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Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.
Shen Q, Shi Y, Liu J, Su H, Huang J, Zhang Y, Peng C, Zhou T, Sun Q, Wan W, Liu W. Shen Q, et al. Autophagy. 2021 May;17(5):1157-1169. doi: 10.1080/15548627.2020.1752471. Epub 2020 Apr 15. Autophagy. 2021. PMID: 32264736 Free PMC article.
The fusion of autophagosomes and endosomes/lysosomes, also called autophagosome maturation, ensures the degradation of autophagic cargoes. ...Deacetylation of STX17 also enhances the interaction between STX17 and the tethering complex HOPS, thereby further promoting autoph …
The fusion of autophagosomes and endosomes/lysosomes, also called autophagosome maturation, ensures the degradation of autophagic car …
mTOR deletion ameliorates CD4 + T cell apoptosis during sepsis by improving autophagosome-lysosome fusion.
Wang H, Bai G, Chen J, Han W, Guo R, Cui N. Wang H, et al. Apoptosis. 2022 Jun;27(5-6):401-408. doi: 10.1007/s10495-022-01719-y. Epub 2022 Apr 18. Apoptosis. 2022. PMID: 35435531 Free PMC article.
We used T cell specific-mTOR/tuberous sclerosis complex 1 (TSC1)-knockout mice to explore the roles of the mTOR pathway in modulating autophagy during sepsis. ...Deletion of mTOR relieved autophagosome-lysosome fusion dysfunction and ameliorated apoptosis of …
We used T cell specific-mTOR/tuberous sclerosis complex 1 (TSC1)-knockout mice to explore the roles of the mTOR pathway in mod …
Generation and characterization of monoclonal antibodies against tuberous sclerosis complex 2.
Malanchuk O, Palchevskyy S, Ovcharenko G, Gwalter J, Pozur V, Gout I, Filonenko V. Malanchuk O, et al. Hybridoma (Larchmt). 2007 Aug;26(4):259-66. doi: 10.1089/hyb.2007.0503. Hybridoma (Larchmt). 2007. PMID: 17725389
TSC1 and TSC2 are two recently identified tumor suppressor genes encoding hamartin and tuberin, respectively. ...The specificity of generated antibody was also confirmed in TSC2(/) and TSC2(+/+) mouse embryo fibroblasts. In summary, the produced antibody is a useful …
TSC1 and TSC2 are two recently identified tumor suppressor genes encoding hamartin and tuberin, respectively. ...The specificity of g …
The TSC1 gene product hamartin interacts with NADE.
Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, Takamura A, Nanba E, Higaki K, Ohno K. Yasui S, et al. Mol Cell Neurosci. 2007 May;35(1):100-8. doi: 10.1016/j.mcn.2007.02.007. Epub 2007 Feb 12. Mol Cell Neurosci. 2007. PMID: 17355907
Immunofluorescence and immunoprecipitation confirmed the interaction of hamartin and NADE in cultured neurons and mouse brain lysate. Hamartin constitutively associated with NADE to prevent its proteasomal degradation. Suppression of hamartin with TSC1 small interfe …
Immunofluorescence and immunoprecipitation confirmed the interaction of hamartin and NADE in cultured neurons and mouse brain lysate. …
The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.
Matthew EM, Hart LS, Astrinidis A, Navaraj A, Dolloff NG, Dicker DT, Henske EP, El-Deiry WS. Matthew EM, et al. Cell Cycle. 2009 Dec 15;8(24):4168-75. doi: 10.4161/cc.8.24.10800. Cell Cycle. 2009. PMID: 20054236 Free PMC article.
We found that human lung tumor cells deficient in Plk2 grew larger than control tumors, and that Plk2 interacts with endogenous TSC1 protein. Additionally, C-terminal Plk2-GST fusion protein bound both TSC1 and TSC2 proteins. ...Plk2 levels did not increase i …
We found that human lung tumor cells deficient in Plk2 grew larger than control tumors, and that Plk2 interacts with endogenous TSC1 …
The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.
Kathage B, Gehlert S, Ulbricht A, Lüdecke L, Tapia VE, Orfanos Z, Wenzel D, Bloch W, Volkmer R, Fleischmann BK, Fürst DO, Höhfeld J. Kathage B, et al. Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):62-75. doi: 10.1016/j.bbamcr.2016.10.007. Epub 2016 Oct 15. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 27756573 Free article.
The cochaperone utilizes its WW domain to contact a proline-rich motif in the tuberous sclerosis protein TSC1 that functions as an mTORC1 inhibitor in association with TSC2. ...In human muscle, an exercise-induced association of TSC1 with the cytoskeleton coincides …
The cochaperone utilizes its WW domain to contact a proline-rich motif in the tuberous sclerosis protein TSC1 that functions as an mT …
mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development.
Peng H, Liu J, Sun Q, Chen R, Wang Y, Duan J, Li C, Li B, Jing Y, Chen X, Mao Q, Xu KF, Walker CL, Li J, Wang J, Zhang H. Peng H, et al. Oncogene. 2013 Sep 26;32(39):4702-11. doi: 10.1038/onc.2012.481. Epub 2012 Oct 29. Oncogene. 2013. PMID: 23108404 Free PMC article.
Hyperactive mTOR signaling due to the loss-of-function of mutations in either TSC1 or TSC2 gene causes TSC, an autosomal dominant disorder featured with benign tumors in multiple organs. ...
Hyperactive mTOR signaling due to the loss-of-function of mutations in either TSC1 or TSC2 gene causes TSC, an autosomal dominant dis …
The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1.
Fidalgo da Silva E, Ansari SB, Maimaiti J, Barnes EA, Kong-Beltran M, Donoghue DJ, Porter LA. Fidalgo da Silva E, et al. Cell Cycle. 2011 Sep 15;10(18):3129-39. doi: 10.4161/cc.10.18.17296. Epub 2011 Sep 15. Cell Cycle. 2011. PMID: 21900748
The syndrome is initiated by a mutation in one of two tumor suppressor genes, TSC1 or TSC2, that encode for the proteins hamartin and tuberin, respectively. ...
The syndrome is initiated by a mutation in one of two tumor suppressor genes, TSC1 or TSC2, that encode for the proteins hamartin and …