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Scaffold protein SH3BP2 signalosome is pivotal for immune activation in nephrotic syndrome.
Srivastava T, Garola RE, Zhou J, Boinpelly VC, Rezaiekhaligh MH, Joshi T, Jiang Y, Ebadi D, Sharma S, Sethna C, Staggs VS, Sharma R, Gipson DS, Hao W, Wang Y, Mariani LH, Hodgin JB, Rottapel R, Yoshitaka T, Ueki Y, Sharma M. Srivastava T, et al. JCI Insight. 2024 Feb 8;9(3):e170055. doi: 10.1172/jci.insight.170055. JCI Insight. 2024. PMID: 38127456 Free PMC article.
Bioinformatic analysis of human glomerular transcriptome (Nephrotic Syndrome Study Network cohort) revealed upregulated SH3BP2 in MCD and FSGS. ...Sh3bp2KI/KI kidney morphology appeared normal except for increased mesangial cellularity and patchy foot process fus …
Bioinformatic analysis of human glomerular transcriptome (Nephrotic Syndrome Study Network cohort) revealed upregulated SH3BP2 …
The chaperone protein 14-3-3 interacts with 3BP2/SH3BP2 and regulates its adapter function.
Foucault I, Liu YC, Bernard A, Deckert M. Foucault I, et al. J Biol Chem. 2003 Feb 28;278(9):7146-53. doi: 10.1074/jbc.M209509200. Epub 2002 Dec 24. J Biol Chem. 2003. PMID: 12501243 Free article.
We previously showed that the cytoplasmic adapter 3BP2 (also known as SH3BP2) promotes NFAT/AP-1 transcriptional activities in T cells through the activation of Ras- and calcineurin-dependent pathways. However, the molecular mechanisms by which 3BP2/SH3BP2 regulates …
We previously showed that the cytoplasmic adapter 3BP2 (also known as SH3BP2) promotes NFAT/AP-1 transcriptional activities in T cell …
The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor.
Foucault I, Le Bras S, Charvet C, Moon C, Altman A, Deckert M. Foucault I, et al. Blood. 2005 Feb 1;105(3):1106-13. doi: 10.1182/blood-2003-08-2965. Epub 2004 Sep 2. Blood. 2005. PMID: 15345594 Free article.
Engagement of the B-cell antigen receptor (BCR) activates kinases of the Src and Syk families and signaling complexes assembled by adaptor proteins, which dictate B-cell fate and function. The adaptor 3BP2/SH3BP2, an Abl Src homology domain 3 (SH3)-binding and Syk-kinases …
Engagement of the B-cell antigen receptor (BCR) activates kinases of the Src and Syk families and signaling complexes assembled by adaptor p …