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69 results

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Page 1
CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux.
Zhan Q, Jeon J, Li Y, Huang Y, Xiong J, Wang Q, Xu TL, Li Y, Ji FH, Du G, Zhu MX. Zhan Q, et al. Autophagy. 2022 Apr;18(4):726-744. doi: 10.1080/15548627.2021.1954348. Epub 2021 Jul 20. Autophagy. 2022. PMID: 34282994 Free PMC article.
Recent studies also implicate a role of MLKL in endosomal trafficking, which is not always dependent on RIPK3. Using mouse Neuro-2a and L929 as well as human HEK293 and HT29 cells, we show here that MLKL is phosphorylated in response to serum and amino acid deprivation fro …
Recent studies also implicate a role of MLKL in endosomal trafficking, which is not always dependent on RIPK3. Using mouse Neuro-2a and L929 …
MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration.
Feng Q, Luo Y, Zhang XN, Yang XF, Hong XY, Sun DS, Li XC, Hu Y, Li XG, Zhang JF, Li X, Yang Y, Wang Q, Liu GP, Wang JZ. Feng Q, et al. Autophagy. 2020 Apr;16(4):641-658. doi: 10.1080/15548627.2019.1633862. Epub 2019 Jun 28. Autophagy. 2020. PMID: 31223056 Free PMC article.
Macroautophagy/autophagy deficit induces intracellular MAPT/tau accumulation, the hallmark pathology in Alzheimer disease (AD) and other tauopathies; however, the reverse role of MAPT accumulation in autophagy and neurodegeneration is not clear. Here, we found that overexpression …
Macroautophagy/autophagy deficit induces intracellular MAPT/tau accumulation, the hallmark pathology in Alzheimer disease (AD) and other tau …
GSK-3β orchestrates the inhibitory innervation of adult-born dentate granule cells in vivo.
Moreno-Jiménez EP, Flor-García M, Hernández-Vivanco A, Terreros-Roncal J, Rodríguez-Moreno CB, Toni N, Méndez P, Llorens-Martín M. Moreno-Jiménez EP, et al. Cell Mol Life Sci. 2023 Jul 23;80(8):225. doi: 10.1007/s00018-023-04874-w. Cell Mol Life Sci. 2023. PMID: 37481766 Free PMC article.
GABA is a master regulator of adult and developmental neurogenesis. Here we engineered a novel retrovirus encoding the fusion protein Gephyrin:GFP to longitudinally study the formation and maturation of inhibitory synapses during adult hippocampal neurogenesis in vivo. ...
GABA is a master regulator of adult and developmental neurogenesis. Here we engineered a novel retrovirus encoding the fusion protein …
Characterization and functional aspects of human ninein isoforms that regulated by centrosomal targeting signals and evidence for docking sites to direct gamma-tubulin.
Lin CC, Cheng TS, Hsu CM, Wu CH, Chang LS, Shen ZS, Yeh HM, Chang LK, Howng SL, Hong YR. Lin CC, et al. Cell Cycle. 2006 Nov 1;5(21):2517-27. doi: 10.4161/cc.5.21.3404. Epub 2006 Sep 13. Cell Cycle. 2006. PMID: 17102634
The functions of centrosomal protein ninein may be involved in microtubule minus end capping, centriole positioning, protein anchoring and microtubule nucleation, but the true physiological function of various human hNinein isoforms remains to be determined. Here we descri …
The functions of centrosomal protein ninein may be involved in microtubule minus end capping, centriole positioning, protein anchoring and m …
TFR1 knockdown alleviates iron overload and mitochondrial dysfunction during neural differentiation of Alzheimer's disease-derived induced pluripotent stem cells by interacting with GSK3B.
Kang T, Han Z, Zhu L, Cao B. Kang T, et al. Eur J Med Res. 2024 Feb 6;29(1):101. doi: 10.1186/s40001-024-01677-y. Eur J Med Res. 2024. PMID: 38321571 Free PMC article.
Additionally, TFR1interacted with glycogen synthase kinase 3 beta (GSK3B) and promoted GSK3B expression. GSK3B overexpression reversed the inhibitory effects of TFR1 knockdown on iron overload and mitochondrial dysfunction in AD-iPS differentiated neural cell …
Additionally, TFR1interacted with glycogen synthase kinase 3 beta (GSK3B) and promoted GSK3B expression. GSK3B overexpr …
Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen-Synthease-Kinase-3-Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo.
Clough BH, Zeitouni S, Krause U, Chaput CD, Cross LM, Gaharwar AK, Gregory CA. Clough BH, et al. Stem Cells Transl Med. 2018 Apr;7(4):342-353. doi: 10.1002/sctm.17-0229. Epub 2018 Feb 5. Stem Cells Transl Med. 2018. PMID: 29405665 Free PMC article.
One way to achieve this goal is to stimulate canonical Wingless (cWnt) signaling in bone marrow-resident human mesenchymal stem cells (hMSCs), the presumptive precursors of osteoblasts in bone marrow. ...Very-rapid-exposure-to-BIO (VRE-BIO) on either hMSCs or whole hBM res …
One way to achieve this goal is to stimulate canonical Wingless (cWnt) signaling in bone marrow-resident human mesenchymal stem cells …
Drp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes model.
Huang S, Wang Y, Gan X, Fang D, Zhong C, Wu L, Hu G, Sosunov AA, McKhann GM, Yu H, Yan SS. Huang S, et al. Diabetes. 2015 May;64(5):1728-42. doi: 10.2337/db14-0758. Epub 2014 Nov 20. Diabetes. 2015. PMID: 25412623 Free PMC article.
The underlying mechanisms and strategies to rescue such injury and dysfunction are not well understood. Using a mouse model of type 2 diabetes (db/db mice) and a human neuronal cell line treated with high concentration of glucose, we demonstrate aberrant mitochondrial morp …
The underlying mechanisms and strategies to rescue such injury and dysfunction are not well understood. Using a mouse model of type 2 diabet …
Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice.
Cheng YY, Chou YT, Lai FJ, Jan MS, Chang TH, Jou IM, Chen PS, Lo JY, Huang SS, Chang NS, Liou YT, Hsu PC, Cheng HC, Lin YS, Hsu LJ. Cheng YY, et al. Acta Neuropathol Commun. 2020 Jan 30;8(1):6. doi: 10.1186/s40478-020-0883-3. Acta Neuropathol Commun. 2020. PMID: 32000863 Free PMC article.
Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreductase. ...Together, our findings reveal that the neurodevelopmental and neurodegenerative deficits in Wwox knockout mice strikingly recapitula …
Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreduct …
Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β.
Jiang J, Wang ZH, Qu M, Gao D, Liu XP, Zhu LQ, Wang JZ. Jiang J, et al. Sci Rep. 2015 Jun 29;5:11765. doi: 10.1038/srep11765. Sci Rep. 2015. PMID: 26119563 Free PMC article.
Here, we find that activation of endogenous EphB2 receptor by ligand stimulation (ephrinB1/Fc) or by ectopic expression of EphB2 plus the ligand stimulation induces a remarkable tau dephosphorylation at multiple AD-associated sites in SK-N-SH cells and human embryonic kidn …
Here, we find that activation of endogenous EphB2 receptor by ligand stimulation (ephrinB1/Fc) or by ectopic expression of EphB2 plus the li …
Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of beta-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.
Briolotti P, Chaloin L, Balaguer P, Da Silva F, Tománková V, Pascussi JM, Duret C, Fabre JM, Ramos J, Klieber S, Maurel P, Daujat-Chavanieu M, Gerbal-Chaloin S. Briolotti P, et al. Toxicol Sci. 2015 Nov;148(1):261-75. doi: 10.1093/toxsci/kfv177. Epub 2015 Aug 10. Toxicol Sci. 2015. PMID: 26259606
The wingless-type MMTV integration site family (WNT)/beta-catenin pathway was identified as a major regulator of this zonal organization. We have recently demonstrated that in primary human hepatocytes (PHHs), the expression of CYP2E1, CYP1A2, and aryl hydrocarbon receptor …
The wingless-type MMTV integration site family (WNT)/beta-catenin pathway was identified as a major regulator of this zonal organization. We …
69 results