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The following terms were not found in PubMed: YBX1P10, YBX1P10
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Clinical and genomic characterization of an ATRA-insensitive acute promyelocytic leukemia variant with a FNDC3B::RARB fusion.
Kirkham JK, Liu YC, Foy SG, Ma J, Gheorghe G, Furtado LV, Popescu MI, Klco JM, Karol SE, Blackburn PR. Kirkham JK, et al. Genes Chromosomes Cancer. 2023 Oct;62(10):617-623. doi: 10.1002/gcc.23180. Epub 2023 Jun 7. Genes Chromosomes Cancer. 2023. PMID: 37283355
We present a 13-year-old male diagnosed with variant APL with a novel FNDC3B::RARB in-frame fusion that showed no response to ATRA but responded well to conventional AML therapy. While FNDC3B has been identified as a rare RARA translocation partner in ATRA-sensitive …
We present a 13-year-old male diagnosed with variant APL with a novel FNDC3B::RARB in-frame fusion that showed no response to …
Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation.
Osumi T, Tsujimoto SI, Tamura M, Uchiyama M, Nakabayashi K, Okamura K, Yoshida M, Tomizawa D, Watanabe A, Takahashi H, Hori T, Yamamoto S, Hamamoto K, Migita M, Ogata-Kawata H, Uchiyama T, Kizawa H, Ueno-Yokohata H, Shirai R, Seki M, Ohki K, Takita J, Inukai T, Ogawa S, Kitamura T, Matsumoto K, Hata K, Kiyokawa N, Goyama S, Kato M. Osumi T, et al. Cancer Res. 2018 Aug 15;78(16):4452-4458. doi: 10.1158/0008-5472.CAN-18-0840. Epub 2018 Jun 19. Cancer Res. 2018. PMID: 29921692
Four of five RARA-negative APL cases had translocations involving retinoic acid receptor-beta (RARB) translocations, and TBL1XR1-RARB was identified as an in-frame fusion in three cases; one case had an RARB rearrangement detected by FISH, although the …
Four of five RARA-negative APL cases had translocations involving retinoic acid receptor-beta (RARB) translocations, and TBL1XR1-R …
Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes.
Chan EC, Lam SY, Fu KH, Kwong YL. Chan EC, et al. Cancer Genet Cytogenet. 2005 Oct 1;162(1):10-20. doi: 10.1016/j.cancergencyto.2005.03.008. Cancer Genet Cytogenet. 2005. PMID: 16157195
Results were correlated with aberrant methylation of the CDKN2A (alias p16(INK4A)), retinoic acid receptor beta (RARB), methylguanine-DNA methyltransferase (MGMT), and death-associated-protein (DAP) kinase genes in the tumors. ...These results showed that functional defici …
Results were correlated with aberrant methylation of the CDKN2A (alias p16(INK4A)), retinoic acid receptor beta (RARB), methylguanine …
Report of PRPF19 as a novel partner of RARG and the recurrence of interposition-type fusion in variant acute promyelocytic leukemia.
Wu H, Li H, Zhou X, Zhao Z, Cao P, Li L, Ma X, Yuan L, Wang F, Zhang Y, Chen J, Fang J, Liu M, Liu M, Chen X, Liu H. Wu H, et al. Hematol Oncol. 2023 Oct;41(4):784-788. doi: 10.1002/hon.3170. Epub 2023 May 2. Hematol Oncol. 2023. PMID: 37132198
Rarely, APLs are caused by atypical fusions involving RARA or, in fewer cases still, fusions involving other members of the retinoic acid receptors (RARB or RARG). ...The incomplete ligand-binding domain of RARG in the fusion protein may account for th …
Rarely, APLs are caused by atypical fusions involving RARA or, in fewer cases still, fusions involving other members of the re …
The genetics and clinical characteristics of children morphologically diagnosed as acute promyelocytic leukemia.
Zhao J, Liang JW, Xue HL, Shen SH, Chen J, Tang YJ, Yu LS, Liang HH, Gu LJ, Tang JY, Li BS. Zhao J, et al. Leukemia. 2019 Jun;33(6):1387-1399. doi: 10.1038/s41375-018-0338-z. Epub 2018 Dec 21. Leukemia. 2019. PMID: 30575821
Acute promyelocytic leukemia (APL) is characterized by t(15;17)(q22;q21), resulting in a PML-RARA fusion that is the master driver of APL. A few cases that cannot be identified with PML-RARA by using conventional methods (karyotype analysis, FISH, and RT-PCR) involve abnor …
Acute promyelocytic leukemia (APL) is characterized by t(15;17)(q22;q21), resulting in a PML-RARA fusion that is the master driver of …
Molecular Heterogeneity of Pediatric AML with Atypical Promyelocytes Accumulation in Children-A Single Center Experience.
Borkovskaia A, Bogacheva S, Konyukhova T, Dadakhanova E, Gaskova M, Soldatkina O, Dubrovina M, Popov A, Mikhailova E, Inushkina E, Kazanov M, Matveev E, Novichkova G, Maschan M, Maschan A, Olshanskaya Y, Zerkalenkova E. Borkovskaia A, et al. Genes (Basel). 2023 Mar 8;14(3):675. doi: 10.3390/genes14030675. Genes (Basel). 2023. PMID: 36980947 Free PMC article.
Of those, 255 cases were shown to carry a typical chromosomal translocation t(15;17)(q24;q21) with PML::RARA chimeric gene formation (94.1%). Other RARA-positive cases exhibited cryptic PML::RARA fusion without t(15;17)(q24;q21) (1.8%, n = 5) and variant t(5;17)(q35;q21) t …
Of those, 255 cases were shown to carry a typical chromosomal translocation t(15;17)(q24;q21) with PML::RARA chimeric gene formation (94.1%) …
DNA Methylation-Guided Prediction of Clinical Failure in High-Risk Prostate Cancer.
Litovkin K, Van Eynde A, Joniau S, Lerut E, Laenen A, Gevaert T, Gevaert O, Spahn M, Kneitz B, Gramme P, Helleputte T, Isebaert S, Haustermans K, Bollen M. Litovkin K, et al. PLoS One. 2015 Jun 18;10(6):e0130651. doi: 10.1371/journal.pone.0130651. eCollection 2015. PLoS One. 2015. PMID: 26086362 Free PMC article.
METHODS: A quantitative multiplex, methylation-specific PCR assay was developed to assess promoter methylation of the APC, CCND2, GSTP1, PTGS2 and RARB genes in formalin-fixed, paraffin-embedded tissue samples from 42 patients with benign prostatic hyperplasia and radical …
METHODS: A quantitative multiplex, methylation-specific PCR assay was developed to assess promoter methylation of the APC, CCND2, GSTP1, PTG …
A short report of novel RARG-HNRNPM fusion gene in resembling acute promyelocytic leukemia.
Song Y, Hou J, Wan L, Liu K, Zhou C, Wei S, Zhang G, Lin D, Li Y, Fang Q, Liu Y, Gong B, Gong X, Wang Y, Wei H, Wang J, Mi Y. Song Y, et al. Hematology. 2022 Dec;27(1):518-522. doi: 10.1080/16078454.2022.2066825. Hematology. 2022. PMID: 35544458
For years, RARA, RARB and RARG rearrangement were found in resembling APL continually. ...CASE PRESENTATION: We reported a 25-year-old female patient with a novel fusion gene RARG-HNRNPM (RARG chr12:53606869: -; HNRNPM chr19: 8527413: + based on GRCh37/hg19 Assembly …
For years, RARA, RARB and RARG rearrangement were found in resembling APL continually. ...CASE PRESENTATION: We reported a 25-year-ol …
Combination of DNA methylation biomarkers with multiparametric magnetic resonance and ultrasound imaging fusion biopsy to detect the local spread of prostate cancer.
Matulevičius A, Žukauskaitė K, Gineikaitė R, Dasevičius D, Trakymas M, Naruševičiūtė I, Ušinskienė J, Ulys A, Jankevičius F, Jarmalaitė S. Matulevičius A, et al. Prostate. 2023 Dec;83(16):1572-1583. doi: 10.1002/pros.24615. Epub 2023 Aug 23. Prostate. 2023. PMID: 37614027
Targeted biopsies were performed using the mpMRI/ultrasoundimage fusion system. RESULTS: Quantitative analysis revealed significantly higher DNA methylation levels of RARB, RASSF1, GSTP1 & APC genes in the index lesion compared with perifocal tissue samples 10 m …
Targeted biopsies were performed using the mpMRI/ultrasoundimage fusion system. RESULTS: Quantitative analysis revealed significantly …
Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia.
Shiba N, Yoshida K, Hara Y, Yamato G, Shiraishi Y, Matsuo H, Okuno Y, Chiba K, Tanaka H, Kaburagi T, Takeuchi M, Ohki K, Sanada M, Okubo J, Tomizawa D, Taki T, Shimada A, Sotomatsu M, Horibe K, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y. Shiba N, et al. Blood Adv. 2019 Oct 22;3(20):3157-3169. doi: 10.1182/bloodadvances.2019000404. Blood Adv. 2019. PMID: 31648321 Free PMC article.
We performed transcriptome analysis (RNA sequencing [RNA-seq]) in 139 of the 369 patients with de novo pediatric AML who were enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial and investigated correlations between genetic aberrations and clinical infor …
We performed transcriptome analysis (RNA sequencing [RNA-seq]) in 139 of the 369 patients with de novo pediatric AML who were enrolled in th …
16 results