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The following terms were not found in PubMed: Gm10120, Gm10120
Page 1
PML: Regulation and multifaceted function beyond tumor suppression.
Hsu KS, Kao HY. Hsu KS, et al. Cell Biosci. 2018 Jan 25;8:5. doi: 10.1186/s13578-018-0204-8. eCollection 2018. Cell Biosci. 2018. PMID: 29416846 Free PMC article. Review.
Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving rise to PML-RARalpha and RARalpha-PML fusi …
Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute pr …
PAX5 fusion genes in acute lymphoblastic leukemia: A literature review.
Fouad FM, Eid JI. Fouad FM, et al. Medicine (Baltimore). 2023 May 19;102(20):e33836. doi: 10.1097/MD.0000000000033836. Medicine (Baltimore). 2023. PMID: 37335685 Free PMC article. Review.
Additionally, ELN and PML genes have been found to fuse with PAX5, leading to adverse effects on B-cell differentiation. ELN-PAX5 interaction results in the decreased expression of LEF1, MB1, and BLNK, while PML-PAX5 is critical in the early stages of leukemia. PAX5 …
Additionally, ELN and PML genes have been found to fuse with PAX5, leading to adverse effects on B-cell differentiation. ELN-PAX5 int …
Regulation of NF-kappaB by PML and PML-RARalpha.
Ahmed A, Wan X, Mitxitorena I, Lindsay AJ, Paolo Pandolfi P, McCaffrey MW, Keeshan K, Chen YH, Carmody RJ. Ahmed A, et al. Sci Rep. 2017 Mar 20;7:44539. doi: 10.1038/srep44539. Sci Rep. 2017. PMID: 28317833 Free PMC article.
PML is a tumour suppressor and regulator of cell differentiation. ...This study establishes PML as an important regulator of NF-kappaB and demonstrates that PML-RARalpha dysregulates NF-kappaB....
PML is a tumour suppressor and regulator of cell differentiation. ...This study establishes PML as an important regulator of N …
Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARalpha and PLZF/RARalpha with interfering peptides.
Beez S, Demmer P, Puccetti E. Beez S, et al. PLoS One. 2012;7(11):e48636. doi: 10.1371/journal.pone.0048636. Epub 2012 Nov 9. PLoS One. 2012. PMID: 23152790 Free PMC article.
Both fusion proteins lead to the formation of a high-molecular-weight complex. High-molecular-weight complexes are caused by the "coiled-coil" domain of PML or the BTB/POZ domain of PLZF. PML/RARalpha without the "coiled-coil" fails to block differentiation a …
Both fusion proteins lead to the formation of a high-molecular-weight complex. High-molecular-weight complexes are caused by the "coi …
Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure.
de Thé H, Pandolfi PP, Chen Z. de Thé H, et al. Cancer Cell. 2017 Nov 13;32(5):552-560. doi: 10.1016/j.ccell.2017.10.002. Cancer Cell. 2017. PMID: 29136503 Free article. Review.
Restoration of PML nuclear bodies upon RA- and/or arsenic-initiated PML/RARA degradation is essential, while RA-triggered transcriptional activation is dispensable for APL eradication. Mutations of the arsenic-binding site of PML/RARA, but also PML, ha …
Restoration of PML nuclear bodies upon RA- and/or arsenic-initiated PML/RARA degradation is essential, while RA-triggered tran …
Role of PML and the PML-nuclear body in the control of programmed cell death.
Bernardi R, Pandolfi PP. Bernardi R, et al. Oncogene. 2003 Dec 8;22(56):9048-57. doi: 10.1038/sj.onc.1207106. Oncogene. 2003. PMID: 14663483 Review.
PML epitomizes a multiprotein nuclear structure, the PML-nuclear body (PML-NB), whose proper formation and function depends on PML. Studies in knockout (KO) mice and cells unraveled an essential pleiotropic role for PML in multiple p53-de …
PML epitomizes a multiprotein nuclear structure, the PML-nuclear body (PML-NB), whose proper formation and function dep …
PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus.
Burroughs AF, Eluhu S, Whalen D, Goodwin JS, Sakwe AM, Arinze IJ. Burroughs AF, et al. Cell Physiol Biochem. 2018;47(2):800-816. doi: 10.1159/000490033. Epub 2018 May 22. Cell Physiol Biochem. 2018. PMID: 29807365 Free PMC article.
By inhibiting nuclear export using Leptomycin B, we provide direct evidence that degradation of Nrf2 also occurs in the nucleus and involves PML-NBs (Promyelocytic Leukemia-nuclear bodies). We further demonstrate that co-expression of Dendra2-Nrf2 and Crimson-PML-I …
By inhibiting nuclear export using Leptomycin B, we provide direct evidence that degradation of Nrf2 also occurs in the nucleus and involves …
PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model.
Kelly LM, Kutok JL, Williams IR, Boulton CL, Amaral SM, Curley DP, Ley TJ, Gilliland DG. Kelly LM, et al. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8283-8. doi: 10.1073/pnas.122233699. Proc Natl Acad Sci U S A. 2002. PMID: 12060771 Free PMC article.
The most common fusion partner is promyelocytic leukemia protein (PML), which is fused to RARalpha in the balanced reciprocal chromosomal translocation, t(15;17)(q22:q11). ...Retroviral transduction of FLT3-ITD into bone marrow cells obtained from PML/RARalph …
The most common fusion partner is promyelocytic leukemia protein (PML), which is fused to RARalpha in the balanced reciprocal …
Autophagy and Ubiquitin-Mediated Proteolytic Degradation of PML/Raralpha Fusion Protein in Matrine-Induced Differentiation Sensitivity Recovery of ATRA-Resistant APL (NB4-LR1) Cells: in Vitro and in Vivo Studies.
Wu D, Shao K, Zhou Q, Sun J, Wang Z, Yan F, Liu T, Wu X, Ye B, Huang H, Zhou Y. Wu D, et al. Cell Physiol Biochem. 2018;48(6):2286-2301. doi: 10.1159/000492646. Epub 2018 Aug 16. Cell Physiol Biochem. 2018. PMID: 30114705 Free article.
RESULTS: MAT improved the sensitivity of NB4-LR1cells to ATRA treatment, which was consistent with the expression of PML-RARalpha fusion protein. MAT promoted the ubiquitylation level in NB4-LR1. ...The expression of LC3II increased significantly in the MAT and ATRA …
RESULTS: MAT improved the sensitivity of NB4-LR1cells to ATRA treatment, which was consistent with the expression of PML-RARalpha …
Therapy-induced PML/RARA proteolysis and acute promyelocytic leukemia cure.
Nasr R, Lallemand-Breitenbach V, Zhu J, Guillemin MC, de Thé H. Nasr R, et al. Clin Cancer Res. 2009 Oct 15;15(20):6321-6. doi: 10.1158/1078-0432.CCR-09-0209. Epub 2009 Oct 6. Clin Cancer Res. 2009. PMID: 19808868 Review.
Acute promyelocytic leukemia (APL) is characterized by a specific t(15;17) chromosomal translocation that yields the PML/RARA fusion gene. Clinically, besides chemotherapy, two drugs induce clinical remissions: retinoic acid (RA) and arsenic trioxide (As). ...RA tar …
Acute promyelocytic leukemia (APL) is characterized by a specific t(15;17) chromosomal translocation that yields the PML/RARA fusi …
282 results