Acute promyelocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion genes

Blood. 1995 Mar 1;85(5):1169-74.

Abstract

Tumor-associated chromosome translocations usually lead to the formation of two reciprocal fusion genes: one thought to be involved in the transformation process, the other the mechanical consequence of the translocation event. In the case of acute promyelocytic leukemia (APL) blasts, the 15;17 chromosome translocation generates the putatively transforming PML/RARa fusion gene and its reciprocal RARa/PML. We report APL cases with submicroscopic 15;17 recombinations leading to the formation of nonreciprocal PML/RARa or RARa/PML fusion genes. Therefore, each of the two reciprocal translocation products may be independently formed and selected by the leukemic phenotype, implying that both are involved in tumorigenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosomes, Human, Pair 15 / ultrastructure*
  • Chromosomes, Human, Pair 17 / ultrastructure*
  • DNA, Neoplasm / genetics
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Leukemia, Promyelocytic, Acute / genetics*
  • Male
  • Molecular Sequence Data
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / physiology
  • Nuclear Proteins*
  • Oncogene Proteins, Fusion / genetics*
  • Oncogene Proteins, Fusion / physiology
  • Promyelocytic Leukemia Protein
  • Receptors, Retinoic Acid / genetics*
  • Retinoic Acid Receptor alpha
  • Transcription Factors / genetics*
  • Translocation, Genetic*
  • Tumor Suppressor Proteins

Substances

  • DNA, Neoplasm
  • Neoplasm Proteins
  • Nuclear Proteins
  • Oncogene Proteins, Fusion
  • Promyelocytic Leukemia Protein
  • RARA protein, human
  • Receptors, Retinoic Acid
  • Retinoic Acid Receptor alpha
  • Transcription Factors
  • Tumor Suppressor Proteins
  • PML protein, human