Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2008 1
2009 4
2010 2
2011 2
2012 5
2013 2
2014 6
2015 2
2016 2
2017 4
2018 4
2019 2
2020 5
2021 4
2022 1
2023 3
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

43 results

Results by year

Filters applied: . Clear all
Page 1
LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles.
Qiao L, Hu J, Qiu X, Wang C, Peng J, Zhang C, Zhang M, Lu H, Chen W. Qiao L, et al. Autophagy. 2023 Nov;19(11):2837-2852. doi: 10.1080/15548627.2023.2235196. Epub 2023 Jul 21. Autophagy. 2023. PMID: 37469132 Free PMC article. Review.
LAMP2A serves as a receptor and channel for transporting cytosolic proteins in a process called chaperone-mediated autophagy (CMA). LAMP2B is required for autophagosome-lysosome fusion in cardiomyocytes and is one of the components of exosome membranes. ...In this review, …
LAMP2A serves as a receptor and channel for transporting cytosolic proteins in a process called chaperone-mediated autophagy (CMA). LAMP2B i …
Modeling Parkinson's Disease in C. elegans.
Cooper JF, Van Raamsdonk JM. Cooper JF, et al. J Parkinsons Dis. 2018;8(1):17-32. doi: 10.3233/JPD-171258. J Parkinsons Dis. 2018. PMID: 29480229 Free PMC article. Review.
A number of C. elegans models of PD have been generated including transgenic worms that express alpha-synuclein or LRRK2, and worms with deletions in PRKN/pdr-1, PINK1/pink-1, DJ-1/djr-1.1/djr-1.2 and ATP13A2/catp-6. ...
A number of C. elegans models of PD have been generated including transgenic worms that express alpha-synuclein or LRRK2, and worms w …
LRRK2 and vesicle trafficking.
Sanna G, Del Giudice MG, Crosio C, Iaccarino C. Sanna G, et al. Biochem Soc Trans. 2012 Oct;40(5):1117-22. doi: 10.1042/BST20120117. Biochem Soc Trans. 2012. PMID: 22988875 Review.
To date, mutations in LRRK2 are a major genetic risk factor for familial and sporadic PD. ...The present paper reviews recent evidence regarding a potential role of LRRK2 in the regulation of membrane trafficking from vesicle generation to the movement along cytoske …
To date, mutations in LRRK2 are a major genetic risk factor for familial and sporadic PD. ...The present paper reviews recent evidenc …
Mitochondrial biogenesis: pharmacological approaches.
Valero T. Valero T. Curr Pharm Des. 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. Curr Pharm Des. 2014. PMID: 24606795
These alterations may have their origin on pathogenic gene mutations in important genes such as DJ-1, -syn, parkin, PINK1 or LRRK2. These mutations, in turn, may cause defects in mitochondrial dynamics (key events like fission/fusion, biogenesis, trafficking in retr …
These alterations may have their origin on pathogenic gene mutations in important genes such as DJ-1, -syn, parkin, PINK1 or LRRK2. T …
Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis.
Root J, Merino P, Nuckols A, Johnson M, Kukar T. Root J, et al. Neurobiol Dis. 2021 Jul;154:105360. doi: 10.1016/j.nbd.2021.105360. Epub 2021 Mar 31. Neurobiol Dis. 2021. PMID: 33812000 Free PMC article. Review.
Furthermore, some genes that cause FTD or ALS when mutated encode proteins that localize to the lysosome or modulate endosome-lysosome function, including lysosomal fusion, cargo trafficking, lysosomal acidification, autophagy, or TFEB activity. ...Mutations or polymorphis …
Furthermore, some genes that cause FTD or ALS when mutated encode proteins that localize to the lysosome or modulate endosome-lysosome funct …
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Wu MY, Liu L, Wang EJ, Xiao HT, Cai CZ, Wang J, Su H, Wang Y, Tan J, Zhang Z, Wang J, Yao M, Ouyang DF, Yue Z, Li M, Chen Y, Bian ZX, Lu JH. Wu MY, et al. Autophagy. 2021 May;17(5):1096-1111. doi: 10.1080/15548627.2020.1741332. Epub 2020 Mar 19. Autophagy. 2021. PMID: 32160108 Free PMC article.
Mechanistically, NRBF2 is required for the generation of the active form of RAB7 to promote the fusion between phagosomes containing engulfed apoptotic cells and lysosomes via interacting with the MON1-CCZ1 complex and regulating the guanine nucleotide exchange factor (GEF …
Mechanistically, NRBF2 is required for the generation of the active form of RAB7 to promote the fusion between phagosomes containing …
Mitochondria and neuroplasticity.
Cheng A, Hou Y, Mattson MP. Cheng A, et al. ASN Neuro. 2010 Oct 4;2(5):e00045. doi: 10.1042/AN20100019. ASN Neuro. 2010. PMID: 20957078 Free PMC article. Review.
Structural interface between LRRK2 and 14-3-3 protein.
Stevers LM, de Vries RM, Doveston RG, Milroy LG, Brunsveld L, Ottmann C. Stevers LM, et al. Biochem J. 2017 Mar 23;474(7):1273-1287. doi: 10.1042/BCJ20161078. Biochem J. 2017. PMID: 28202711
Abrogation of this interaction is connected to enhanced LRRK2 kinase activity, which in turn is implicated in increased ubiquitination of LRRK2, accumulation of LRRK2 into inclusion bodies and reduction in neurite length. Hence, the interaction between 14-3-3 …
Abrogation of this interaction is connected to enhanced LRRK2 kinase activity, which in turn is implicated in increased ubiquitinatio …
LRRK2 at the pre-synaptic site: A 16-years perspective.
Pischedda F, Piccoli G. Pischedda F, et al. J Neurochem. 2021 Apr;157(2):297-311. doi: 10.1111/jnc.15240. Epub 2021 Feb 5. J Neurochem. 2021. PMID: 33206398 Free article. Review.
Missense mutations in the leucine-rich repeat protein kinase-2 gene (LRRK2) are a recognized cause of inherited Parkinson's disease. The physiological and pathological impact of LRRK2 is still obscure, but accumulating evidence indicates that LRRK2 orchestrat …
Missense mutations in the leucine-rich repeat protein kinase-2 gene (LRRK2) are a recognized cause of inherited Parkinson's disease. …
Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology.
Fujimoto T, Kuwahara T, Eguchi T, Sakurai M, Komori T, Iwatsubo T. Fujimoto T, et al. Biochem Biophys Res Commun. 2018 Jan 8;495(2):1708-1715. doi: 10.1016/j.bbrc.2017.12.024. Epub 2017 Dec 6. Biochem Biophys Res Commun. 2018. PMID: 29223392
LRRK2 is implicated in the regulation of intracellular trafficking, neurite outgrowth and PD risk in connection with Rab7L1, a putative interactor of LRRK2. Recently, a subset of Rab GTPases have been reported as substrates of LRRK2. Here we examine the kinas …
LRRK2 is implicated in the regulation of intracellular trafficking, neurite outgrowth and PD risk in connection with Rab7L1, a putati …
43 results