Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2002 1
2003 1
2004 1
2005 1
2006 3
2007 2
2008 1
2011 2
2012 2
2013 1
2014 6
2015 3
2018 1
2019 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

23 results

Results by year

Filters applied: . Clear all
Page 1
miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 and BAX Proapoptotic Genes.
Hu T, Chong Y, Lu S, Wang R, Qin H, Silva J, Kitamura E, Chang CS, Hawthorn L, Cowell JK. Hu T, et al. Cancer Res. 2018 Jul 1;78(13):3522-3531. doi: 10.1158/0008-5472.CAN-17-4049. Epub 2018 May 7. Cancer Res. 2018. PMID: 29735550 Free PMC article.
In a screen to identify targets of miR-339-5p, we identified and verified the BCL2L11 and BAX genes, which can promote apoptosis. In vivo, SCLL cells forced to overexpress miR-339-5p show a more rapid onset of disease and poorer survival compared with parental cells expres …
In a screen to identify targets of miR-339-5p, we identified and verified the BCL2L11 and BAX genes, which can promote apoptosis. In …
Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine.
Vucicevic L, Misirkic-Marjanovic M, Paunovic V, Kravic-Stevovic T, Martinovic T, Ciric D, Maric N, Petricevic S, Harhaji-Trajkovic L, Bumbasirevic V, Trajkovic V. Vucicevic L, et al. Autophagy. 2014;10(12):2362-78. doi: 10.4161/15548627.2014.984270. Autophagy. 2014. PMID: 25551567 Free PMC article.
Olanzapine induced autophagy in human SH-SY5Y neuronal cell line, as confirmed by the increase in autophagic flux and presence of autophagic vesicles, fusion of autophagosomes with lysosomes, and increase in the expression of autophagy-related (ATG) genes ATG4B, ATG5, and …
Olanzapine induced autophagy in human SH-SY5Y neuronal cell line, as confirmed by the increase in autophagic flux and presence of autophagic …
GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells.
Joha S, Nugues AL, Hétuin D, Berthon C, Dezitter X, Dauphin V, Mahon FX, Roche-Lestienne C, Preudhomme C, Quesnel B, Idziorek T. Joha S, et al. Oncogene. 2012 Mar 15;31(11):1419-30. doi: 10.1038/onc.2011.328. Epub 2011 Aug 1. Oncogene. 2012. PMID: 21804606 Free PMC article.
Here, we show that the glucocorticoid-induced leucine zipper protein (GILZ) modulates imatinib and dasatinib resistance and suppresses tumor growth by inactivating the mammalian target of rapamycin complex-2 (mTORC2)/AKT signaling pathway. In mouse and human models, GILZ b …
Here, we show that the glucocorticoid-induced leucine zipper protein (GILZ) modulates imatinib and dasatinib resistance and suppresses tumor …
Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis.
Renault TT, Floros KV, Elkholi R, Corrigan KA, Kushnareva Y, Wieder SY, Lindtner C, Serasinghe MN, Asciolla JJ, Buettner C, Newmeyer DD, Chipuk JE. Renault TT, et al. Mol Cell. 2015 Jan 8;57(1):69-82. doi: 10.1016/j.molcel.2014.10.028. Epub 2014 Dec 4. Mol Cell. 2015. PMID: 25482509 Free PMC article.
Complementary biochemical, cellular, in vivo, and ex vivo studies reveal that Mfn1, a GTPase involved in mitochondrial fusion, establishes a mitochondrial size that is permissive for proapoptotic BCL-2 family function. ...
Complementary biochemical, cellular, in vivo, and ex vivo studies reveal that Mfn1, a GTPase involved in mitochondrial fusion, establ …
Piperlongumine-induced nuclear translocation of the FOXO3A transcription factor triggers BIM-mediated apoptosis in cancer cells.
Liu Z, Shi Z, Lin J, Zhao S, Hao M, Xu J, Li Y, Zhao Q, Tao L, Diao A. Liu Z, et al. Biochem Pharmacol. 2019 May;163:101-110. doi: 10.1016/j.bcp.2019.02.012. Epub 2019 Feb 10. Biochem Pharmacol. 2019. PMID: 30753811
We report here that an association of FOXO3A with the pro-apoptotic protein BIM (also known as BCL2-like 11, BCL2L11) has a direct and specific function in PL-induced cancer cell death. Using HeLa cells stably expressing a FOXO3A-GFP fusion protein and several other …
We report here that an association of FOXO3A with the pro-apoptotic protein BIM (also known as BCL2-like 11, BCL2L11) has a direct an …
NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis.
Xue L, Pulikkan JA, Valk PJ, Castilla LH. Xue L, et al. Blood. 2014 Jul 17;124(3):426-36. doi: 10.1182/blood-2013-12-541730. Epub 2014 Jun 3. Blood. 2014. PMID: 24894773 Free PMC article.
However, the combined function of CBFbeta-SMMHC and cooperating mutations in preleukemic expansion is not known. Here, we used Nras(LSL-G12D); Cbfb(56M) knock-in mice to show that allelic expression of oncogenic Nras(G12D) and Cbfbeta-SMMHC increases survival of preleukemi …
However, the combined function of CBFbeta-SMMHC and cooperating mutations in preleukemic expansion is not known. Here, we used Nras(LSL-G12D …
Antitumor activity of S116836, a novel tyrosine kinase inhibitor, against imatinib-resistant FIP1L1-PDGFRα-expressing cells.
Shen Y, Ren X, Ding K, Zhang Z, Wang D, Pan J. Shen Y, et al. Oncotarget. 2014 Nov 15;5(21):10407-20. doi: 10.18632/oncotarget.2090. Oncotarget. 2014. PMID: 25431951 Free PMC article.
The FIP1-like-1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRalpha) fusion oncogene is the driver factor in a subset of patients with hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL). ...S116836 effectively inhibited the growth of the WT a …
The FIP1-like-1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRalpha) fusion oncogene is the driver factor in a subset of …
Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.
Essafi A, Fernández de Mattos S, Hassen YA, Soeiro I, Mufti GJ, Thomas NS, Medema RH, Lam EW. Essafi A, et al. Oncogene. 2005 Mar 31;24(14):2317-29. doi: 10.1038/sj.onc.1208421. Oncogene. 2005. PMID: 15688014
In this study, we have used the human BV173 and the mouse BaF3/Bcr-Abl-expressing cell lines as model systems to investigate the molecular mechanisms whereby STI571 and FoxO3a regulate Bim expression and apoptosis. ...
In this study, we have used the human BV173 and the mouse BaF3/Bcr-Abl-expressing cell lines as model systems to investigate the mole …
Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice.
Herold MJ, Stuchbery R, Mérino D, Willson T, Strasser A, Hildeman D, Bouillet P. Herold MJ, et al. Cell Death Dis. 2014 Oct 9;5(10):e1446. doi: 10.1038/cddis.2014.409. Cell Death Dis. 2014. PMID: 25299771 Free PMC article.
To address this issue and allow the deletion of BIM in specific cell types in future studies, we have developed a mouse strain with a conditional Bim allele as well as a new Cre transgenic strain, Vav-CreER, in which the tamoxifen-inducible CreER recombinase (fusion …
To address this issue and allow the deletion of BIM in specific cell types in future studies, we have developed a mouse strain with a …
23 results