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The following terms were not found in PubMed: AC092687.2, AC092687.2
Page 1
In silico exploration and molecular dynamics of deleterious SNPs on the human TERF1 protein triggering male infertility.
Harmak H, Redouane S, Charoute H, Aniq Filali O, Barakat A, Rouba H. Harmak H, et al. J Biomol Struct Dyn. 2023;41(24):14665-14688. doi: 10.1080/07391102.2023.2193995. Epub 2023 Mar 30. J Biomol Struct Dyn. 2023. PMID: 36995171
By limiting chromosome erosion and end-to-end fusions, telomere integrity is critical for chromosome stability and cell survival. ...Several reports about TERF1 gene variations have been associated with different diseases, and some of them have linked these variatio …
By limiting chromosome erosion and end-to-end fusions, telomere integrity is critical for chromosome stability and cell survival. ... …
Characterization of the telomere complex, TERF1 and TERF2 genes in muntjac species with fusion karyotypes.
Hartmann N, Scherthan H. Hartmann N, et al. Exp Cell Res. 2005 May 15;306(1):64-74. doi: 10.1016/j.yexcr.2005.02.001. Exp Cell Res. 2005. PMID: 15878333
Chromosome evolution in the genus Muntiacus is characterized by numerous tandem (end-to-end) fusions. To study TRF1 and TRF2 telomere binding proteins in Muntiacus species, we isolated and characterized the TERF1 and -2 genes from Indian muntjac (Muntiacus muntjak v …
Chromosome evolution in the genus Muntiacus is characterized by numerous tandem (end-to-end) fusions. To study TRF1 and TRF2 telomere …
Compartmentalization of telomeres through DNA-scaffolded phase separation.
Jack A, Kim Y, Strom AR, Lee DSW, Williams B, Schaub JM, Kellogg EH, Finkelstein IJ, Ferro LS, Yildiz A, Brangwynne CP. Jack A, et al. Dev Cell. 2022 Jan 24;57(2):277-290.e9. doi: 10.1016/j.devcel.2021.12.017. Dev Cell. 2022. PMID: 35077681 Free PMC article.
Telomeres form unique nuclear compartments that prevent degradation and fusion of chromosome ends by recruiting shelterin proteins and regulating access of DNA damage repair factors. To understand how these dynamic components protect chromosome ends, we combine in vivo bio …
Telomeres form unique nuclear compartments that prevent degradation and fusion of chromosome ends by recruiting shelterin proteins an …
Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy.
Gramatges MM, Bertuch AA. Gramatges MM, et al. Transl Res. 2013 Dec;162(6):353-63. doi: 10.1016/j.trsl.2013.05.003. Epub 2013 Jun 1. Transl Res. 2013. PMID: 23732052 Free PMC article. Review.
As such, they prevent the natural ends of linear chromosomes from being subjected to DNA repair activities that would result in telomere fusion, degradation, or recombination. Both the DNA and protein components of the telomere are required for this essential function, bec …
As such, they prevent the natural ends of linear chromosomes from being subjected to DNA repair activities that would result in telomere …
Novel anticancer strategy aimed at targeting shelterin complexes by the induction of structural changes in telomeric DNA: hitting two birds with one stone.
Bidzinska J, Baginski M, Skladanowski A. Bidzinska J, et al. Curr Cancer Drug Targets. 2014;14(2):201-16. doi: 10.2174/1568009614666140120122535. Curr Cancer Drug Targets. 2014. PMID: 24443969 Review.
This telomeric DNA together with shelterins form a cap that protects the ends of chromosomes from being recognized as sites of DNA damage and from chromosomal fusions. Many very successful antitumor drugs used in the treatment of cancer patients bind to DNA, some of them w …
This telomeric DNA together with shelterins form a cap that protects the ends of chromosomes from being recognized as sites of DNA damage an …
Targeted deletion reveals an essential function for the telomere length regulator Trf1.
Karlseder J, Kachatrian L, Takai H, Mercer K, Hingorani S, Jacks T, de Lange T. Karlseder J, et al. Mol Cell Biol. 2003 Sep;23(18):6533-41. doi: 10.1128/MCB.23.18.6533-6541.2003. Mol Cell Biol. 2003. PMID: 12944479 Free PMC article.
Terf1(ex1Delta/ex1Delta) blastocysts had a severe growth defect of the inner cell mass that was accompanied by apoptosis. However, no evidence was found for telomere uncapping causing this cell death; chromosome spreads of Terf1(ex1Delta/ex1Delta) blastocysts did no …
Terf1(ex1Delta/ex1Delta) blastocysts had a severe growth defect of the inner cell mass that was accompanied by apoptosis. However, no …
[Advance of research on telomerase].
Hiyama K, Ishioka S, Hiyama E, Yamakido M. Hiyama K, et al. Gan To Kagaku Ryoho. 1998 Jul;25(8):1105-10. Gan To Kagaku Ryoho. 1998. PMID: 9679570 Review. Japanese.
Telomerase, a ribonucleoprotein enzyme which can compensate for the erosion of telomeric repeats each cell division, is considered to be associated with cellular immortality. The genes encoding the major components of human telomerase, TERC for telomerase RNA component, TE …
Telomerase, a ribonucleoprotein enzyme which can compensate for the erosion of telomeric repeats each cell division, is considered to be ass …
Genetic variation, nucleotide diversity, and linkage disequilibrium in seven telomere stability genes suggest that these genes may be under constraint.
Savage SA, Stewart BJ, Eckert A, Kiley M, Liao JS, Chanock SJ. Savage SA, et al. Hum Mutat. 2005 Oct;26(4):343-50. doi: 10.1002/humu.20226. Hum Mutat. 2005. PMID: 16110488
To maintain chromosomal integrity and to protect the ends of chromosomes against recognition as damaged DNA, end-to-end fusion, or recombination, a coordinated set of genes is required to stabilize the telomere. We surveyed common genetic variation in seven genes that are …
To maintain chromosomal integrity and to protect the ends of chromosomes against recognition as damaged DNA, end-to-end fusion, or re …
Genome-wide analysis of in vivo TRF1 binding to chromatin restricts its location exclusively to telomeric repeats.
Garrobo I, Marión RM, Domínguez O, Pisano DG, Blasco MA. Garrobo I, et al. Cell Cycle. 2014;13(23):3742-9. doi: 10.4161/15384101.2014.965044. Cell Cycle. 2014. PMID: 25483083 Free PMC article.
Telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes that protect them from degradation, end-to-end fusions, and fragility. In mammals, telomeres are composed of TTAGGG tandem repeats bound by a protein complex called shelterin, which has fundamenta …
Telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes that protect them from degradation, end-to-end fusions, …