Abstract
To potentially reduce late effects of malignancy and chronic graft-versus-host disease in patients with Fanconi anemia, 3 patients received unmanipulated umbilical cord blood grafts with 0 or 1 HLA antigen mismatch. The conditioning regimen consisted of fludarabine (30 mg/m/d) for 6 days, cyclophosphamide (60 mg/kg/d) for 2 days, and rabbit antithymocyte globulin (ATG) (2.5 mg/kg/d) for 3 days. Radiation was not used in the preparative regimen. None of the patients had significant conditioning-related toxicity. All were engrafted within 10 to 19 days. All patients are well with stable or full donor chimerism after a median follow-up of 64 months (range, 13 to 69 mo).
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antilymphocyte Serum / administration & dosage
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Antineoplastic Agents, Alkylating / administration & dosage
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Child, Preschool
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Chronic Disease
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Cord Blood Stem Cell Transplantation / adverse effects*
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Cord Blood Stem Cell Transplantation / methods*
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Cyclophosphamide / administration & dosage
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Fanconi Anemia / therapy*
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Graft vs Host Disease / therapy*
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Hematopoiesis / drug effects*
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Histocompatibility Testing
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Humans
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Immunosuppressive Agents / administration & dosage
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Infant
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Male
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Myeloablative Agonists / administration & dosage
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Rabbits
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Transplantation Conditioning / methods*
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Transplantation, Homologous
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Vidarabine / administration & dosage
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Vidarabine / analogs & derivatives
Substances
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Antilymphocyte Serum
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Antineoplastic Agents, Alkylating
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Immunosuppressive Agents
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Myeloablative Agonists
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Cyclophosphamide
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Vidarabine
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fludarabine