martyn JP, Chowdhury R, Tumber A, Yeh TL, Abboud MI, Lippl K, Lohans CT, Langley GW, Figg W Jr, McDonough MA, Pugh CW, Ratcliffe PJ, Schofield CJ. Holt-Martyn JP, et al. Among authors: ratcliffe pj. ChemMedChem. 2020 Feb 5;15(3):270-273. doi: 10.1002/cmdc.201900557. Epub 2019 Dec 3. ChemMedChem. 2020. PMID: 31751494 Free PMC article.
The 2-oxoglutarate-dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The …
The 2-oxoglutarate-dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases includin …
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases.
Chan MC, Ilott NE, Schödel J, Sims D, Tumber A, Lippl K, Mole DR, Pugh CW, Ratcliffe PJ, Ponting CP, Schofield CJ. Chan MC, et al. Among authors: ratcliffe pj. J Biol Chem. 2016 Sep 23;291(39):20661-73. doi: 10.1074/jbc.M116.749291. Epub 2016 Aug 8. J Biol Chem. 2016. PMID: 27502280 Free PMC article.
PHD inhibitors with different structural scaffolds behave similarly. ...Indeed, combined application of selective PHD and FIH inhibitors resulted in the transcriptional induction of a subset of genes not fully responsive to PHD inhibition alone. ...
PHD inhibitors with different structural scaffolds behave similarly. ...Indeed, combined application of selective PHD and FIH …
29 results