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Page 1
Stroke genetics informs drug discovery and risk prediction across ancestries.
Nature. 2022 Nov;611(7934):115-123. doi: 10.1038/s41586-022-05165-3. Epub 2022 Sep 30.
Nature. 2022.
PMID: 36180795
Free PMC article.
NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition.
Joo HY, Jung JK, Kim MY, Woo SR, Jeong JM, Park ER, Kim YM, Park JJ, Kim J, Yun M, Shin HJ, Lee KH.
Joo HY, et al.
Cell Biosci. 2023 Sep 30;13(1):182. doi: 10.1186/s13578-023-01130-3.
Cell Biosci. 2023.
PMID: 37777750
Free PMC article.
METHODS: In this study, we investigated the effect of SIRT1 on HIF1 stability in a typical chronic hypoxic conditon that maintains cells for 24 h under hypoxia using Western blotting, co-IP, measurement of intracellular NAD + and NADH levels, semi-quantitative RT-PCR analy …
METHODS: In this study, we investigated the effect of SIRT1 on HIF1 stability in a typical chronic hypoxic conditon that maintains cells for …
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Inflammatory Bowel Disease in Children With Systemic Juvenile Idiopathic Arthritis.
Maller J, Fox E, Park KT, Paul SS, Baszis K, Borocco C, Prahalad S, Quartier P, Reinhardt A, Schonenberg-Meinema D, Shipman-Duensing L, Terreri MT, Simard J, Lavi I, Chalom E, Hsu J, Zisman D, Mellins ED; CARRA Legacy Registry Investigators.
Maller J, et al.
J Rheumatol. 2021 Apr;48(4):567-574. doi: 10.3899/jrheum.200230. Epub 2020 Jun 15.
J Rheumatol. 2021.
PMID: 32541073
Free PMC article.
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Insurance Status and Tumor Necrosis Factor Inhibitor Initiation Among Children With Juvenile Idiopathic Arthritis in the CARRA Registry.
Roberts JE, Williams K, Dallas J, Eckert M, Huie L, Smitherman E, Soulsby WD, Zhao Y, Son MBF; CARRA Registry Investigators.
Roberts JE, et al.
J Rheumatol. 2023 Aug;50(8):1047-1057. doi: 10.3899/jrheum.220871. Epub 2022 Dec 15.
J Rheumatol. 2023.
PMID: 36521922
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The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence.
Jung HJ, Byun HO, Jee BA, Min S, Jeoun UW, Lee YK, Seo Y, Woo HG, Yoon G.
Jung HJ, et al.
J Biol Chem. 2017 Mar 3;292(9):3729-3739. doi: 10.1074/jbc.M116.750539. Epub 2017 Jan 18.
J Biol Chem. 2017.
PMID: 28100769
Free PMC article.
Here we analyzed time series gene expression profiles obtained in two different senescence models in human diploid fibroblasts: replicative senescence and H(2)O(2)-induced senescence. Our results demonstrate that suppression of DNA methyltransferase 1 (DNMT1)-mediated DNA …
Here we analyzed time series gene expression profiles obtained in two different senescence models in human diploid fibroblasts: replicative …
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